The Role of the Transforming Growth Factor-β Signaling Pathway in Gastrointestinal Cancers

Matsuoka, Tasuku; Yashiro, Masakazu

doi:10.3390/biom13101551

Cited by 6 publications

(2 citation statements)

References 196 publications

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“…TGF-β is a principal effector in GC and regulates the transition of fibroblasts to CAFs, enhancing cell invasion via the promotion of EMT [ 82 , 83 ]. A recent study described that transient receptor potential vanilloid 2 (TRPV2), a highly Ca 2+ -permeable ion channel, enhanced GC cell invasion by upregulation of RUNX2, TGFBR1, and JUN, which were closely related to TGF-β signaling [ 84 ].…”

Section: Signaling Pathways Involved In Gc Invasion and Metastasismentioning

confidence: 99%

Molecular Insight into Gastric Cancer Invasion—Current Status and Future Directions

Matsuoka,

Yashiro

2023

Cancers

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Gastric cancer (GC) is one of the most common malignancies worldwide. There has been no efficient therapy for stage IV GC patients due to this disease’s heterogeneity and dissemination ability. Despite the rapid advancement of molecular targeted therapies, such as HER2 and immune checkpoint inhibitors, survival of GC patients is still unsatisfactory because the understanding of the mechanism of GC progression is still incomplete. Invasion is the most important feature of GC metastasis, which causes poor mortality in patients. Recently, genomic research has critically deepened our knowledge of which gene products are dysregulated in invasive GC. Furthermore, the study of the interaction of GC cells with the tumor microenvironment has emerged as a principal subject in driving invasion and metastasis. These results are expected to provide a profound knowledge of how biological molecules are implicated in GC development. This review summarizes the advances in our current understanding of the molecular mechanism of GC invasion. We also highlight the future directions of the invasion therapeutics of GC. Compared to conventional therapy using protease or molecular inhibitors alone, multi-therapy targeting invasion plasticity may seem to be an assuring direction for the progression of novel strategies.

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Section: Signaling Pathways Involved In Gc Invasion and Metastasismentioning

confidence: 99%

Molecular Insight into Gastric Cancer Invasion—Current Status and Future Directions

Matsuoka,

Yashiro

2023

Cancers

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“…The molecular mechanisms underlying tumor development are highly intricate. For gastrointestinal tumors, comprehending and controlling the heterogeneous molecular mechanisms may unveil novel therapeutic targets ( 1 , 2 ). In recent years, the cancer field, including gastrointestinal tumors, has generated an abundance of molecular and phenotypic data.…”

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confidence: 99%

Editorial: Clinical risk assessment and intervention of gastrointestinal tumors driven by big-data

Zhang,

Wang,

Gao

et al. 2024

Front. Med.

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Establishing a new-onset diabetes-related metabolism signature for predicting the prognosis and immune landscape in pancreatic cancer

Yang,

Liu,

Cui

et al. 2024

Carcinogenesis

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New-onset diabetes (NOD) is a common condition among patients with pancreatic adenocarcinoma (PAAD) and is related to poor clinical outcomes. The potential impact of NOD on PAAD progression and the tumor microenvironment remains unclear. Here, we revealed that NOD in PAAD was associated with metabolic disorders. Utilizing three machine learning algorithms, a new-onset diabetes-related metabolism signature (NRMS) was established. Validated in three independent cohorts, patients with a high NRMS score exhibited worse prognosis. Moreover, an elevated NRMS score was associated with an immunosuppressive microenvironment and diminished response to immunotherapy. Further experiments demonstrated that ALDH3A1, a key feature in NRMS, was significantly up-regulated in tissues from PAAD patients with NOD and played a crucial role in tumor progression and immune suppression. Our findings highlight the potential of NRMS as a prognostic biomarker and an indicator of immunotherapy response for patients with PAAD.

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The Role of the Transforming Growth Factor-β Signaling Pathway in Gastrointestinal Cancers

Cited by 6 publications

References 196 publications

Molecular Insight into Gastric Cancer Invasion—Current Status and Future Directions

Molecular Insight into Gastric Cancer Invasion—Current Status and Future Directions

Editorial: Clinical risk assessment and intervention of gastrointestinal tumors driven by big-data

Establishing a new-onset diabetes-related metabolism signature for predicting the prognosis and immune landscape in pancreatic cancer

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