The role of trachelectomy in cervical cancer

Halaška, M; Robová, Helena; Pluta, Marek; Rob, Lukáš

doi:10.3332/ecancer.2015.506

Cited by 25 publications

(22 citation statements)

References 41 publications

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“…first reported vaginal radical trachelectomy (RT) in 1994, trachelectomy has been increasingly used, and other approaches, such as abdominal, laparoscopic, and robotic procedures have been developed. At present, >900 cases of trachelectomy have been reported in the literature . Since 2010, we have performed abdominal RT (ART) in 28 patients.…”

Section: Introductionmentioning

confidence: 99%

Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single‐institution experience

Tamauchi

Kajiyama

Sakata

et al. 2016

J of Obstet and Gynaecol

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Aim: Radical trachelectomy (RT) is a widely used fertility-sparing treatment for patients with early cervical cancer (CCA). RT, however, is an investigational treatment, and its gynecological and obstetric efficacy are being investigated. We retrospectively assessed the efficacy of abdominal RT (ART) as a fertility-sparing surgery. Methods: From 2010 to 2014, patients with stage IA2-IB1 CCA (tumor ≤2 cm) who wished to preserve their fertility underwent ART. The major outcomes were mortality, recurrence, pregnancy complications, and obstetric outcome. Results: Twenty-eight patients received ART. Adjuvant chemotherapy was performed in seven patients because of lymphovascular space invasion. During the median follow-up of 43 months, no recurrences occurred. Twelve women attempted to conceive, and eight of them became pregnant. A total of five children were born, and one baby was full term. Three cases of second trimester, and one case of third trimester preterm births were recorded. Conclusions: Fertility was preserved after ART in a moderate number of patients. The pregnancy and birth rates after ART have been improving, and increasing the full-term birth rate is the next goal. In addition, development of further types of minimally invasive surgery for CCA can be expected.

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Section: Introductionmentioning

confidence: 99%

Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single‐institution experience

Tamauchi

Kajiyama

Sakata

et al. 2016

J of Obstet and Gynaecol

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“…16,17 The same may be achieved with radical vaginal trachelectomy. 11,19,20 Although associated with lower morbidity compared with type III radical hysterectomy, the morbidity related to parametrial excision is above that of simple hysterectomy. 4,6,28 Management of the parametrium is also important in the treatment of patients requesting fertility preservation.…”

Section: Discussionmentioning

confidence: 99%

“…Assuming that only the medial half of the parametrium is removed by vaginal radical trachelectomy, 19,20 and respecting the conclusions of reports on unpredictable parametrial spread, 22Y26 one may question whether this procedure is superior to large cone biopsy with clear resection margins in tumors with a diameter less than 20 mm. 29 Lindsay et al 18 recently reported treatment of 40 patients with stages IA1 to IB1 by repeated LLETZ (large loop excision of the transformation zone) and pelvic lymph node dissection for fertility preservation.…”

Section: Discussionmentioning

confidence: 99%

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Risk of Parametrial Spread in Small Stage I Cervical Carcinoma

Vranes¹,

Milenković²,

Radojević

et al. 2016

International Journal of Gynecological Cancer

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Our data show a risk of parametrial spread of 0.45% for tumors less than 20 mm in diameter, no LVSI, and a depth of invasion within the inner third. Patients wanting fertility preservation might be prepared to take this risk of recurrence. Morbidity after nerve-sparing radical hysterectomy is tolerably low, and for patients in whom fertility preservation is not an issue, this should be considered the standard of care.

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“…However, this approach is not recommended as initial therapy of IB2 tumors (limited to the cervix and having a diameter above 4 cm). [2][3][4][5] For lesions in stage 0 (in situ carcinoma), conization with free margins is sufficient. [2][3][4][5] In stage IA1 (micro-invasion less than 3 mm), the choice will depend on the patient's desire to preserve fertility, and whether there is lymphovascular invasion.…”

Section: Introductionmentioning

confidence: 99%

Cervical cancer: what's new?

Sadalla

Andrade

Genta³

et al. 2015

Rev. Assoc. Med. Bras.

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Financial support: none Cervical cancer is the most common gynecological cancer in Brazil. Among women, it is the second most frequent, second only to breast cancer. It is the fourth leading cause of cancer death in the country, with estimated 15,590 new cases (2014) and 5,430 deaths (2013). In order to update information to improve outcomes, reduce morbidity and optimize the treatment of this cancer, this article will address the advancement of knowledge on cervical cancer. The topics covered include the role of surgery in different stages, treatment of locally advanced carcinomas, fertility preservation, the role of the sentinel lymph node technique, indications and techniques of radiotherapy and chemotherapy, and some special situations.

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The role of trachelectomy in cervical cancer

Cited by 25 publications

References 41 publications

Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single‐institution experience

Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single‐institution experience

Risk of Parametrial Spread in Small Stage I Cervical Carcinoma

Cervical cancer: what's new?

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