The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

Соболев, В. В.; Tchepourina, Ekaterina; Korsunskaya, I. M.; Геппе, Н.А.; Chebysheva, S.N.; Соболева, А. Г.; Mezentsev, Alexandre

doi:10.3390/ijms23179708

Cited by 29 publications

(20 citation statements)

References 253 publications

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“…Recently, with the emerging importance of PPARγ in psoriasis, ongoing studies have focused on restoring reduced PPAR-γ levels. 66 In the present study, AuNR-DX and laser combination therapy restored PPAR-γ more effectively than AuNR-DX alone in psoriasis skin (Figure 7b, bottom), mouse skin (Figure 7c,d), keratinocytes (Figure 7e,f), and reduced skin thickness and PASI scores (Figure 7g,h).…”

Section: Enhanced Pharmacological Effects Of Aunr-dx and Nir Laser Co...supporting

confidence: 52%

“…PPAR-γ can be activated by photothermal therapy and is involved in regulating epidermal hyperproliferation and abnormal keratinocyte differentiation, rendering it a potential therapeutic target for psoriasis treatment. Recently, with the emerging importance of PPAR-γ in psoriasis, ongoing studies have focused on restoring reduced PPAR-γ levels . In the present study, AuNR-DX and laser combination therapy restored PPAR-γ more effectively than AuNR-DX alone in psoriasis skin (Figure b, bottom), mouse skin (Figure c,d), keratinocytes (Figure e,f), and reduced skin thickness and PASI scores (Figure g,h).…”

Section: Resultsmentioning

confidence: 99%

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Ameliorated Skin Inflammation through the Synergistic Effect of Gold Nanorod–Dexamethasone and Photothermal Therapy

Kim,

Jeong,

Lee

et al. 2024

ACS Appl. Mater. Interfaces

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Psoriasis, a prevalent chronic inflammatory skin ailment affecting approximately 2–3% of the global population, is characterized by persistent symptoms. Dexamethasone, a primary corticosteroid for treating psoriasis, demonstrates notable efficacy; however, its limited skin permeation results in documented adverse effects. To address this, the presented study employed a novel strategy to conjugate gold nanorod and dexamethasone and evaluate their potential for mitigating psoriatic inflammation using an imiquimod-induced mouse model and human skin cells. Our findings revealed enhanced cutaneous penetration of gold nanorod and dexamethasone conjugates compared with that of dexamethasone, owing to superior skin penetration. Gold nanorod and dexamethasone conjugates demonstrated an optimal pharmacological impact at minimal dosages without toxicity during extended use. To further enhance the effectiveness of gold nanorod and dexamethasone conjugates, 808 nm near-infrared laser irradiation, which reacts to gold, was additionally applied to achieve thermal elevation to expedite drug skin penetration. Supplementary laser irradiation at 808 nm significantly ameliorated psoriatic symptoms following deep gold nanorod and dexamethasone conjugates penetration. This corresponded with restored peroxisome proliferator-activated receptor-γ levels and accelerated dexamethasone release from the gold nanorod and dexamethasone conjugates complex. These findings highlight the potential of gold nanorod and dexamethasone conjugates to enhance drug penetration through dermal layers, thereby aiding psoriasis treatment. Moreover, its compatibility with photothermal therapy offers prospects for novel therapeutic interventions across various inflammatory skin disorders.

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Section: Enhanced Pharmacological Effects Of Aunr-dx and Nir Laser Co...supporting

confidence: 52%

Section: Resultsmentioning

confidence: 99%

Ameliorated Skin Inflammation through the Synergistic Effect of Gold Nanorod–Dexamethasone and Photothermal Therapy

Kim,

Jeong,

Lee

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

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“…Propagated uterine Mø expressed CD36, a scavenger receptor with affinity to oxidized low-density lipoproteins [ 56 ], as well as Lxra and Pparg , transcription factors regulating lipid metabolism [ 57 , 58 ]. StAR is a cholesterol transport protein regulating steroidogenesis in the rate-limiting initial step [ 59 ], and thus uterine Mø may be deeply implicated in cholesterol metabolism.…”

Section: Discussionmentioning

confidence: 99%

Mixed-Culture Propagation of Uterine-Tissue-Resident Macrophages and Their Expression Properties of Steroidogenic Molecules

Ogawa¹,

Tanida²

2023

Biomedicines

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Tissue-resident macrophages (Mø) play tissue/organ-specific roles, and the physiological/pathological implications of uterine Mø in fertility and infertility are not yet fully understood. Herein, we report a simple propagation method for tissue-resident Mø by mixed culture with the respective tissue/organ-residing cells as the niche. We successfully propagated mouse uterine Mø by mixed culture with fibroblastic cells that exhibited properties of endometrial stromal cells. Propagated mouse uterine Mø were CD206- and arginase-1-positive; iNOS- and MHC-II-negative, indicating M2 polarization; and highly phagocytic, similar to endometrial Mø. Furthermore, uterine Mø were observed to express steroidogenic molecules including SRD5A1 and exhibited gap junction formation, likely with endometrial stromal cells. Accordingly, uterine Mø propagated by mixed culture may provide a new tool for studying immune–endocrine interactions related to fertility and infertility, particularly androgen’s intracrine actions in preparing the uterine tissue environment to support implantation and pregnancy as well as in the etiology of endometriosis.

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“…The etiology and pathophysiology of psoriasis bears some similarities with AD, including obesity, microbial dysbiosis and Th17-mediated inflammation ( 89 ). Clinical studies identified anti-psoriatic effects of TZDs ( 90 ), suggesting these medications may help in AD. Nevertheless, the skin microbiome is distinct in psoriasis and characterized by Corynebacteria spp.…”

Section: Atopic Dermatitismentioning

confidence: 99%

Obesity and the microbiome in atopic dermatitis: Therapeutic implications for PPAR-γ agonists

McAleer

2023

Front. Allergy

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Atopic dermatitis (AD) is an inflammatory skin disease characterized by epidermal barrier disruption, Th2 immune responses to skin allergens and microbial dysbiosis within affected lesions. Studies within the past decade have revealed genetic and environmental factors contributing to AD in children. Obesity is a metabolic disorder that often manifests early in life and is associated with reduced bacterial diversity, leading to skin colonization with lipophilic bacteria and intestinal colonization with pro-inflammatory species. These changes impair epithelial barriers and promote Th17 responses, which may worsen the severity of AD symptoms. While few studies have examined the contribution of microbiota in obesity-induced allergies, there is emerging evidence that PPAR-γ may be an effective therapeutic target. This review discusses the microbiome in pediatric AD, treatment with probiotics, how disease is altered by obesity and potential therapeutic effects of PPAR-γ agonists. While healthy skin contains diverse species adapted for specific niches, lesional skin is highly colonized with Staphylococcus aureus which perpetuates the inflammatory reaction. Treatments for AD should help to restore microbial diversity in the skin and intestine, as well as epithelial barrier function. Pre-clinical models have shown that PPAR-γ agonists can suppress Th17 responses, IgE production and mast cell function, while improving the epidermal barrier and microbial homeostasis. Overall, PPAR-γ agonists may be effective in a subset of patients with AD, and future studies should distinguish their metabolic and anti-inflammatory effects in order to inform the best therapies.

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The Role of Transcription Factor PPAR-γ in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells

Cited by 29 publications

References 253 publications

Ameliorated Skin Inflammation through the Synergistic Effect of Gold Nanorod–Dexamethasone and Photothermal Therapy

Ameliorated Skin Inflammation through the Synergistic Effect of Gold Nanorod–Dexamethasone and Photothermal Therapy

Mixed-Culture Propagation of Uterine-Tissue-Resident Macrophages and Their Expression Properties of Steroidogenic Molecules

Obesity and the microbiome in atopic dermatitis: Therapeutic implications for PPAR-γ agonists

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