The role of the synaptic vesicle protein SV2A in regulating mitochondrial morphology and autophagy
Kristina Friedland,
Marko Jörg,
Jonas Reichert
et al.
Abstract:The synaptic vesicle glycoprotein 2A (SV2A) is a transmembrane protein of synaptic vesicles. It is involved in key functions of neurons, focused on the regulation of neurotransmitter release. Here we report three novel findings suggesting a completely new role of SV2A. First, we demonstrate that SV2A is localized at the outer mitochondrial membrane (OMM) using confocal and super-resolution microscopy. Second, Inactivation of SV2A in our cell and animal models leads to fragmented mitochondria. In addition, SV2A… Show more
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