The Role of Transient Receptor Potential Channels in Metabolic Syndrome

Liu, Daoyan; Zhu, Zhiming; Tepel, Martín

doi:10.1291/hypres.31.1989

Cited by 45 publications

(39 citation statements)

References 53 publications

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“…Finally, vascular smooth muscle cells get recruited, after a phenotypic switch from contractile to proliferative. TRP channels have been implicated in the major steps (endothelial damage/dysfunction, monocyte adhesion/ penetration, and vascular smooth muscle phenotypic switch) leading to atherosclerosis (reviewed in Kwan et al, 2007;Liu et al, 2008;Tano et al, 2012).…”

Section: Transient Receptor Potential Channels In Cardiovascular Dmentioning

confidence: 99%

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Nilius

Szállaśi

2014

Pharmacological Reviews

448

481

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Section: Transient Receptor Potential Channels In Cardiovascular Dmentioning

confidence: 99%

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Nilius

Szállaśi

2014

Pharmacological Reviews

448

481

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“…The prominent BP profile and magnitude was that of atropine ( figure 4.44 a). Infusion of agonists was done 20 minutes after infusing atropine in most studies in which atropine was used to block the muscarinic receptors (Muntzel et al, 1997;Dimo et al, 2003;Delphine Holopherne et al, 2008;Khwanchuea et al, 2008;Lessa et al, 2008;Liu et al, 2008;Rattmann et al, 2008;Shirasaka et al, 2009;De Menezes et al, 2010). violacea were significantly (p < 0.05) higher than those observed with muscarine after pretreatment of animals with atropine.…”

Section: Does T Violacea Act By Blocking the Beta I Adrenoceptors?mentioning

confidence: 99%

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Raji

Mugabo

Obikeze

2012

Journal of Ethnopharmacology

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Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats I. A. RAJITulbaghia violacea Harv. (Alliaceae) is a small bulbous herb which belongs to the family, Alliaceae, most commonly associated with onions and garlic. In South Africa (SA), this herb has been traditionally used in the treatment of various ailments, including fever, colds, asthma, paralysis, hypertension (HTN) and stomach problems. The aim of this study was to evaluate the effect of methanol leaf extracts (MLE) of T. violacea on the blood pressure (BP) and heart rate (HR) in anaesthetized male spontaneously hypertensive rats; and to find out the mechanism(s) by which it acts.The MLE of T. violacea (5 -150 mg/kg), angiotensin I (ang I, 3.1 -100 µg/kg), captopril (10 mg/kg), angiotensin II (ang II, 3.1 -50 µg/kg), losartan (30 mg/kg), phenylephrine T. violacea (60 mg/kg) and captopril (10 mg/kg) were injected intraperitoneally into iii some SHR for 21 days to investigate the chronic effect of these agents on plasma levels of aldosterone. The mean change, the mean of the individual percentage changes and the percentage difference (in mean) observed with each intervention was calculated and statistically analyzed using the Student's t test for significant difference (p < 0.05). The Microsoft Excel software was used for statistical analysis.T. violacea significantly (p < 0.05) reduced the systolic, diastolic, and mean arterial BP;and HR dose-dependently. In a dose-dependent manner, ang I, ang II, phenylephrine significantly (p < 0.05) increased the BP, while propranolol, muscarine and atropine reduced the BP. The increases in BP due to dobutamine were not dose-dependent. In a dose dependent manner, phenylephrine and propranolol reduced the HR, while dobutamine increased the HR. The effect of ang I, ang II, muscarine and atropine on HR were not dose-dependent; with both increases as well as decreases observed with ang I, and II and atropine, while decreases were seen with muscarine. Captopril produced significant (p < 0.05) reduction in BP which were not associated with any change in HR.The co-infusion of ang I with the MLE produced significant (p < 0.05) reduction in BP, which were not associated with significant changes in HR. The co-infusion of ang II with the MLE did not produce any significant changes in BP or HR when compared to the infusion of the standard drug alone. The co-infusion of phenylephrine with the MLE did

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“…TRPC6 knockout mice have shown greatly enhanced expression of TRPC3 and enhanced agonist-induced arterial vasoconstriction, consequently exhibiting increased blood pressure [40]. This find-ing suggested that increased TRPC3 expression relative to that of TRPC6 may predispose mice to hypertension [63]. The expression level of TRPC6 and the Ca 2+ influx currents it mediated have been found to be increased in the mesenteric arteries of deoxycorticosterone acetate-salt hypertensive rats [64].…”

Section: Trp Channel Subtype C Dysfunction Promotes the Development Omentioning

confidence: 99%

Imbalance and dysfunction of transient receptor potential channels contribute to the pathogenesis of hypertension

Liu

Xiong

Zhu

2014

Sci. China Life Sci.

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Intracellular Ca 2+ homeostasis is essential for vascular function and blood pressure regulation. Because of their unique roles in regulating intracellular Ca 2+ concentration and vascular function, a novel class of non-selective cation channels, called transient receptor potential (TRP) channels, have emerged at the frontier of hypertension research. Based on their role in vasculature function regulation, TRP channels can be divided into two functional subtypes: one that participates in vasoconstriction and one that participates in vasodilatation. A functional imbalance of these two subtypes of TRP channels may disturb intracellular calcium ([Ca 2+ ]i) homeostasis, and the consequent vascular dysfunction may contribute to the development of hypertension. The potential of these TRP channels as novel pharmacological targets for the treatment of human hypertension is of great interest. TRP channels, Ca 2+ homeostasis, vascular function, hypertension Citation:Liu DY, Xiong SQ, Zhu ZM. Imbalance and dysfunction of transient receptor potential channels contribute to the pathogenesis of hypertension. Sci China Life Sci, 2014, 57: 818 -825,

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The Role of Transient Receptor Potential Channels in Metabolic Syndrome

Cited by 45 publications

References 53 publications

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats

Imbalance and dysfunction of transient receptor potential channels contribute to the pathogenesis of hypertension

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