2001
DOI: 10.1038/eye.2001.141
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The role of the retinal pigment epithelium: Topographical variation and ageing changes

Abstract: The role of the retinal pi g ment epithelium:topo g raphical variation and a g ein g chan g es AbstractThe retinal pigment epithelium (RPE) is a single layer of post-mitotic cells, which functions both as a selective barrier to and a vegetative regulator of the overlying photoreceptor layer, thereby playing a key role

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Cited by 407 publications
(268 citation statements)
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“…1 and 2a). [1][2][3][4] RPE is a hexagonally packed, tight-junction connected, single sheet of post-mitotic cells containing pigment granules. Interactions between both the RPE and the PR are essential for visual function.…”
Section: Retinal Pigment Epitheliummentioning
confidence: 99%
“…1 and 2a). [1][2][3][4] RPE is a hexagonally packed, tight-junction connected, single sheet of post-mitotic cells containing pigment granules. Interactions between both the RPE and the PR are essential for visual function.…”
Section: Retinal Pigment Epitheliummentioning
confidence: 99%
“…4,5 Increased accumulation of lipofuscin in the RPE has been observed in various degenerative disorders. [6][7][8][9] Lipofuscin distribution can be visualized by fundus autofluorescence (FAF; excitation 488 nm, emission 4500 nm). 10 Characteristic patterns of FAF abnormalities have been reported in RP, and their association with retinal function has been demonstrated.…”
Section: Introductionmentioning
confidence: 99%
“…[11][12][13][14] In contrast, melanin is the major protective agent in the RPE cells sheltering the RPE from exposure to light scattering, radiation, oxidative stress, and light damage. 9,15,16 Melanin granules accumulate in the apical part of the RPE cells undergoing a moderate decrease in numbers with age. 17 Melanin distribution in the RPE can be visualized using near-infrared autofluorescence (NIA, excitation 787 nm, emission 4800 nm).…”
Section: Introductionmentioning
confidence: 99%
“…These appear to occur in response to deposition of abnormal material within Bruch's membrane, which accumulate during the early course of ARM. [8][9][10][11][12][13] Current treatment options for ARM are limited, but they can be effective at slowing progression of the disease if applied early. [14][15][16][17][18] It is important to investigate the early stage of ARM as defined by drusen and RPE abnormalities, 19 where there is hardly any subjective vision function loss to better understand the pathogenesis and the mechanisms underlying ARM.…”
Section: Introductionmentioning
confidence: 99%