The role of the thalamic nuclei in recognition memory accompanied by recall during encoding and retrieval: An fMRI study

Pergola, Giulio; Ranft, Alexander; Mathias, K.; Suchan, Boris

doi:10.1016/j.neuroimage.2013.02.017

Cited by 68 publications

(69 citation statements)

References 73 publications

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“…Further studies are required to elucidate the possibility of differing roles for the left and right ATN during the resting state. Despite a memory-related role for both the ATN and the DMTN, anatomical studies show that they have different connectivity (Aggleton, 2012), and lesion and imaging studies dissociate their roles during task performance (Pergola et al, 2013; Wolff et al, 2015; Wright et al, 2015; Leszczynski and Staudigl, 2016), which could explain the differing findings for the different nuclei. Specifically, the ATN is thought to play a role in recollection, while the DMTN is a part of a network supporting familiarity (Aggleton et al, 2010; Aggleton, 2012).…”

Section: Discussionmentioning

confidence: 99%

Anterior Thalamic High Frequency Band Activity Is Coupled with Theta Oscillations at Rest

Sweeney‐Reed

Zaehle

Voges

et al. 2017

Front. Hum. Neurosci.

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Cross-frequency coupling (CFC) between slow and fast brain rhythms, in the form of phase–amplitude coupling (PAC), is proposed to enable the coordination of neural oscillatory activity required for cognitive processing. PAC has been identified in the neocortex and mesial temporal regions, varying according to the cognitive task being performed and also at rest. PAC has also been observed in the anterior thalamic nucleus (ATN) during memory processing. The thalamus is active during the resting state and has been proposed to be involved in switching between task-free cognitive states such as rest, in which attention is internally-focused, and externally-focused cognitive states, in which an individual engages with environmental stimuli. It is unknown whether PAC is an ongoing phenomenon during the resting state in the ATN, which is modulated during different cognitive states, or whether it only arises during the performance of specific tasks. We analyzed electrophysiological recordings of ATN activity during rest from seven patients who received thalamic electrodes implanted for treatment of pharmacoresistant focal epilepsy. PAC was identified between theta (4–6 Hz) phase and high frequency band (80–150 Hz) amplitude during rest in all seven patients, which diminished during engagement in tasks involving an external focus of attention. The findings are consistent with the proposal that theta–gamma coupling in the ATN is an ongoing phenomenon, which is modulated by task performance.

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Section: Discussionmentioning

confidence: 99%

Anterior Thalamic High Frequency Band Activity Is Coupled with Theta Oscillations at Rest

Sweeney‐Reed

Zaehle

Voges

et al. 2017

Front. Hum. Neurosci.

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“…They concluded that the parvocellular medio-dorsal nucleus is critical for recall and recollection memory, rather than just contributing to recognition/familiaritybased memory. In a subsequent functional imaging study in healthy participants, Pergola et al (2013) showed that the medio-dorsal thalamic/prefrontal cortical network was activated during successful encoding and retrieval of learned associations, again indicating a role of this system in recall and recollection.…”

Section: Neuroanatomical and Cognitive Considerationsmentioning

confidence: 94%

What does a comparison of the alcoholic Korsakoff syndrome and thalamic infarction tell us about thalamic amnesia?

Kopelman

2015

Neuroscience & Biobehavioral Reviews

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In this review, the clinical, neuropsychological, and neuroimaging findings in the alcoholic Korsakoff syndrome and in thalamic amnesia, resulting from focal infarction, are compared. In both disorders, there is controversy over what is the critical site for anterograde amnesia to occur-damage to the anterior thalamus/mammillo-thalamic tract has most commonly been cited, but damage to the medio-dorsal nuclei has also been advocated. Both syndromes show 'core' features of an anterograde amnesic syndrome; but retrograde amnesia is generally much more extensive (going back many years or decades) in the Korsakoff syndrome. Likewise, spontaneous confabulation occurs more commonly in the Korsakoff syndrome, although seen in only a minority of chronic cases. These differences are attributed to the greater prevalence of frontal atrophy and frontal damage in Korsakoff cases.

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“…To our knowledge, two previous studies have also shown impaired recall using a contextual memory task, although with immediate recall, when the MD is damaged (Soei et al, 2008; Pergola et al, 2012). Alternatively, functional neuroimaging (de Rover et al, 2008; Pergola et al, 2013) has shown that the MD is more involved in recall than recognition. These lesion and fMRI findings dovetail with our current findings, on a group level, showing impaired recall of contextual detail but relatively intact object recognition memory performance.…”

Section: Discussionmentioning

confidence: 99%

“…The specific role of the DLPFC in episodic memory processes is not fully established; however, recent functional neuroimaging evidence has shown that the DLPFC is particularly involved in contextual encoding, especially for the association of between-items compared to associations of within-item features (Blumenfeld et al, 2011). Further, Pergola and colleagues (2013) have shown that the DLPFC and MD are both activated during associative memory retrieval. The contribution of DLPFC and MD connectivity to long-term episodic memory, however, remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion

Miller

Piguet

et al. 2014

Front. Behav. Neurosci.

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Effects of thalamic nuclei damage and related white matter tracts on memory performance are still debated. This is particularly evident for the medio-dorsal thalamus which has been less clear in predicting amnesia than anterior thalamus changes. The current study addresses this issue by assessing 7 thalamic stroke patients with consistent unilateral lesions focal to the left medio-dorsal nuclei for immediate and delayed memory performance on standard visual and verbal tests of anterograde memory, and over the long-term (>24 h) on an object-location associative memory task. Thalamic patients showed selective impairment to delayed recall, but intact recognition memory. Patients also showed accelerated forgetting of contextual details after a 24 h delay, compared to controls. Importantly, the mammillothalamic tract was intact in all patients, which suggests a role for the medio-dorsal nuclei in recall and early consolidation memory processes.

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The role of the thalamic nuclei in recognition memory accompanied by recall during encoding and retrieval: An fMRI study

Cited by 68 publications

References 73 publications

Anterior Thalamic High Frequency Band Activity Is Coupled with Theta Oscillations at Rest

Anterior Thalamic High Frequency Band Activity Is Coupled with Theta Oscillations at Rest

What does a comparison of the alcoholic Korsakoff syndrome and thalamic infarction tell us about thalamic amnesia?

Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion

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