The Role of Toll-Like Receptors in the Pathogenesis of Renal Disease

Czyzyk, Jan

doi:10.1016/j.semnephrol.2005.09.007

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…Patients with a loss of function in the TLR4 gene are more susceptible to infections with Gram-negative bacteria (14). It has also been shown that Tamm-Horsfall protein activates APCs via a TLR4-dependent mechanism (15).…”

Section: Toll-like Receptorsmentioning

confidence: 99%

Aspects of Immune Dysfunction in End-stage Renal Disease

Kato

Chmielewski

Honda

et al. 2008

Clinical Journal of the American Society of Nephrology

926

716

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End-stage renal disease (ESRD) is associated with significantly increased morbidity and mortality resulting from cardiovascular disease (CVD) and infections, accounting for 50% and 20%, respectively, of the total mortality in ESRD patients. It is possible that these two complications are linked to alterations in the immune system in ESRD, as uremia is associated with a state of immune dysfunction characterized by immunodepression that contributes to the high prevalence of infections among these patients, as well as by immunoactivation resulting in inflammation that may contribute to CVD. This review describes disorders of the innate and adaptive immune systems in ESRD, underlining the specific role of ESRD-associated disturbances of Toll-like receptors. Finally, based on the emerging links between the alterations of immune system, CVD, and infections in ESRD patients, it emphasizes the potential role of the immune dysfunction in ESRD as an underlying cause for the high mortality in this patient population and the need for more studies in this area.

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Section: Toll-like Receptorsmentioning

confidence: 99%

Aspects of Immune Dysfunction in End-stage Renal Disease

Kato

Chmielewski

Honda

et al. 2008

Clinical Journal of the American Society of Nephrology

926

716

View full text Add to dashboard Cite

show abstract

“…Higher expression of MHC II and/or BAFF in the lymph nodes and spleen could permit communication with T and B cells (Charles et al 2010). Activation of TLR pathways has been implicated in various renal diseases, including acute kidney injury, ischemia-reperfusion injury, allograft rejection and immune complex nephritis (Czyzyk 2006). The circulating immune complexes in autoimmune kidney disease bind to specific receptors on cell surfaces such as Fcγ receptors (FcγR) and TLRs activate cells (Gollapudi et al 2010).…”

Section: Basophil Function In Ckdmentioning

confidence: 99%