2024
DOI: 10.3389/fimmu.2024.1328667
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The role of TIM-3 in sepsis: a promising target for immunotherapy?

Changli Wang,
Jinhai Liu,
Qi Wu
et al.

Abstract: Sepsis remains a significant cause of mortality and morbidity worldwide, with limited effective treatment options. The T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) has emerged as a potential therapeutic target in various immune-related disorders. This narrative review aims to explore the role of TIM-3 in sepsis and evaluate its potential as a promising target for immunotherapy. We discuss the dynamic expression patterns of TIM-3 during sepsis and its involvement in regulating immune res… Show more

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