The role of thyroid hormone in the renal immune microenvironment

Han, Zhongyu; Chen, Liuyan; Peng, Hongyao; Zheng, Haibin; Lin, Yumeng; Peng, Fang Zheng; Fan, Yunhe; Xie, Xianhe; Yang, Simin; Wang, Zhanzhan; Liu, Yuan; Wei, Xiuyan; Chen, Haoran

doi:10.1016/j.intimp.2023.110172

Cited by 7 publications

(1 citation statement)

References 139 publications

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“…Thyroid hormones serve as crucial regulators of growth, development, and overall homeostasis in vertebrates [ 96 , 97 , 98 ]. The process of deiodination, facilitated by the enzyme deiodinase (DIO1), plays a fundamental role in regulating the concentration of thyroid hormones in peripheral tissues and plasma [ 99 , 100 ].…”

Section: Need For New Methodsmentioning

confidence: 99%

Advancing Endocrine Disruptors via In Vitro Evaluation: Recognizing the Significance of the Organization for Economic Co-Operation and Development and United States Environmental Protection Agency Guidelines, Embracing New Assessment Methods, and the Urgent Need for a Comprehensive Battery of Tests

Fouyet,

Ferger,

Leproux

et al. 2024

Toxics

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Efforts are being made globally to improve the evaluation and understanding of endocrine-disrupting chemicals. Recognition of their impact on human health and the environment has stimulated attention and research in this field. Various stakeholders, including scientists, regulatory agencies, policymakers, and industry representatives, are collaborating to develop robust methodologies and guidelines for assessing these disruptors. A key aspect of these efforts is the development of standardized testing protocols and guidelines that aim to provide consistent and reliable methods for identifying and characterizing endocrine disruptors. When evaluating the potential endocrine-disrupting activity of chemicals, no single test is capable of detecting all relevant endocrine-disrupting agents. The test battery approach is designed to reduce the risk of false negative results for compounds with toxic potential. A weight-of-evidence approach is therefore necessary for endocrine disruptor evaluation. This approach considers various types of data from multiple sources, assessing the overall strength, consistency, and reliability of the evidence. OECD guidelines are highly regarded for their scientific rigor, transparency, and consensus-based development process. It is crucial to explore and develop new methodologies that can effectively evaluate the risks associated with potential endocrine disruptors. Integrating these methods into a comprehensive weight-of-evidence framework will enhance risk assessments and facilitate informed decisions regarding the regulation and management of these substances, ensuring the protection of human health and the environment from their adverse effects.

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Section: Need For New Methodsmentioning

confidence: 99%

Advancing Endocrine Disruptors via In Vitro Evaluation: Recognizing the Significance of the Organization for Economic Co-Operation and Development and United States Environmental Protection Agency Guidelines, Embracing New Assessment Methods, and the Urgent Need for a Comprehensive Battery of Tests

Fouyet,

Ferger,

Leproux

et al. 2024

Toxics

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Unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance

Deng,

Gu,

et al. 2024

Discov Onc

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The gut microbiota (GM) and immune cells (IC) are increasingly recognized as key players in cancer development and progression. This study aimed to explore the potential mediating role of IC in the causal relationship between GM and thyroid cancer (TC) using Mendelian randomization (MR) analysis. Data from genome-wide association studies (GWAS) encompassing 473 GM species, 731 IC types, and TC were utilized. MR analysis identified nine GM species with significant causal relationships to TC, mediated by 10 IC phenotypes such as "Switched Memory AC," "IgD-CD38dim AC," and "EM DN (CD4-CD8-) AC." These findings suggest a complex interplay where specific IC mediate the effects of GM on TC risk. Sensitivity analyses confirmed the robustness of these results, with no evidence of horizontal pleiotropy. This study highlights potential mechanisms linking GM and IC to TC, offering insights that could inform GM-based immunotherapeutic strategies and IC-targeted interventions. However, further experimental research is needed to validate these causal pathways and better understand the underlying biological mechanisms. Supplementary Information The online version contains supplementary material available at 10.1007/s12672-024-01585-x.

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Impaired sensitivity to thyroid hormones is associated with albuminuria in the euthyroid population: results from NHANES

Wang,

Wu,

Pan

et al. 2024

Hormones

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The role of thyroid hormone in the renal immune microenvironment

Cited by 7 publications

References 139 publications

Advancing Endocrine Disruptors via In Vitro Evaluation: Recognizing the Significance of the Organization for Economic Co-Operation and Development and United States Environmental Protection Agency Guidelines, Embracing New Assessment Methods, and the Urgent Need for a Comprehensive Battery of Tests

Advancing Endocrine Disruptors via In Vitro Evaluation: Recognizing the Significance of the Organization for Economic Co-Operation and Development and United States Environmental Protection Agency Guidelines, Embracing New Assessment Methods, and the Urgent Need for a Comprehensive Battery of Tests

Unraveling the role of gut microbiota and immune cells in thyroid cancer and tumor drug resistance

Impaired sensitivity to thyroid hormones is associated with albuminuria in the euthyroid population: results from NHANES

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