The role of the orphan G protein-coupled receptor 37 (GPR37) in multiple myeloma cells

Huang, Xing‐Huai; Wang, Yuchan; Nan, Xuemei; He, Song; Xu, Xiaohong; Zhu, Xinghua; Tang, Jie; Yang, Xiaojing; Yao, Li; Wang, Xinxiu; Cheng, Chun

doi:10.1016/j.leukres.2013.11.007

Cited by 29 publications

(20 citation statements)

References 42 publications

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“…Consistent with the exiting studies, the sensitivity of adherent RPMI-8226 and U266 cells to doxorubicin and mitoxantrone is lower that of cells in suspension ( Fig. 5A and B) (2,12,26). The drug resistance was further increased in both RPMI-8226 and U266 cells after interference with Homer1b/c siRNA ( Fig.…”

Section: The Expression Of Homer1b/c Associated With Cell Adhesion Insupporting

confidence: 82%

Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells

Tang¹,

Zhou²,

Wang³

et al. 2015

Oncology Reports

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Previous studies have demonstrated that Homer1b/c plays an important pro-apoptotic role through classical mitochondrial apoptotic pathway. The present study was undertaken to determine the expression and functional significance of Homer1b/c in multiple myeloma (MM). We found that Homer1b/c was lowly expressed in MM cell apoptotic model induced by doxorubicin. The positive role of Homer1b/c in cell apoptosis was further confirmed by knocking down Homer1b/c. Further study confirmed that Homer1b/c was able to affect the CAM-DR via pro-apoptotic activity regulating the ability of cell adhesion. Collectively, these data indicate that Homer1b/c may represent a good candidate for pursuing clinical trial in MM.

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Section: The Expression Of Homer1b/c Associated With Cell Adhesion Insupporting

confidence: 82%

Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells

Tang¹,

Zhou²,

Wang³

et al. 2015

Oncology Reports

Self Cite

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“…The data in the present study were analyzed using SPSS v. 19.0 software (IBM Corp., Armonk, NY, USA). Data are presented as the mean ± standard error of the mean.…”

Section: Discussionmentioning

confidence: 99%

“…Western blot analysis. Western blot analysis was carried out as previously described (19). Tissue extracts were made with a detergent lysis buffer [50 mM Tris (pH 7.4); 150 mM NaCl; 1% NP-40; 0.5% sodium deoxycholate; 0.1% SDS; and the protease inhibitor, 1 mmol/l phenylmethanesulfonyl fluoride].…”

Section: Methodsmentioning

confidence: 99%

Silencing of LIMD1 promotes proliferation and reverses cell adhesion‑mediated drug resistance in non‑Hodgkin's lymphoma

et al. 2019

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LIM domains-containing protein 1 (LIMD1) is a tumor suppressor protein downregulated in numerous solid malignancies. However, the functional role of LIMD1 in non-Hodgkin's lymphoma (NHL) remains unclear. In the present study, it was demonstrated that LIMD1 is associated with the proliferation of NHL and cell adhesion mediated-drug resistance (CAM-DR). It was indicated by western blot analysis that LIMD1expression is lower in progressive lymphoma compared with indolent lymphoma. Furthermore, it was indicated that the role of LIMD1 in cell viability and proliferation remains unclear. Finally, the present study demonstrated that LIMD1 serves an important role in CAM-DR by regulating cell cycle progression. Silencing of LIMD1 may reverse CAM-DR in NHL. Therefore, the findings of the present study suggested that LIMD1 may be a potential therapeutic target for patients with NHL.

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“…For the other receptors of this subgroup, information relative to their implication in cancer is rare (one report for GPR37 [165]) or lacking.…”

Section: Discussionmentioning

confidence: 99%

Comparative Expression Study of the Endo–G Protein Coupled Receptor (GPCR) Repertoire in Human Glioblastoma Cancer Stem-like Cells, U87-MG Cells and Non Malignant Cells of Neural Origin Unveils New Potential Therapeutic Targets

et al. 2014

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Glioblastomas (GBMs) are highly aggressive, invasive brain tumors with bad prognosis and unmet medical need. These tumors are heterogeneous being constituted by a variety of cells in different states of differentiation. Among these, cells endowed with stem properties, tumor initiating/propagating properties and particularly resistant to chemo- and radiotherapies are designed as the real culprits for tumor maintenance and relapse after treatment. These cells, termed cancer stem-like cells, have been designed as prominent targets for new and more efficient cancer therapies. G-protein coupled receptors (GPCRs), a family of membrane receptors, play a prominent role in cell signaling, cell communication and crosstalk with the microenvironment. Their role in cancer has been highlighted but remains largely unexplored. Here, we report a descriptive study of the differential expression of the endo-GPCR repertoire in human glioblastoma cancer stem-like cells (GSCs), U-87 MG cells, human astrocytes and fetal neural stem cells (f-NSCs). The endo-GPCR transcriptome has been studied using Taqman Low Density Arrays. Of the 356 GPCRs investigated, 138 were retained for comparative studies between the different cell types. At the transcriptomic level, eight GPCRs were specifically expressed/overexpressed in GSCs. Seventeen GPCRs appeared specifically expressed in cells with stem properties (GSCs and f-NSCs). Results of GPCR expression at the protein level using mass spectrometry and proteomic analysis are also presented. The comparative GPCR expression study presented here gives clues for new pathways specifically used by GSCs and unveils novel potential therapeutic targets.

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The role of the orphan G protein-coupled receptor 37 (GPR37) in multiple myeloma cells

Cited by 29 publications

References 42 publications

Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells

Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells

Silencing of LIMD1 promotes proliferation and reverses cell adhesion‑mediated drug resistance in non‑Hodgkin's lymphoma

Comparative Expression Study of the Endo–G Protein Coupled Receptor (GPCR) Repertoire in Human Glioblastoma Cancer Stem-like Cells, U87-MG Cells and Non Malignant Cells of Neural Origin Unveils New Potential Therapeutic Targets

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