2007
DOI: 10.21836/pem20070101
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The role of the specific, profilaggrin-containing keratohyalin granules in the developing epidermis of the fetal horse hoof

Abstract: SummaryThe adult equine hoof is subdivided into distinct segments with various keratinization modes. In the periople and bulbs of the heel, the epidermis forms a Stratum granulosum with basophilic keratohyalin granules during soft keratinization, whereas in the coronet, wall proper, sole, and frog, the epidermis undergoes hard keratinization by keratinizing and cornifying without forming keratohyalin granules. The present study tests the hypothesis that the presence of specific (profilaggrin-containing) kerato… Show more

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Cited by 6 publications
(9 citation statements)
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“…2008). The latter is not surprising, as Bragulla (1996) and Bragulla & Homberger (2007) have shown for the equine hoof that a Stratum granulosum with profilaggrin containing keratohyalingranula is absent in hard‐cornifying stratified epithelia. The expression of caspase‐14 may be activated by a transcription factor of the family of activator protein 1 (AP‐1).…”
Section: Keratins and The Process Of Keratinizationmentioning
confidence: 77%
“…2008). The latter is not surprising, as Bragulla (1996) and Bragulla & Homberger (2007) have shown for the equine hoof that a Stratum granulosum with profilaggrin containing keratohyalingranula is absent in hard‐cornifying stratified epithelia. The expression of caspase‐14 may be activated by a transcription factor of the family of activator protein 1 (AP‐1).…”
Section: Keratins and The Process Of Keratinizationmentioning
confidence: 77%
“…It is not disputed that nail or hoof is formed by the proliferation of epidermal cells, rather that the resulting structures differ enough from skin at the histological and biochemical levels to require specific descriptors . In particular, keratin isoform expression may differ between the two tissues, and normal adult epidermal lamellae, in contrast to skin epidermis, do not demonstrate a granular cell layer, although a granular cell layer is present during fetal hoof development . We have chosen to use the term ‘epidermal lamella’ because of the following factors: (i) it recognizes the developmental origin of the tissue; (ii) it recognizes the shared histological and biochemical features of skin and lamellar stratified, cornifying epithelia; (iii) it does not equate the tissue with skin epidermis, because ‘epidermal’ is used as an adjective to describe a specific anatomical structure, the lamella of the inner hoof capsule; (iv) it facilitates the distinction of epidermal and dermal lamellae and the importance of dermo‐epidermal integrity in the maintenance of the suspensory apparatus of the distal phalanx; and (v) it is consistent with the majority of the laminitis literature.…”
Section: Introductionmentioning
confidence: 99%
“…Traditionally, the epidermis of cornified end organs was assumed to contain hard keratin in contrast to the epidermis of the skin, which was assumed to contain soft keratin (see Homberger & Brush, 1986; Homberger, 2001). Currently, however, our understanding of the processes involved in the keratinization and cornification of digital end organs has become much more differentiated (see Bragulla & Homberger, 2007, 2009). Cornified digital end organs comprise hard‐cornified horn segments as well as soft‐cornified ones, at least in mammals (Table 2) (Bragulla & Homberger, 2007, 2009).…”
Section: Observationsmentioning
confidence: 99%
“…Currently, however, our understanding of the processes involved in the keratinization and cornification of digital end organs has become much more differentiated (see Bragulla & Homberger, 2007, 2009). Cornified digital end organs comprise hard‐cornified horn segments as well as soft‐cornified ones, at least in mammals (Table 2) (Bragulla & Homberger, 2007, 2009). In mammals, the hard‐cornified epidermis contains so‐called hard keratin proteins, whereas the soft‐cornified epidermis contains so‐called soft keratin proteins.…”
Section: Observationsmentioning
confidence: 99%
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