The role of the spleen and the hepatic artery in the regulation of liver blood flow

Grayson, J.; Mendel, David

doi:10.1113/jphysiol.1957.sp005743

Cited by 21 publications

(8 citation statements)

References 15 publications

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“…Liver blood flow was then recorded for a further 30 min. Three experiments were performed in animals with blood pressures stabilized at 80 mm Hg, the pressure at which, according to previous work (Grayson & Mendel, 1957), hepatic arterial contribution to liver blood flow is maximal. Fig.…”

Section: The Effect Of Portal Vein Ligation On Liver Blood Flowmentioning

confidence: 99%

“…Resistance to portal flow before hepatic arterial ligation was determined as follows. Since blood flow in the liver fell to 61 % of resting values after ligation of the hepatic artery, it might be concluded that this represents the percentage contribution to liver blood of the portal vein (Grayson & Mendel, 1957). Taking this percentage as representative of the contribution in the J. GRAYSON AND D. MENDEL intact liver, the portal contributions to the recorded Sk values were calculated and resistance to portal flow calculated as above.…”

Section: Intrahepatic Flow Relationsmentioning

confidence: 99%

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Observations on the intrahepatic flow interactions of the hepatic artery and portal vein

Grayson¹,

Mendel²

1957

The Journal of Physiology

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Section: The Effect Of Portal Vein Ligation On Liver Blood Flowmentioning

confidence: 99%

Section: Intrahepatic Flow Relationsmentioning

confidence: 99%

Observations on the intrahepatic flow interactions of the hepatic artery and portal vein

Grayson¹,

Mendel²

1957

The Journal of Physiology

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“…Grayson and Mendel (6) and Fischer (7) have suggested that the artery may provide a means of regulating the total blood flow as well as the oxygenation. Rappaport (8) believed that the pulsatile nature of the arterial From the Departments of Physics and Physiology, University of the West Indies, Jamaica.…”

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confidence: 99%

Investigation of the Hepatic Arterial "Space" under Various Conditions of Flow in the Isolated Perfused Dog Liver

Field

Andrews

1968

Circulation Research

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A radioactive isotope dilution technique, in which two radioactive tracers were used simultaneously, was employed to investigate the nature of the hepatic arterial vascular bed or arterial vascular "space" in 22 isolated perfused canine livers. The technique continuously monitored the blood leaving the liver for radioactivity so that no assumptions had to be made regarding the representative nature of samples. The concept of an arterial vascular space was defined in terms of the mean circulation time of labeled red cells through the perfused organ, and the variation of this parameter with variations in arterial flow was considered; agreement with other published work was shown. The experiments on the size of the arterial vascular space showed a linear relationship between the arterial fraction of the blood occupying the total hepatic vascular bed and the arterial fraction of the total hepatic blood flow. The evidence from these experiments supported the idea that the artery and the portal vein share a large proportion of the total hepatic vascular bed.ADDITIONAL KEY WORDS isotope dilution arterial vascular "space" mean circulation time hepatic vascular bed portal vein

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“…Two different methods using this principle are available. The principle of internal calorimetry (Grayson, 1952) uses a cyclic current for heating of the thermocouple in order to avoid external local heat production (Grayson & Mendel, 1954), while a constant current is supplied to the thermocouple utilizing the method of Hensel, Ruef & Golenhofen (1954). However, this measurement is semiquantitative and only changes in total liver blood flow can be measured, but the advantage is that measurements can be made over a longer period of time.…”

Section: B) Heat Exchange Methodsmentioning

confidence: 99%

Methods of the assessment of the effect of drugs on liver blood flow in man.

Ohnhaus¹

1979

Brit J Clinical Pharma

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The role of the spleen and the hepatic artery in the regulation of liver blood flow

Cited by 21 publications

References 15 publications

Observations on the intrahepatic flow interactions of the hepatic artery and portal vein

Observations on the intrahepatic flow interactions of the hepatic artery and portal vein

Investigation of the Hepatic Arterial "Space" under Various Conditions of Flow in the Isolated Perfused Dog Liver

Methods of the assessment of the effect of drugs on liver blood flow in man.

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