The role of tissue factor and tissue factor pathway inhibitor in health and disease states

DelGiudice, Louis A.; White, G. A.

doi:10.1111/j.1476-4431.2008.00380.x

Cited by 27 publications

(27 citation statements)

References 71 publications

(187 reference statements)

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“…TF is the primary physiologic initiator of coagulation and is not normally expressed by cells that are in direct contact with blood. However endothelial cells, neutrophils and monocytes express TF on their surfaces in response to a variety of stimuli, including endotoxin, interleukin-6 (IL-6), tumor necrosis factor (TNF), IL-1 and immune complexes (Brady and Otto, 2001;DelGiudice and White, 2009;Hoffman and Monroe, 2001;Weiss and Rashid, 1998). TF thus plays an important role in the initiation of inflammationinduced coagulation (Levi et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Mortality in virulent canine babesiosis is associated with a consumptive coagulopathy

Goddard¹,

Wiinberg²,

Schoeman³

et al. 2013

The Veterinary Journal

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The inflammatory response to infection can activate the coagulation system via complex interactions. If uncontrolled, this may lead to a consumptive coagulopathy, which has been identified as a major risk factor for poor outcome in both human and canine medicine. This study was undertaken to prospectively determine whether the presence of a consumptive coagulopathy in dogs with Babesia rossi infection is related to mortality. A prospective, cross-sectional, observational study was performed. Seventy-two client-owned dogs diagnosed with canine babesiosis were included. Diagnosis was confirmed by polymerase chain reaction and reverse line blot and dogs infected with Babesia vogeli or Ehrlichia canis were excluded. Blood samples were collected at admission. Coagulation factor-, antithrombin (AT)-, and protein C (PC) activity, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen and Ddimer concentrations were measured. The mortality rate was 18% (13/72) and results between non-survivors and survivors were compared. The median activities of all the coagulation factors were significantly lower in the non-survivors compared to the survivors. The median PT and aPTT were significantly longer in the non-survivors compared to the survivors. The median AT activity was not significantly different; however, the median PC activity was significantly 2 decreased in the non-survivors. The median D-dimer concentration was significantly higher in the non-survivors compared to the survivors. This study showed that dogs that died from B.canis infection suffered from a more severe consumptive coagulopathy compared to survivors, characterized by procoagulant activation, inhibitor consumption, and increased fibrinolytic activity.

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Section: Discussionmentioning

confidence: 99%

Mortality in virulent canine babesiosis is associated with a consumptive coagulopathy

Goddard¹,

Wiinberg²,

Schoeman³

et al. 2013

The Veterinary Journal

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“…The first stage, in the inhibitory function of TFPI, involves reversible inhibition of FXa. The second step depends on binding TFPI/FXa to the TF/VIIa complex, hence inhibiting thrombin generation (DelGiudice and White, 2009;Chu, 2011). Moreover, TFPI is able to influence cell proliferation and a proper function of the endothelial cells (Opstad et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Protease-activated receptors (PARs) on endothelial cells, co-expressed with TF, take part in processes such as inflammatory responses, atherosclerosis, tumor metastasis, and angiogenesis (DelGiudice and White, 2009;Chu, 2011). Moreover, a high level of TF/VIIa complex induces vascular endothelial growth factor (VEGF) production via PAR-2 signaling (DelGiudice and White, 2009;Chu, 2011;Kota et al, 2012). In a chronic hyperglycemic condition, angiogenesis is controlled in organ, tissue, and cell type-specific pathways.…”

Section: Introductionmentioning

confidence: 99%

Low-grade risk of hypercoagulable state in patients suffering from diabetes mellitus type 2

Ruszkowska-Ciastek

Sokup

Wernik

et al. 2015

J. Zhejiang Univ. Sci. B

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Abstract:Objective: Diabetes, including type 1 and type 2, is associated with the hypercoagulable state. The aim of this study is to evaluate the concentration of selected hemostatic parameters and vascular endothelial growth factor-A (VEGF-A) in diabetic subjects. Methods: The study was conducted in 62 patients with diabetes. Group I consisted of 27 patients having uncontrolled diabetes with microalbuminuria and Group II included 35 well-controlled diabetic patients. The control group was made up of 25 healthy volunteers. In the citrate plasma, the concentrations of tissue factor (TF), tissue factor pathway inhibitor (TFPI), thrombin-antithrombin (TAT) complexes, and D-dimer were assayed. Serum concentrations of VEGF-A, lipid profile, creatinine, and plasma fasting glucose were measured and in the versene plasma the concentration of HbA1c was determined. Results: In the patients with uncontrolled diabetes, higher concentrations of TF, TFPI, and VEGF-A were observed, as compared with the well-controlled diabetics group and the control group. A significantly lower activity of antiplasmin was reported in patients from Group I as compared with the control group. In Group I, using the multivariate regression analysis, the glomerular filtration rate was independently associated with VEGF-A and dependently associated with total cholesterol. Conclusions: The study showed higher concentrations of TF and TFPI in the patients with uncontrolled diabetes with microalbuminuria, which is associated with rapid neutralization of the thrombin formation, since TFPI inhibits the complex of TF/VIIa/Ca 2+ . The manifestation of the above suggestions is the correct TAT complexes and D-dimer, which indicates a low grade of prothrombotic risk in this group of patients, but a higher risk of vascular complications.

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“…TFPI is expressed primarily in the microvessels; thus, it might only nominally participate in hemostasis balancing in the larger vessels. Apparently, this pathway only slightly contributes to the coagulation/inflammation cross-over (DelGiudice & White, 2009). The PC anticoagulant system is more extensively present in the vascular network (Viles-Gonzalez et al, 2005).…”

Section: Pro-inflammatory Environment Sustains Coagulationmentioning

confidence: 99%

“…It should be noted that TNFand IL-1ß are produced by lymphocytes and macrophages during vascular inflammation, and these events can also enhance the expression of the TF. The TF expression can be stimulated by several inflammatory mediators, namely TNF-, IL-1, IL-6, activated complement, and immune complexes (DelGiudice & White, 2009). Activated T cells increase both TF expression and activity via paracrine stimulation of endothelial cells (Monaco et al, 2002).…”

Section: Pro-inflammatory Environment Sustains Coagulationmentioning

confidence: 99%

Hemostatic Soluble Plasma Proteins During Acute-Phase Response and Chronic Inflammation

Patalakh¹

2011

Acute Phase Proteins - Regulation and Functions of Acute Phase Proteins

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The role of tissue factor and tissue factor pathway inhibitor in health and disease states

Cited by 27 publications

References 71 publications

Mortality in virulent canine babesiosis is associated with a consumptive coagulopathy

Mortality in virulent canine babesiosis is associated with a consumptive coagulopathy

Low-grade risk of hypercoagulable state in patients suffering from diabetes mellitus type 2

Hemostatic Soluble Plasma Proteins During Acute-Phase Response and Chronic Inflammation

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