The role of trace elements for the health of elderly individuals

Ekmekçioğlu, Cem

doi:10.1002/1521-3803(20011001)45:5<309::aid-food309>3.0.co;2-0

Cited by 54 publications

(24 citation statements)

References 61 publications

(67 reference statements)

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“…Although energy requirement decreases with age, the need for antioxidants generally stays the same (Food and Nutrition Board, 2000). Moreover, elderly individuals have a higher incidence of chronic diseases and often use therapeutic drugs both of which can impair the appetite and/or affect nutrient utilization (Schumann, 1999;Ekmekcioglu, 2001). Therefore, we hypothesized that even well-educated younger female seniors may exhibit an insufficient antioxidant status.…”

Section: Introductionmentioning

confidence: 99%

Selenium and antioxidant vitamin status of elderly German women

et al. 2005

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Objective: Low antioxidant intake and status have been shown to be associated with an elevated risk for various diseases. Data on the status of antioxidant vitamins, selenium and coenzyme Q10 of younger female seniors are scarce. The aim of this study was to assess the status of these antioxidants, as well as influencing factors such as dietary intake, anthropometric data and educational level in female seniors (60-70 years) in Germany. Design: Dietary intake of alpha-tocopherol, beta-carotene and ascorbic acid was determined by a 3-day diet record. Serum concentrations of alpha-tocopherol, beta-carotene, ascorbic acid, selenium and coenzyme Q10 were measured. Anthropometric measures, socioeconomic and educational status were assessed. Setting: In total, 178 elderly women without severe diseases in the region of Hannover, Germany, were included in the study. The mean (7s.d.) age and BMI of the women was 63.2 (2.73) years and 25.6 (3.77) kg/m 2 , respectively. The study participants were generally better educated than the overall German female population. Results: Dietary intake of the ascorbic acid and alpha-tocopherol was below RDA in six and 75% of the women, respectively. In comparison to estimated desirable serum concentrations of alpha-tocopherol, ascorbic acid, beta-carotene and selenium, lower concentrations were found in 23, 1, 6, and 39% of the women, respectively. Ascorbic acid (r ¼ 0.205, P ¼ 0.009) and betacarotene (r ¼ 0.173, P ¼ 0.025) intake were significantly associated with serum concentrations. Beta-carotene concentrations were influenced by the type of diet, BMI, and school education (R 2 ¼ 0.128, Po0.001). Serum selenium was positively associated with alcohol intake (r ¼ 0.229, P ¼ 0.003). Neither employment nor vocational training was predictive for the serum concentrations of antioxidant vitamins, selenium or coenzyme Q10. Conclusions: Poor status of selenium and alpha-tocopherol is highly prevalent even among younger, well-educated female seniors, whereas ascorbic acid and beta-carotene status seems sufficient in most women.

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Section: Introductionmentioning

confidence: 99%

Selenium and antioxidant vitamin status of elderly German women

et al. 2005

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“…Due to lifestyle, eating, and dietary habits, and physiological effects of aging, the elderly male population is normally predisposed to conditions of Zn deficiency (Mocchegiani et al 2000;Ekmekcioglu 2001;High 2001;Padro et al 2002;Vaquero 2002), which can increase this population's susceptibility to BPH. Since iodine deficiency can make the thyroid gland expand in size, it is thought that a Zn deficiency may also cause the prostate gland to increase in size.…”

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confidence: 99%

Age-related histological and zinc content changes in adult nonhyperplastic prostate glands

Zaichick

2013

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To clarify age-related histological and Zn content changes in nonhyperplastic adult prostate glands, a quantitative morphometric and energy-dispersive X-ray fluorescence analyses were performed. The prostates were obtained from autopsies of 63 subjects aged 21-70 years who died mainly from trauma. It was found that histologically normal prostate tissue undergoes substantial changes throughout aging. These changes are reflected in an increase of the percent volume of the glandular lumen for the third to fifth decades, reaching a maximum for the decade 41-50 years. Over the same period, the percent volume of the stroma remains steady, but the percent volume of epithelium decreases, approximately, linearly with age. The percent volume of glandular lumen (reflects the volume of prostatic fluid) in the prostate gland of men aged 41 to 50 years is 1.5-fold higher than that in men aged 21 to 30 years, but the epithelium/lumen (prostatic fluid) ratio is approximately twofold lower. This suggests that accumulation of the prostatic fluid develops from 30 to 50 years of age. This accumulation of the prostatic fluid results in an increase of the Zn mass fraction in the prostate. In turn, when the intraprostatic Zn level exceeds a certain level by the end of the fifth decade, it begins to work as a trigger for different factors, all of which increase the proliferation of stromal cells. Deductions from these results allow possible partial explanations of both relevant prostatic aging mechanisms and the effects of dietary interventions using supplementary Zn.

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“…One is that lipidperoxides accumulate with age (26), which may cause a decrease in body selenium status. Furthermore, elderly people have a generally higher risk to develop selenium nutrition deficiency due to modified dietary habits and requirement, decreased physical activity, age-related physiological changes, drug therapy and chronic disease (43,44).…”

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confidence: 99%