The Role of Tissue Inhibitor of Metalloproteinase-1 and 2 in Echinococcus granulosus senso lato-Induced Human Hepatic Fibrosis

Hasanzadeh, Azadeh; Rafiei, Alireza; Kazemi, Mohammad; Beiromvand, Molouk; Bahreini, Amin; Khanahmad, Hossein

doi:10.1007/s11686-022-00534-4

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Fibrosis is characterized by ECM deposition due to the overproduction of ECM and the inhibition of ECM degradation. Many fibrotic events, such as vascular endothelial dysfunction and immune abnormalities, are associated with the activation and differentiation of myofibroblasts and the inhibition of ECM-depredating proteases, including MMPs and plasmin, which cause ECM deposition [ 9 , 11 , 64 , 65 , 66 , 67 ].…”

Section: The Role Of the Upa/upar System In Fibrosismentioning

confidence: 99%

“…TIMPs are secreted by various cells, including immune cells, fibroblasts, and hepatocytes, and tumor necrosis factor-α (TNF-α) and prostaglandin E2 (PGE2) induce TIMP expression [ 10 , 18 , 141 , 142 ]. TIMP-1 and TIMP-2 levels are elevated in several types of fibrosis, including SSc, pulmonary fibrosis, liver cirrhosis, renal fibrosis, and myocardial fibrosis [ 14 , 18 , 65 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 ]. α2AP is elevated in fibrotic tissue, including skin and renal fibrosis [ 21 , 22 , 151 ].…”

Section: The Role Of the Upa/upar System In Fibrosismentioning

confidence: 99%

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The uPA/uPAR System Orchestrates the Inflammatory Response, Vascular Homeostasis, and Immune System in Fibrosis Progression

Kanno

2023

IJMS

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Fibrotic diseases, such as systemic sclerosis (SSc), idiopathic pulmonary fibrosis, renal fibrosis and liver cirrhosis are characterized by tissue overgrowth due to excessive extracellular matrix (ECM) deposition. Fibrosis progression is caused by ECM overproduction and the inhibition of ECM degradation due to several events, including inflammation, vascular endothelial dysfunction, and immune abnormalities. Recently, it has been reported that urokinase plasminogen activator (uPA) and its receptor (uPAR), known to be fibrinolytic factors, orchestrate the inflammatory response, vascular homeostasis, and immune homeostasis system. The uPA/uPAR system may show promise as a potential therapeutic target for fibrotic diseases. This review considers the role of the uPA/uPAR system in the progression of fibrotic diseases.

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Section: The Role Of the Upa/upar System In Fibrosismentioning

confidence: 99%

Section: The Role Of the Upa/upar System In Fibrosismentioning

confidence: 99%

The uPA/uPAR System Orchestrates the Inflammatory Response, Vascular Homeostasis, and Immune System in Fibrosis Progression

Kanno

2023

IJMS

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Expression of Matrix Metalloproteinases in Human Cystic Echinococcosis

Hasanzadeh

Beiromvand

Rafiei

et al. 2024

CMM

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Background: Cystic echinococcosis (CE) is a zoonotic disease caused by the Echinococcus granulosus senso lato (E. granulosus s.l.) larval stages. Parasite-derived products have been shown to regulate host matrix metalloproteinases (MMPs), contributing to CE pathogenesis and progressive liver fibrosis in intermediate hosts. The current study aimed to investigate the potential role of MMP1, 7, 8, and 13 in E. granulosus s.l-¬induced liver fibrosis. Methods: Thirty CE patients with active, transitional, or inactive hydatid cysts were enrolled in this study using qRT-PCR to determine the inductive effects of E. granulosus on the expression of MMP-1, MMP-7, MMP-8, and MMP-13 in healthy liver tissue and fibrotic liver tissue. Results: According to the WHO-IWGE classification, patients with functional cysts (CE1 and CE2) had the highest percentage (46.6%). MMP-1, MMP-7, MMP-8, and MMP-13 expression levels were significantly higher in fibrotic liver than in normal liver tissue. MMP-13 and MMP-1 had the highest and lowest expression levels among MMPs. Compared to the normal group, the fold change for MMP-13 in the fibrotic group was greater than 12 and had the highest AUC value (AUC= 0.8283). Conclusions: Our findings suggest that E. granulosus-derived products might be involved in regulating host MMPs. Thus, MMPs may be considered potential biomarkers for predicting CE prognosis. Because of the non-normal distribution of our patients’ CE types, further research, particularly on circulation MMPs, is needed to confirm the potential role of MMPs in CE pathogenesis and to follow up on CE patients.

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The Role of Tissue Inhibitor of Metalloproteinase-1 and 2 in Echinococcus granulosus senso lato-Induced Human Hepatic Fibrosis

Cited by 2 publications

References 25 publications

The uPA/uPAR System Orchestrates the Inflammatory Response, Vascular Homeostasis, and Immune System in Fibrosis Progression

The uPA/uPAR System Orchestrates the Inflammatory Response, Vascular Homeostasis, and Immune System in Fibrosis Progression

Expression of Matrix Metalloproteinases in Human Cystic Echinococcosis

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