The role of the sugar receptor IR60b for <i>Drosophila melanogaster</i>: A hypothesis

Szyszka, Paul; Galizia, C. Giovanni

doi:10.7287/peerj.preprints.3511

Cited by 2 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the flies used in this study was fed with diet supplemented with sucrose, it is therefore paramount to assay for the activities of carbohydrate hydrolyzing enzymes. Report has shown that amylase and sucrase are the major carbohydrate hydrolyzing enzymes found in fruit fly (Haloi, Hasan, & Boro, 2014; Szyszka & Galizia, 2018). α‐amylase is involved in the hydrolysis of starch and other polysaccharides to disaccharides and α‐glucosidase is responsible for the breakdown of disaccharides such as sucrose to absorbable monosaccharides in living organisms.…”

Section: Resultsmentioning

confidence: 99%

Modulatory effects of moringa (Moringa oleiferaL.) leaves infested with African mistletoe (Tapinanthus bangwensisL.) on the antioxidant, antidiabetic, and neurochemical indices in high sucrose diet‐induced diabetic‐like phenotype in fruit flies (Drosophila melanogasterM.)

2020

View full text Add to dashboard Cite

Mistletoes (Tapinanthus bangwensis L.) are hemi-parasites which are attached to the branches and stems of host plants via specialized absorbing organ called haustorium; this translocates water and mineral nutrients from the host plant to the parasite. They always bear evergreen leaves that photosynthesize and they belong to the Loranthaceae family (Edagbo et al., 2012; Milius, 2000). They grow on a wide range of host trees of medicinal and economic importance such as moringa, cashew, orange, mango, grape, kola nut, cocoa, rubber, and others; different host species may supply a parasite with different resources and vice-versa. Mistletoe leaves from different host plants are traditionally used in the treatment of a number of ailments like nervousness, sterility, rheumatism, psychosis, diabetes, cancer, epilepsy and hypertension (Adodo, 2004; Jadhav et al., 2010). Several reports have suggested possible fundamental changes in the metabolic profile and biological activities of host plant (Cuevas-Reyes,

show abstract

Section: Resultsmentioning

confidence: 99%

Modulatory effects of moringa (Moringa oleiferaL.) leaves infested with African mistletoe (Tapinanthus bangwensisL.) on the antioxidant, antidiabetic, and neurochemical indices in high sucrose diet‐induced diabetic‐like phenotype in fruit flies (Drosophila melanogasterM.)

2020

View full text Add to dashboard Cite

show abstract

“…For example, IR52c and IR52d are expressed in sexually-dimorphic populations of leg neurons and implicated in male courtship behaviours 26 , although their ligands are unknown. Reporters for IR60b, IR94f and IR94h are co-expressed in pharyngeal GSNs that respond to sucrose, which may limit overfeeding 29 or monitor the state of externally digested food 30 . IR62a is essential for behavioural avoidance of high Ca 2+ concentrations, but the precise neuronal expression of this receptor is unclear 31 .…”

Section: Introductionmentioning

confidence: 99%

An expression atlas of chemosensory ionotropic glutamate receptors identifies a molecular basis of carbonation detection

Sánchez-Alcañiz

Silbering

Croset

et al. 2018

Preprint

View full text Add to dashboard Cite

Taste perception is thought to involve the encoding of appetitive and aversive chemical cues in food through a limited number of sensory pathways. Through expression analysis of the complete repertoire of Drosophila Ionotropic Receptors (IRs), a sensory subfamily of ionotropic glutamate receptors, we reveal that the majority of IRs is expressed in diverse peripheral neuron populations across gustatory organs in both larvae and adults, implying numerous roles in taste-evoked behaviours. We characterise Ir56d, which labels two anatomically-distinct classes of neurons in the proboscis: one represents a subset of sugar-and fatty acid-sensing neurons, while the other responds to carbonated solutions and fatty acids. Mutational analysis shows that IR56d, together with the broadly-expressed co-receptors IR25a and IR76b, is essential for physiological activation by carbonation and fatty acids, but not sucrose. We further demonstrate that carbonation is behaviourally attractive to flies (in an IR56d-dependent manner), but in a distinct way to other appetitive stimuli. Our work provides a valuable toolkit for investigating the taste functions of IRs, defines a molecular basis of carbonation sensing, and illustrates how the gustatory system uses combinatorial expression of sensory receptors in distinct neuron types to coordinate behaviour.Classic models of gustatory perception in mammals highlight the existence of a small number of taste classes signalling nutritive content (e.g., sugars and amino acids) or toxicity (e.g., bitter) that determine -through activation of hard-wired neural circuits -behavioural acceptance or rejection of food 1, 2 . Different classes of tastants are recognised by discrete sensory channels that express distinct, and relatively small, receptor families. For example, detection of all sugars depends upon a single heterodimeric GPCR complex (T1R2/T1R3), while "bitter" cells -which detect an enormous diversity of noxious compounds -co-express a few dozen GPCRs of the T2R family 1, 2 . Such models have been pervasive in interpreting how gustatory perception occurs in other animals, including insects, where analogous segregated sensory pathways for sweet and bitter compounds have been defined [3][4][5][6] . However, in contrast to mammals, where taste -mediated by lingual taste buds -informs only feeding decisions, insect gustation occurs in multiple sensory appendages, including the proboscis, legs, wings and sexual organs, and controls diverse behaviours, such as foraging, feeding, sexual/social recognition and oviposition [3][4][5][6] . In addition to stereotyped appetitive and aversive feeding responses to sweet and bitter compounds respectively, insects display behavioural reactions to many other types of chemicals, including salt 7 , water 8 , carbonation (i.e., aqueous CO 2 ) 9 , organic and inorganic acids 10,11 , and pheromonal cuticular hydrocarbons 12 . The wide-ranging roles of the insect gustatory system are concordantly reflected in the underlying molecular receptors that mediate...

show abstract

The role of the sugar receptor IR60b for Drosophila melanogaster: A hypothesis

Cited by 2 publications

References 5 publications

Modulatory effects of moringa (Moringa oleiferaL.) leaves infested with African mistletoe (Tapinanthus bangwensisL.) on the antioxidant, antidiabetic, and neurochemical indices in high sucrose diet‐induced diabetic‐like phenotype in fruit flies (Drosophila melanogasterM.)

Modulatory effects of moringa (Moringa oleiferaL.) leaves infested with African mistletoe (Tapinanthus bangwensisL.) on the antioxidant, antidiabetic, and neurochemical indices in high sucrose diet‐induced diabetic‐like phenotype in fruit flies (Drosophila melanogasterM.)

An expression atlas of chemosensory ionotropic glutamate receptors identifies a molecular basis of carbonation detection

Contact Info

Product

Resources

About