The role of tranexamic acid in the management of postpartum haemorrhage

Bouthors, Anne-Sophie; Gilliot, Sixtine; Sentilhes, Loïc; Hennart, Benjamin; Jeanpierre, Emmanuelle; Deneux‐Tharaux, Catherine; Lebuffe, Gilles; Odou, Pascal

doi:10.1016/j.bpa.2022.08.004

Cited by 6 publications

(3 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result, the World Health Organization (WHO) published an updated recommendation on the use of TXA for PPH treatment 4 . Since then, several studies have been performed to evaluate the safety and effectiveness (including cost‐effectiveness) of TXA for the prevention and treatment of PPH, which may occur after vaginal as well as cesarean deliveries 5–14 …”

Section: Introductionmentioning

confidence: 99%

“…then, several studies have been performed to evaluate the safety and effectiveness (including cost-effectiveness) of TXA for the prevention and treatment of PPH, which may occur after vaginal as well as cesarean deliveries. [5][6][7][8][9][10][11][12][13][14] Currently, there is no published study on the awareness of health care professionals regarding the use of TXA for the prevention and management of PPH in Nigeria. Therefore, this study aimed to determine the knowledge and practice of health care providers in Enugu metropolis on the use of TXA for the management of PPH and the barriers to effective adoption and implementation of the new recommendation.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Awareness and use of tranexamic acid in the management of postpartum hemorrhage among health care professionals in Enugu, Nigeria

Onwujekwe,

Mosanya,

Ekwuazi

et al. 2023

Intl J Gynecology & Obste

View full text Add to dashboard Cite

ObjectivesThis study was conducted to determine the knowledge, practice, and barriers regarding the use of tranexamic acid (TXA) for the prevention and treatment of postpartum hemorrhage (PPH) among health care providers in Enugu, Nigeria.MethodsA cross‐sectional study was conducted among health professionals (doctors, pharmacists, and nurses) in two Nigerian tertiary teaching hospitals (one federal and one state). A total of 220 questionnaires were distributed and 207 were returned (response rate: 94%) and analyzed using SPSS for inferential statistics with a level of significance of P < 0.05.ResultsOnly 23.7% of the respondents had good knowledge of TXA use in PPH (P < 0.001), and awareness of the recent World Health Organization (WHO) recommendation on the use of TXA for PPH was low (19.8%, P < 0.001). The majority of the respondents had neither prescribed nor dispensed TXA (30%, P < 0.001). Very few respondents used TXA for all cases of PPH (16.4%, P < 0.001). Barriers against its use include nonawareness of the latest WHO recommendation, preference for other uterotonics, and cost of the drug.ConclusionsThere was poor knowledge of TXA, poor awareness of its recommendation, and low use for PPH among different cadres of health care providers.

show abstract

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Awareness and use of tranexamic acid in the management of postpartum hemorrhage among health care professionals in Enugu, Nigeria

Onwujekwe,

Mosanya,

Ekwuazi

et al. 2023

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…As a consequence, the World Health Organization (WHO) published an updated recommendation on the use of Tranexamic acid (TXA) for Postpartum Haemorrhage treatment 4 . Since then, several studies have been done to evaluate the safety and effectiveness (including cost-effectiveness) of Tranexamic acid for the prevention and treatment of postpartum hemorrhage, which may occur after vaginal as well as cesarean deliveries [5][6][7][8][9][10][11][12][13][14] Currently, there is no published study on the awareness of health care professionals regarding the use of Tranexamic acid for the prevention and management of Postpartum Haemorrhage in Nigeria. Therefore, this study aimed to determine the knowledge and practice of health care providers in Enugu Metropolis on the use of Tranexamic acid for the management of Postpartum Haemorrhage and the barriers to effective adoption and implementation of the new recommendation.…”

Section: Introductionmentioning

confidence: 99%

Awareness and use of Tranexamic Acid in the management of Postpartum Haemorrhage among health care providers in Enugu, Nigeria

Onwujekwe

Mosanya

Ekwuazi

et al. 2023

Preprint

View full text Add to dashboard Cite

Objectives: This study was carried out to determine the knowledge, practice and barriers regarding the use of Tranexamic acid for the prevention and treatment of postpartum hemorrhage among health care providers in Enugu, Nigeria. Methods: A cross sectional study was carried out among health professionals (Doctors, Pharmacists and Nurses) in two Nigerian tertiary teaching hospitals. One is Federal and the other is State. A total of 220 questionnaires were distributed, 207 were collected back (response rate: 94%) and analyzed using SPSS for inferential statistics with level of significance at p < 0.05. Results: Only 23.7% of the respondents had good Knowledge (p<0.001). Good awareness of the recent WHO recommendation on the use of Tranexamic acid for Postpartum Haemorrhage was low (19.8%, <0.001). Majority of the respondents have neither prescribed nor dispensed it (30%; <0.001). Very few respondents use it for all cases of Postpartum Haemorrhage (16.4%; p<0.001). Barriers against its use include non-awareness of the latest WHO recommendation, preference for other utero-tonics and cost of the drug. Conclusions: There was poor knowledge of Tranexamic acid, poor awareness of its recommendation and low use for Postpartum Haemorrhage among different cadres of health care providers.

show abstract

Women with severe postpartum hemorrhage have a decreased endogenous thrombin potential before delivery

Moreuil

Dargaud

Nougier

et al. 2023

Journal of Thrombosis and Haemostasis

View full text Add to dashboard Cite

The role of tranexamic acid in the management of postpartum haemorrhage

Cited by 6 publications

References 79 publications

Awareness and use of tranexamic acid in the management of postpartum hemorrhage among health care professionals in Enugu, Nigeria

Awareness and use of tranexamic acid in the management of postpartum hemorrhage among health care professionals in Enugu, Nigeria

Awareness and use of Tranexamic Acid in the management of Postpartum Haemorrhage among health care providers in Enugu, Nigeria

Women with severe postpartum hemorrhage have a decreased endogenous thrombin potential before delivery

Contact Info

Product

Resources

About