2024
DOI: 10.3390/ijms252212331
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The Role of TNF Receptor-Associated Factor 5 in the Formation of Germinal Centers by B Cells During the Primary Phase of the Immune Response in Mice

Mari Hikosaka-Kuniishi,
Chieri Iwata,
Yusuke Ozawa
et al.

Abstract: TNF receptor-associated factors (TRAFs) function as intracellular adaptor proteins utilized by members of the TNF receptor superfamily, such as CD40. Among the TRAF family proteins, TRAF5 has been identified as a potential regulator of CD40. However, it remains unclear whether TRAF5 regulates the generation of germinal center (GC) B cells and antigen-specific antibody production in the T-dependent (TD) immune response. TRAF5-deficient (Traf5−/−) and TRAF5-sufficient (Traf5+/+) mice were immunized in the footpa… Show more

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