The role of thyroid-stimulating hormone in regulating lipid metabolism: Implications for body–brain communication

Wang, Xueqin; Wu, Zhen; Liu, Yuting; Wu, Chengxi; Jiang, Jun; Hashimoto, Kenji; Zhou, Xiangyu

doi:10.1016/j.nbd.2024.106658

Neurobiology of Disease

2024

DOI: 10.1016/j.nbd.2024.106658

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The role of thyroid-stimulating hormone in regulating lipid metabolism: Implications for body–brain communication

Xueqin Wang,

Zhen Wu,

Yuting Liu

et al.

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2024

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Cited by 2 publications

References 172 publications

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Special issue on “A focus on brain–body communication in understanding the neurobiology of diseases”

Hashimoto,

Wei,

Yang

2024

Neurobiology of Disease

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Special issue on “A focus on brain–body communication in understanding the neurobiology of diseases”

Hashimoto,

Wei,

Yang

2024

Neurobiology of Disease

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Application of Human Plasma Targeted Lipidomics and Analysis of Toxic Elements to Capture the Metabolic Complexities of Hypothyroidism

Błażewicz,

Kiełbus,

Skórzyńska-Dziduszko

et al. 2024

Molecules

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Background: Hypothyroidism (HT) affects millions worldwide and can lead to various lipid disorders. The metabolic complexity and the influence of toxic elements in autoimmune and non-autoimmune HT subtypes are not fully understood. This study aimed to investigate the relationships between plasma lipidome, toxic elements, and clinical classifications of HT in unexposed individuals. Methods: Samples were collected from 120 adults assigned to a study group with Hashimoto’s disease and non-autoimmune HT, and a healthy control group. Quantification of 145 pre-defined lipids was performed by using triple quadrupole tandem mass spectrometry (TQ MS/MS) in multiple reactions monitoring (MRM) mode via positive electrospray ionization (ESI). Levels of toxic elements were determined using inductively coupled plasma mass spectrometry (ICP-MS). Results: Significant associations between altered levels of several components of the plasma lipidome and Al, Cd, Ni, As, and Pb with HT were found. We show metabolic differences in lysophosphatidylcholines (LPC) and phosphatidylcholines (PC) between HT and controls, with distinct predicted activation patterns for lysolecithin acyltransferase and phospholipase A2. Conclusions: There are significant changes in the lipidome profiles of healthy subjects compared to euthyroid HT patients treated with L-thyroxine, which are related to the type of hypothyroidism and non-occupational exposure to toxic elements.

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The role of thyroid-stimulating hormone in regulating lipid metabolism: Implications for body–brain communication

Cited by 2 publications

References 172 publications

Special issue on “A focus on brain–body communication in understanding the neurobiology of diseases”

Special issue on “A focus on brain–body communication in understanding the neurobiology of diseases”

Application of Human Plasma Targeted Lipidomics and Analysis of Toxic Elements to Capture the Metabolic Complexities of Hypothyroidism

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