The objective of this research is to study the level of startups’ creative innovations and business performance under the national programme Thailand 4.0. The research is using mixed methods, and the population of this study consists of entrepreneurs and executives, including those who are directly participating in the development of creative innovations in Thailand. The research findings indicate that there are three main variables of creative innovation, namely: (1) Learning Innovation, (2) Communication Innovation, and (3) Operational Support Innovation. The Communication Innovation was ranked No. 1 as it has the highest mean (x̄ = 4.29, S.D. = 0.51) while the 2nd rank was assigned to Learning Innovation with the highest mean (x̄ = 4.25, S.D. = 0.51), the 3rd rank got Operational Support Innovation with the highest mean (x̄ = 4.22, S.D. = 0.55), all variables were found to be statistically significant.