The role of trapidil on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury

Atıcı, Aytuğ; Bozlu, Gülçin; Turhan, Ali Haydar; Polat, Ayşe; Naycı, Ali; Okuyaz, Çetin; Taşkınlar, Hakan

doi:10.1016/j.earlhumdev.2007.06.005

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Several studies demonstrate its beneficial effects in various forms of tissue injury. 6 Trapidil is an antiplatelet-derived growth factor and vasodilator, which effect is achieved by competitive inhibition of phosphodiesterase. 7 It decreases platelet aggregation, which is attributed to its ability to increase prostaglandin synthesis, 8 inhibits platelet activation by reducing thromboxane synthetase, 9 and inhibits the proliferative effects of platelet-derived growth factor (PDGF) on vascular smooth muscle cells.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of trapidil andl-arginine against renal and hepatic toxicity induced by cyclosporine in rats

Salem

Maarouf

et al. 2010

Renal Failure

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(2010) Protective effect of trapidil and l-arginine against renal and hepatic toxicity induced by cyclosporine in rats, Renal Failure, 32:8,[959][960][961][962][963][964][965][966][967][968] DOI: 10.3109 CsA induced renal and hepatic dysfunction, which was confirmed by laboratory and histopathological examination. Administration of trapidil diminished the renal and liver injury and significantly attenuated the levels of serum creatinine, urea, aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin1b (IL-1b), tumor necrosis factor alpha (TNF-a), monocyte chemoattractant protein-1 (MCP-1), and oxidative stress, while it significantly elevated the level of serum nitric oxide and the activity of antioxidative stress. L-Arginine gave the same trend as trapidil, but trapidil effect was more pronounced. Coadministration of trapidil + L-arginine significantly ameliorated the toxic effect of CsA, but did not differ significantly from the effect of trapidil alone. Conclusions: Treatment with trapidil or L-arginine diminished the renal and hepatic CsA-induced toxicity. However, the effect of trapidil was more pronounced. Therefore, treatment with trapidil alone may be the most economic and effective as a potential therapeutic agent in CsA injury.

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Section: Introductionmentioning

confidence: 99%

Protective effect of trapidil andl-arginine against renal and hepatic toxicity induced by cyclosporine in rats

Salem

Maarouf

et al. 2010

Renal Failure

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“…These studies indicated that the acute effects of HIE may be managed with agents that reduce apoptosis (23,24). In the present study, a significant increase was observed in caspase-3 levels in the hypoxia group compared with those in the control at 4 and 24 h following HI induction.…”

Section: Discussionmentioning

confidence: 99%

Role of immunoglobulin in neuronal apoptosis in a neonatal rat model of hypoxic ischemic brain injury

Kalay¹,

Öztekin²,

Tezel³

et al. 2014

Experimental and Therapeutic Medicine

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The objective of the present study was to evaluate the neuroprotective effects of immunoglobulin (Ig) in a neonatal hypoxic ischemic (HI) rat model. Seven-day-old rat pups were randomly assigned to control, hypoxia and hypoxia + Ig groups. The rats in the hypoxia +Ig group were intraperitoneally administered 1 g/kg Ig once, immediately after hypoxia. Saline was administered to the rats in the hypoxia group at the same time point. Eight rats from each of the Ig + hypoxia and hypoxia groups were sacrificed by decapitation 4 and 24 h following the administration of Ig or saline. The rats of the control group were sacrificed at the 4 h time-point. Caspase-3 activity, as well as IL-1β, IL-6 and TNF-α mRNA expression levels, were studied in the left ischemic hemispheres. Induction of cerebral ischemia increased the TNF-α, IL-6 and IL-1β mRNA expression levels significantly at 4 and 24 h in the left ischemic hemispheres in the hypoxia group compared with those in the control group. The systemic administration of Ig following HI encephalopathy significantly reduced the TNF-α, IL-6 and IL-1β mRNA expression levels in the ischemic tissue in the Ig + hypoxia group compared with those in the hypoxia group. In the hypoxia group, caspase-3 activity in the left half of the brain was found to be significantly increased compared with that in the control group. Caspase-3 activity in the Ig + hypoxia group was significantly lower than that in the hypoxia group. The observations of the present study indicate that Ig administration may be an efficient treatment approach for reducing cerebral apoptosis associated with hypoxic ischemia.

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“…Hipoksinin bafllang›çta oluflturdu¤u hasar›n yan› s›ra; reperfüzyonun, glutamat ve nitrik oksit nörotoksisitesinin, serbest radikal oluflumunun ve kalsiyum birikiminin etkisiyle geliflen apopitoz beyinde geri dönüflümsüz hasara yol açar (3)(4)(5). Bu döneme geçmeden verilecek tedaviler ile hasar›n önlenmesi ya da azalt›lmas› mümkün olabilir (23,24). PAF'›n H‹BH oluflumunda önemli bir arac› olmas›, PAF antagonistlerinin tedavide etkili olabilece¤ini düflündürmektedir.…”

Section: Tart›flmaunclassified

Hipoksik iskemik beyin hasarı oluşturulan yenidoğan sıçanlarda ABT-491 uygulamasının görsel uyarılma potansiyelleri üzerine etkileri

Atıcı¹

2010

tpa

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H Hi ip po ok ks si ik k i is sk ke em mi ik k b be ey yi in n h ha as sa ar r› › o ol lu ufl flt tu ur ru ul la an n y ye en ni id do o¤ ¤a an n s s› ›ç ça an nl la ar rd da a A AB BT T--4 49 91 1 u uy yg gu ul la am ma as s› ›n n› ›n n g gö ör rs se el l u uy ya ar r› ›l lm ma a p po ot ta an ns si iy ye el ll le er ri i ü üz ze er ri in ne e e et tk ki il le er ri i T Th he e e ef ff fe ec ct ts s o of f A AB BT T--4 49 91 1 a ad dm mi in ni is st tr ra at ti io on n o on n v vi is su ua al l e ev vo ok ke ed d p po ot te en nt ti ia al ls s i in n r ra at t m mo od de el l o of f h hy yp po ox xi ic c i is sc ch he em mi ic c b br ra ai in n i in nj ju ur ry y S Su um mm ma ar ry yAim: In the present study, we aimed to investigate the effects of ABT-491 on visual evoked potentials (VEP) in rat model of hypoxic ischemic brain injury (HIBI). Material and Method:Fifty-seven male Wistar newborn rats were used in this study. Animals were divided into three groups randomly. HIBI was formed on postnatal seventh day according to modified Levine-Rice model in 1st (n=18) and 2nd (n=20) groups. Third group (n=19) served as sham group. After HIBI, ABT-491 was applied intraperitoneally to rats in the 1st group (ABT group) and saline was administered to the rats in the 2nd group (saline group). On postnatal 16th weeks, VEPs were recorded from Ag-AgCl disc electrode placed on the occipital region. Results:The latencies of P3 wave were shorter in the ABT group than the saline group (p<0.05). Peak-to-peak amplitudes of P2-N2 and N2-P3 were smaller in the ABT and saline groups compared to the sham group (for all pairwise comparisons p<0.001).Conclusions:It was concluded that HIBI caused a decrement in amplitudes of VEP responses and this change could not be ameliorated with ABT-491. However, shortening in latencies of P3 wave could be ameliorated with ABT-491 treatment after HIBI was formed. (Turk Arch Ped 2010; 45: 319-23)

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The role of trapidil on neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury

Cited by 5 publications

References 22 publications

Protective effect of trapidil andl-arginine against renal and hepatic toxicity induced by cyclosporine in rats

Protective effect of trapidil andl-arginine against renal and hepatic toxicity induced by cyclosporine in rats

Role of immunoglobulin in neuronal apoptosis in a neonatal rat model of hypoxic ischemic brain injury

Hipoksik iskemik beyin hasarı oluşturulan yenidoğan sıçanlarda ABT-491 uygulamasının görsel uyarılma potansiyelleri üzerine etkileri

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