The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration

Park, Hyun Woo; Song, Min Seok; Sim, Hun Ju; Ryu, Pan Dong; Lee, So Yeong

doi:10.5483/bmbrep.2021.54.2.210

Cited by 19 publications

(10 citation statements)

References 39 publications

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“…Blockade of Kv2.1 results in cell migration inhibition, without affecting cell proliferation. Further experiments suggest that ROS reduction with Nacetyl-l-cysteine or ascorbic acid results in Kv2.1 downregulation [25]. These data suggest that Kv2.1 might be a part of ROS-related signaling and link ROS formation with tumor metastatic potential in prostate cancer.…”

Section: Potassium Channelsmentioning

confidence: 81%

“…Moreover, studies have shown that VGPC-induced electrical excitability in cancer cells affects metastatic invasiveness. It has been suggested that Kv2.1 might play a role in the migration of prostate cancer cells [25]. Increased expression enhances bone marrow mesenchymal stem cell migration under hypoxic preconditioning [26].…”

Section: Potassium Channelsmentioning

confidence: 99%

“…Kv2.1 induces cell motility and focal adhesion kinase activation [26]. Its expression levels and activity are increased in the highly metastatic cell line PC3 compared to other prostate cancer cell lines of lower metastatic potential [25]. Blockade of Kv2.1 results in cell migration inhibition, without affecting cell proliferation.…”

Section: Potassium Channelsmentioning

confidence: 99%

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The Role οf Ion Channels in the Development and Progression of Prostate Cancer

Sakellakis

Chalkias

2023

Mol Diagn Ther

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Numerous studies have firmly established the role of ion channels in essentially all basic cellular functions. Apart from their role in ion transport, they can form macromolecular complexes with adhesion proteins, and signaling molecules. Ion channels are not only responsible for cellular electrogenesis and excitability, but they also regulate the necessary conditions for tissue homeostasis, such as differentiation, proliferation and apoptosis.Although cancer is not officially classified as a channelopathy, it has been increasingly recognized that ion channel aberrations play an important role in virtually all cancer types.Ion channels can exert pro-tumorigenic activities due to genetic or epigenetic alterations, or as a response to molecular signals, such as growth factors, hormones, etc. Prostate cancer is the second leading cause of cancer-related death in men in the United States. Increasing evidence suggests that ion channels and pumps play a critical role in the regulation of prostate cancer cell proliferation, apoptosis evasion, migration, epithelial-to-mesenchymal transition and angiogenesis. There is also evidence suggesting that ion channels might play a role in treatment failure in prostate cancer. Hence, they represent promising targets for diagnosis, staging and treatment. Here, the role of major types of ion channels involved in the development and progression of prostate cancer were reviewed. Identifying the

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Section: Potassium Channelsmentioning

confidence: 81%

Section: Potassium Channelsmentioning

confidence: 99%

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The Role οf Ion Channels in the Development and Progression of Prostate Cancer

Sakellakis

Chalkias

2023

Mol Diagn Ther

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“…The expression of the Kv2.1 channel recently was reported to be higher in the metastatic prostate cancer cells (PC3), and their blockade with stromatoxin-1 or siRNA significantly inhibits the migration of malignant prostate cancer cells. 51 This channel as Kv1.4, Kv4.2, Kv7.1 and large-conductance Ca 2+ -activated K + channel (BK Ca ) also showed a high expression in the CD133 + subpopulation of SH-SY5Y neuroblastoma cells. 52 Increased levels of Kv3.4 channel expression were identified in OSCC (oral squamous cell carcinoma).…”

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confidence: 99%

Potassium Channels as a Target for Cancer Therapy: Current Perspectives

Zúñiga¹,

Cayo²,

González³

et al. 2022

OTT

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Potassium (K + ) channels are highly regulated membrane proteins that control the potassium ion flux and respond to different cellular stimuli. These ion channels are grouped into three major families, Kv (voltage-gated K + channel), Kir (inwardly rectifying K + channel) and K2P (two-pore K + channels), according to the structure, to mediate the K + currents. In cancer, alterations in K + channel function can promote the acquisition of the so-called hallmarks of cancer – cell proliferation, resistance to apoptosis, metabolic changes, angiogenesis, and migratory capabilities – emerging as targets for the development of new therapeutic drugs. In this review, we focus our attention on the different K + channels associated with the most relevant and prevalent cancer types. We summarize our knowledge about the potassium channels structure and function, their cancer dysregulated expression and discuss the K + channels modulator and the strategies for designing new drugs.

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“…For example, voltage-gated sodium channels (VGSCs) can enhance extracellular matrix (ECM) degradation and facilitate the metastasis of various carcinomas (15)(16)(17)(18). Meanwhile, the role of K v channels in tumour proliferation and growth has been demonstrated as applicable to a variety of cancer, including prostate cancer, colon cancer, lung cancer, and breast cancer (19)(20)(21)(22)(23). Therefore, regulating the activity of ion channels is one of the viable solutions for the anticancer treatment.…”

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confidence: 99%

The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K⁺ channels

et al. 2023

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Voltage-gated K+ (Kv) channels play a role in the cellular processes of various cancer cells, including lung cancer cells. We previously identified and reported a salivary protein from the Xenopsylla cheopis, FS48, which exhibited inhibitory activity against Kv1.1-1.3 channels when assayed in HEK 293T cells. However, whether FS48 has an inhibitory effect on cancer cells expressing Kv channels is unclear. The present study aims to reveal the effects of FS48 on the Kv channels and the NCI-H460 human lung cancer cells through patch clamp, MTT, wound healing, transwell, gelatinase zymography, qRT-PCR and WB assays. The results demonstrated that FS48 can be effective in suppressing the Kv currents, migration, and invasion of NCI-H460 cells in a dose-dependent manner, despite the failure to inhibit the proliferation. Moreover, the expression of Kv1.1 and Kv1.3 mRNA and protein were found to be significantly reduced. Finally, FS48 decreases the mRNA level of MMP-9 while increasing TIMP-1 mRNA level. The present study highlights for the first time that blood-sucking arthropod saliva-derived protein can inhibit the physiological activities of tumour cells via the Kv channels. Furthermore, FS48 can be taken as a hit compound against the tumour cells expressing Kv channels.

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The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration

Cited by 19 publications

References 39 publications

The Role οf Ion Channels in the Development and Progression of Prostate Cancer

The Role οf Ion Channels in the Development and Progression of Prostate Cancer

Potassium Channels as a Target for Cancer Therapy: Current Perspectives

The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K⁺ channels

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The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration

Cited by 19 publications

References 39 publications

The Role οf Ion Channels in the Development and Progression of Prostate Cancer

The Role οf Ion Channels in the Development and Progression of Prostate Cancer

Potassium Channels as a Target for Cancer Therapy: Current Perspectives

The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K+ channels

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The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K⁺ channels