The role of thiamine as a resuscitator in patients with nonalcoholic medical and CNS disorders

Shehabeldin, Mohamed

doi:10.12746/swrccc.v5i19.398

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Converted into its active form, thiamine pyrophosphate, vitamin B1 is an essential cofactor in two carbohydrate metabolic pathways: the Krebs cycle and the pentose phosphate pathway (PPP) [8]. In the Krebs cycle, thiamine is an essential cofactor for two major enzymes, the pyruvate dehydrogenase complex (PDH) and α-ketoglutarate dehydrogenase (α-KGDH) [21,22]. The reduction of ATP production in the brain results in increased production of toxic dopamine metabolites and inhibition of the enzyme that synthesises and breaks down dopamine in the subfrontal cortex.…”

Section: Thiamine and Delirium-pathophysiologymentioning

confidence: 99%

“…Another association with increased cognitive impairment and delirium is low levels of acetylcholine, which is linked to PDH function [22]. PDH is involved in the production of the neurotransmitter acetylcholine and in the synthesis of myelin [21]. The Krebs cycle and α-KGDH are also involved in maintaining levels of gamma-aminobutyric acid (GABA), glutamate, and aspartate [23].…”

Section: Thiamine and Delirium-pathophysiologymentioning

confidence: 99%

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Delirium in Critical Illness Patients and the Potential Role of Thiamine Therapy in Prevention and Treatment: Findings from a Scoping Review with Implications for Evidence-Based Practice

Lange¹,

Mędrzycka‐Dąbrowska

Friganović

et al. 2021

IJERPH

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Introduction: Thiamine is a water-soluble vitamin and is necessary for energy metabolism. Critically ill patients are at particular risk of developing thiamine deficiency and related complications. One of the complications that can occur is delirium. Delirium is a disorder that affects the body’s response to treatment, length of stay in the ward, mortality, long-term cognitive impairment, and significantly increases treatment costs. In addition, studies show that delirium medication is more effective in preventing than in treating delirium. Given its low cost, availability, and minimal risk of side effects, thiamine supplementation could prove to be a relevant strategy in the prevention and treatment of delirium. Methods: PubMed, Cochrane Library, Ovid, and ClinicalTrials.gov databases were searched using relevant keywords that focus on the use of thiamine to prevent or treat delirium in critically ill patients. Results: Seven articles were included in the analysis. Conclusion: The small number of studies and considerable heterogeneity prevent conclusions supporting the use of thiamine as an adjuvant in the prevention and treatment of delirium among critically ill patients. There is a need for high-quality, large-scale randomized clinical trials to confirm the beneficial effects of thiamine in the prevention and treatment of delirium.

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Section: Thiamine and Delirium-pathophysiologymentioning

confidence: 99%