2018
DOI: 10.31234/osf.io/ws9dr
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The role of the opioid system in decision making and cognitive control: A review

Abstract: The opioid system plays a key role in the regulation of affective processing including pain, pleasure, and reward. However, there is also increasing evidence that this system plays a broader role and can modulate cognitive function. In particular, increasing evidence suggests that the mu-opioid system influences how we choose between actions of different values and how we control our behavior in the face of distracting information. The present paper reviews the available evidence from studies that have used ph… Show more

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Cited by 14 publications
(15 citation statements)
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References 140 publications
(178 reference statements)
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“…These results based on T1-weighted MR imaging or [18F]-FDG-PET are however unspecific with respect to the underlying neurobiology, whereas the present data point towards altered opioidergic neurotransmission as a potential molecular mechanism. Because ACC and insulae are involved in both affective and executive functions impaired in MDD [ 54 , 55 ], this also fits with the data showing that opioidergic system modulates both executive [ 2 ] and affective functions [ 1 ]. Age is strong predictor of MOR availability [ 35 , 56 ] and this effect—negative associations in midbrain/amygdala and positive associations in frontal and temporal cortex—was also observed in this sample (data not shown).…”
Section: Discussionsupporting
confidence: 80%
“…These results based on T1-weighted MR imaging or [18F]-FDG-PET are however unspecific with respect to the underlying neurobiology, whereas the present data point towards altered opioidergic neurotransmission as a potential molecular mechanism. Because ACC and insulae are involved in both affective and executive functions impaired in MDD [ 54 , 55 ], this also fits with the data showing that opioidergic system modulates both executive [ 2 ] and affective functions [ 1 ]. Age is strong predictor of MOR availability [ 35 , 56 ] and this effect—negative associations in midbrain/amygdala and positive associations in frontal and temporal cortex—was also observed in this sample (data not shown).…”
Section: Discussionsupporting
confidence: 80%
“…The acute use of these substances (single agent or combinations) may be short‐lived and therefore require repeat assessments. There is growing evidence that substance use disorder or withdrawal can also alter decision‐making capacity …”
Section: Special Populationsmentioning
confidence: 99%
“…However, as found in numerous studies relating to the so-called 'rationality debate' (see, e.g., [28], [44]; see [26] for a brief outline), choices and decisions in real life are often adopted in substantial discordance with norms of rationality. There exists a growing body of literature on the role of the value-network (commonly referred to as the reward system) in decision-making under various circumstances ( [38], [24], [45], [2]). The value-system plays the role of the arbiter in conflict resolution, which is of central relevance indecisionmaking.…”
Section: Free Willmentioning
confidence: 99%