The role of tranexamic acid in obstetric hemorrhage: a narrative review

Abstract

Abnormal postpartum hemorrhage is a common problem, complicating 3-5% of vaginal and operative deliveries. In a majority of cases (98%) uterine atony, retained placenta or genital tract lacerations are responsible for excessive blood loss. However, occasionally, serious coagulopathy may occur early after delivery or in specific circumstances such as with placental abruption. Also, when bleeding is caused by uterine atony, retained placenta or vaginal lacerations, a dilutional coagulopathy may develop. Hence correcting coagulation abnormalities is often required. Crucial to manage postpartum coagulopathy is the use of tranexamic acid to reduce hyperfibrinolysis. In the present narrative review, we will discuss the use of tranexamic acid for the prevention and management of major postpartum hemorrhage by reviewing the available literature.

Awareness and use of tranexamic acid in the management of postpartum hemorrhage among health care professionals in Enugu, Nigeria

“…As a result, the World Health Organization (WHO) published an updated recommendation on the use of TXA for PPH treatment 4 . Since then, several studies have been performed to evaluate the safety and effectiveness (including cost‐effectiveness) of TXA for the prevention and treatment of PPH, which may occur after vaginal as well as cesarean deliveries 5–14 …”

“…then, several studies have been performed to evaluate the safety and effectiveness (including cost-effectiveness) of TXA for the prevention and treatment of PPH, which may occur after vaginal as well as cesarean deliveries. [5][6][7][8][9][10][11][12][13][14] Currently, there is no published study on the awareness of health care professionals regarding the use of TXA for the prevention and management of PPH in Nigeria. Therefore, this study aimed to determine the knowledge and practice of health care providers in Enugu metropolis on the use of TXA for the management of PPH and the barriers to effective adoption and implementation of the new recommendation.…”

Awareness and use of Tranexamic Acid in the management of Postpartum Haemorrhage among health care providers in Enugu, Nigeria

“…As a consequence, the World Health Organization (WHO) published an updated recommendation on the use of Tranexamic acid (TXA) for Postpartum Haemorrhage treatment 4 . Since then, several studies have been done to evaluate the safety and effectiveness (including cost-effectiveness) of Tranexamic acid for the prevention and treatment of postpartum hemorrhage, which may occur after vaginal as well as cesarean deliveries [5][6][7][8][9][10][11][12][13][14] Currently, there is no published study on the awareness of health care professionals regarding the use of Tranexamic acid for the prevention and management of Postpartum Haemorrhage in Nigeria. Therefore, this study aimed to determine the knowledge and practice of health care providers in Enugu Metropolis on the use of Tranexamic acid for the management of Postpartum Haemorrhage and the barriers to effective adoption and implementation of the new recommendation.…”