The role of the orphan nuclear receptor COUP-TFII in tumorigenesis

Xu, Mafei; Qin, Jun; Tsai, Sophia Y.; Tsai, Ming‐Jer

doi:10.1038/aps.2014.86

Cited by 37 publications

(30 citation statements)

References 33 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CENPF (centromere protein F) encodes a protein that associates with the centromere-kinetochore complex(28) and COUP-TFII an orphan nuclear receptor (29). The localization of CENPF points toward its role in chromosome segregation during mitosis.…”

Section: Synergy Between Foxm1 and Cenpf To Stimulate Prostate Camentioning

confidence: 99%

FOXM1 in Cancer: Interactions and Vulnerabilities

2017

View full text Add to dashboard Cite

FOXM1 is a transcription factor of the Forkhead family that is required for cell proliferation of normal cells. However, FOXM1 is repeatedly overexpressed in a variety of human cancers and it has been implicated in all major hallmarks of cancer delineated by Hanahan and Weinberg. It has been postulated that the oncogenic potential of FOXM1 is determined by its capacity to trans-activate target genes that are implicated in different phases of cancer development. However, FOXM1 may also play an oncogenic role by interacting with other proteins such as beta-catenin or SMAD3 to induce oncogeneic WNT and TGF-β signaling pathways, respectively. In this review, I will discuss the protein-protein interactions of FOXM1 that are critical for cancer development and may represent novel targets for anticancer drugs.

show abstract

Section: Synergy Between Foxm1 and Cenpf To Stimulate Prostate Camentioning

confidence: 99%

FOXM1 in Cancer: Interactions and Vulnerabilities

2017

View full text Add to dashboard Cite

show abstract

“…Extensive studies show that COUP-TFII plays a key role in certain vital processes including development and organogenesis, vasculature and lympangiogenesis, reproduction, and energy metabolism. Aberrant expression of COUP-TFII is observed in some cancers, including pancreatic, breast, colon, ovarian and prostate [39]. Studies of transgenic knockout and cancer mouse models show that ablation of COUP-TFII can impair tumor angiogenesis and lymph node metastasis, implicating the involvement of COUP-TFII in regulation of tumor growth and metastasis [40][41][42].…”

Section: Coup-tfsmentioning

confidence: 99%

The emerging roles of orphan nuclear receptors in prostate cancer

Cheung

Wang

et al. 2016

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

View full text Add to dashboard Cite

Orphan nuclear receptors are members of the nuclear receptor (NR) superfamily and are so named because their endogenous physiological ligands are either unknown or may not exist. Because of their important regulatory roles in many key physiological processes, dysregulation of signalings controlled by these receptors is associated with many diseases including cancer. Over years, studies of orphan NRs have become an area of great interest because their specific physiological and pathological roles have not been well-defined, and some of them are promising drug targets for diseases. The recently identified synthetic small molecule ligands, acting as agonists or antagonists, to these orphan NRs not only help to understand better their functional roles but also highlight that the signalings mediated by these ligand-independent NRs in diseases could be therapeutically intervened. This review is a summary of the recent advances in elucidating the emerging functional roles of orphan NRs in cancers, especially prostate cancer. In particular, some orphan NRs, RORγ, TR2, TR4, COUP-IFII, ERRα, DAX1 and SHP, exhibit crosstalk or interference with androgen receptor (AR) signaling in either normal or malignant prostatic cells, highlighting their involvement in prostate cancer progression as androgen and AR signaling pathway play critical roles in this process. We also propose that a better understanding of the mechanism of actions of these orphan NRs in prostate gland or prostate cancer could help to evaluate their potential value as therapeutic targets for prostate cancer.

show abstract

“…The second review article by Ikeda and coworkers covers the roles of estrogen-responsive genes in breast cancer [2] . Beside androgen receptor and estrogen receptor, the two of classical steroid hormone receptors in cancers, orphan nuclear receptors COUPTFs also known to play important role in tumorigenesis, and they are respectively reviewed by Xu and coworkers [3] . In addition, the roles of bile acid receptor FXR in liver cancer will be reviewed by Huang and coworkers [4] .…”

mentioning

confidence: 99%

Family reunion of nuclear hormone receptors: structures, diseases, and drug discovery

2015

Acta Pharmacol Sin

View full text Add to dashboard Cite

EditorialHormones comprise one of the most effective classes of messengers that transmit cell to cell communication in eukaryotic systems. Cells receive messages of hormones through protein receptors, and then translate the hormone signals into concrete action of physiological responses. Homeostasis of hormone systems is essential for human health, and aberrant regulation of hormone signaling has been associated with many diseases, including cancer, diabetes, and inflammation diseases. As such, targeting hormone signaling pathways has become a major venue of pharmacological intervention of many health abnormalities. There are two major classes of hormone receptors: G-protein coupled receptors and nuclear hormone receptors, both of which consist of the top two classes of the most successful drug targets. Two years ago, we published a special issue on structures, biology and drug discovery of G-protein coupled receptors, which has been well received by drug discovery research communities. This year marked the 30th anniversary of the cloning of the first member of the nuclear receptor family and 25th year of the discovery of orphan nuclear receptors, for which no cognate ligands were known at the time of their cloning. Since then we have witnessed a tremendous expansion of our knowledge of this family of receptors. In this special issue, we collected eleven exciting review articles, highlighting our current understanding of structure, function, disease relevance, and drug discovery of nuclear receptors.Hormones androgen and estrogen have long been known to play key roles in development, growth, and homeostasis of reproductive systems and their dysregulation is the major cause of prostate cancer and breast cancer. The first article by Tan and coworkers will provide comprehensive review on structures, diseases relevance and drug discovery of androgen receptor, the oncogenic driver of prostate cancer [1] . The second review article by Ikeda and coworkers covers the roles of estrogen-responsive genes in breast cancer [2] . Beside androgen receptor and estrogen receptor, the two of classical steroid hormone receptors in cancers, orphan nuclear receptors COUPTFs also known to play important role in tumorigenesis, and they are respectively reviewed by Xu and coworkers [3] . In addition, the roles of bile acid receptor FXR in liver cancer will be reviewed by Huang and coworkers [4] . Nuclear hormone receptors are also well known for their central roles in metabolic regulation. Classic examples are peroxisome proliferator activated receptors (PPARs) and receptors for glucocorticoids and thyroid hormone, for which roles have been well reviewed in the literatures. In this special issue, we will focus on the emerging roles of orphan nuclear receptors in metabolism. Jiao and coworkers review the regulatory role of FXR in homeostasis of hepatic triglyceride [5] . Audet-wash and Giguère review the roles of estrogen-related receptor α and γ in metabolic control and related diseases [6] . Yan and Xie review the role of constitutive...

show abstract

The role of the orphan nuclear receptor COUP-TFII in tumorigenesis

Cited by 37 publications

References 33 publications

FOXM1 in Cancer: Interactions and Vulnerabilities

FOXM1 in Cancer: Interactions and Vulnerabilities

The emerging roles of orphan nuclear receptors in prostate cancer

Family reunion of nuclear hormone receptors: structures, diseases, and drug discovery

Contact Info

Product

Resources

About