The role of transition metals in the pathogenesis of Parkinson's disease

Kienzl, E.; Puchinger, Leopold; Jellinger, K. A.; Linert, Wolfgang; Stachelberger, H.; Jameson, R. F.

doi:10.1016/0022-510x(95)00210-s

Cited by 126 publications

(55 citation statements)

References 70 publications

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“…Our recent data showed that a pure Fe(III) signal can be measured from intact frozen SN tissue using Mö ssbauer spectroscopy (18). These data indicated that iron is directly bound to NM granules in the SN (4,16,19) and that this signal is increased in PD (20). In addition, Mö ssbauer spectroscopy showed that iron binding sites in NM isolated from the human SN are similar to those of human ferritin and hemosiderin (21).…”

Section: Neuromelanin (Nm)mentioning

confidence: 89%

Identification of L-ferritin in Neuromelanin Granules of the Human Substantia Nigra

Tribl

Asan

Arzberger

et al. 2009

Molecular & Cellular Proteomics

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In the pigmented dopaminergic neurons of the human substantia nigra pars compacta the system relevant in iron storage is the polymer neuromelanin (NM). Although in most cells this function is mainly accomplished by ferritin, this protein complex appears not to be expressed in NM-containing neurons. Nevertheless the conceivable presence of iron-storing proteins as part of the NM granules has recently been discussed on the basis of Mö ssbauer spectroscopy and synchrotron x-ray microspectroscopy. Intriguingly by combining subcellular fractionation of NM granules, peptide sequencing via tandem mass spectrometry, and the additional confirmation by multiple reaction monitoring and immunogold labeling for electron microscopy, L-ferritin could now be unambiguously identified and localized in NM granules for the first time. This finding not only supports direct evidence for a regulatory role of L-ferritin in neuroectodermal cell pigmentation but also integrates a new player within a complicated network governing iron homeostasis in the dopamine neurons of the human substantia nigra. Thus our finding entails far reaching implications especially when considering etiopathogenetic aspects of Parkinson disease.

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Section: Neuromelanin (Nm)mentioning

confidence: 89%

Identification of L-ferritin in Neuromelanin Granules of the Human Substantia Nigra

Tribl

Asan

Arzberger

et al. 2009

Molecular & Cellular Proteomics

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“…1 But its deficiency or overload can induce serious disorders and infectious diseases such as anemia, 2 hemochromatosis, 3 malaria, 4 Parkinson, 5 Alzheimer. 6 Many techniques for detecting Fe 3+ have been reported, including atomic absorption spectrometry, 7,8 voltammetry, 9 fluorometric and colorimetric method.…”

Section: Introductionmentioning

confidence: 99%

A new Rhodamine B derivative RBMAB as a highly selective and sensitive chemosensor for Fe3+ with low detection limit

Shen¹,

Wang²,

Chen³

et al. 2016

Quim. Nova

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A new Rhodamine B derivative RBMAB, namely 3-amino-N-(2-(3',6'-bis (diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl) ethyl)benzamide, was designed, synthesized and structurally characterized to develop a chemosensor. The studies show that RBMAB exhibits high selectivity toward Fe 3+ among many other metal cations in an ethanol-H 2 O (3:2, v/v, PBS buffer, 1.2 mmol L -1 , pH 7.2) solution. It has a low detection limit of 0.021μm. Fluorescence microscopy experiments further demonstrate that RBMAB can be used as a fluorescent probe to detect Fe 3+ in living cells.

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“…6-Hydroxydopamine (6-OHDA) is a selective toxin for neuronal cells and can be produced from dopamine by nonenzymatic hydroxylation (Kienzl et al, 1995). It has been shown to cause apoptotic actions of dopaminergic cells in experimental models .…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of luteolin against apoptosis induced by 6-hydroxydopamine on rat pheochromocytoma PC12 cells

Guo¹,

Fan²,

Yu³

et al. 2012

Pharmaceutical Biology

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The role of transition metals in the pathogenesis of Parkinson's disease

Cited by 126 publications

References 70 publications

Identification of L-ferritin in Neuromelanin Granules of the Human Substantia Nigra

Identification of L-ferritin in Neuromelanin Granules of the Human Substantia Nigra

A new Rhodamine B derivative RBMAB as a highly selective and sensitive chemosensor for Fe3+ with low detection limit

Neuroprotective effects of luteolin against apoptosis induced by 6-hydroxydopamine on rat pheochromocytoma PC12 cells

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