The Role of Triple Therapy, Age, Gender and Smoking on the Genotoxic Effects of <i>Helicobacter Pylori</i> Infection

Gulten, T; Tokyay, N; Demiray, Mutlu; Gülten, Macit; Ercan, I.; Evke, Elif; Şardaş, Semra; Karakaya, Asuman

doi:10.1177/147323000203000403

Cited by 6 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, H pylori-positive CAG patients had a higher SCE frequency than H pylori-negative CAG patients. This finding is consistent with the study of Gulten et al [61] . Similarly, H pylori-positive GC patients had a higher SCE frequency than H pylori-negative GC patients.…”

Section: Discussionsupporting

confidence: 94%

“…However, the mean frequencies of both groups were significantly higher than that of the control group [60] . Furthermore, Gulten et al [61] reported increased SCE frequencies in a group of gastritis patients infected with H pylori.…”

Section: Discussionmentioning

confidence: 98%

“…Our results confirm and extend these findings to patients with CAG. Many investigators have demonstrated genomic instability and abnormalities in patients with CAG and GC [60,61,64,65] . Our analysis suggests that chromosomal instability (DNA) is present at very early stages of neoplastic progression in CAG and GC patients.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Alteration of sister chromatid exchange frequencies in gastric cancer and chronic atrophic gastritis patients with and without H pylori infection

Karaman

Binici²,

Kabalar³

et al. 2008

WJG

View full text Add to dashboard Cite

AIM:To determine, by counting sister chromatid exchange (SCE) frequencies, whether genetic impairment and DNA damage have an effect on the pathogenesis of gastric cancer (GC). METHODS:Analysis of SCE is a cytogenetic technique used to show DNA damage as a result of an exchange of DNA fragments between sister chromatids. We analyzed SCE frequency in 24 patients with GC, 26 patients with chronic atrophic gastritis (CAG), and 15 normal controls. The presence of H pylori was confirmed by urease test, toluidine-blue stain and hematoxylin-eosin stain.RESULTS: SCE was significantly increased in H pylorinegative GC patients, and in H pylori -negative CAG patients compared with controls (7.41 ± 1.36 and 6.92 ± 1.20, respectively, vs 5.54 ± 0.8, P < 0.001). There was no difference in the SCE frequency between H pylorinegative GC patients and H pylori -negative CAG patients (P > 0.05). On other hand, the SCE frequencies in H pylori -positive GC patients were higher than those in H pylori -positive CAG patients (9.20 ± 0.94 vs 7.93 ± 0.81, P < 0.01). Furthermore, H pylori -positive GC patients had a higher SCE frequency than H pylorinegative GC patients (9.20 ± 0.94 vs 7.41 ± 1.36, P < 0.001). Similarly, a significant difference was detected between H pylori -positive CAG patients and H pylori -negative CAG patients (7.93 ± 0.81 vs 6.92 ± 1.20, P < 0.05). CONCLUSION:We suggest the increased SCE in patients reflects a genomic instability that may be operative in gastric carcinogenesis.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Alteration of sister chromatid exchange frequencies in gastric cancer and chronic atrophic gastritis patients with and without H pylori infection

Karaman

Binici²,

Kabalar³

et al. 2008

WJG

View full text Add to dashboard Cite

show abstract

“…Karaman et al (2008) described that gastric cancer and patients with H.pylori infection (9.20 ± 0.94/cell) had a higher SCE frequency than those without H.pylori (7.41 ± 1.36/cell). In gastritis, H.pylori eradication therapy (5.84 ± 1.52/cell) decreased the SCE frequency compared to that of the presence of H.pylori infection (8.94 ± 2.01/cell) (Gulten et al, 2002). In our present study, our results showed no association between the SCE frequency and not only gender, the tumor grade and Lauren's classification, but also H.pylori infection in gastric cancer.…”

Section: Discussioncontrasting

confidence: 76%

The Frequency and Clinical Significance of Sister Chromatid Exchange in the Lymphocyte of Gastric Cancer Patient Exposed to Hypoxia

Kim

Lee²,

Kim³

et al. 2012

CCO

View full text Add to dashboard Cite

The frequency of sister chromatid exchange (SCE) in patients with gastric cancer is significantly higher than that in normal individuals; however, their characteristics have not been studied. In present study, we analyzed the correlation between the cytogenetic instability of gastric cancer patients’ peripheral lymphocytes with or without hypoxia and the characteristics of gastric cancer patients. The primary lymphocyte cultures obtained from blood samples of 40 healthy donors and 69 patients with gastric cancer were examined using SCE. The average of SCE frequency in gastric cancer was 5.91 ± 2.03/cell and the SCE phenotype was not associated with gender, tumor grade, Lauren classification, and H.pylori infection. Hypoxia increased the SCE frequency as compared with normoxia, in both the control and gastric cancer lymphocyte cultures (P < 0.001). The hypoxic effect in gastric cancer was not associated with gender, tumor grade, Lauren classification, and H.pylori infection. In conclusion, hypoxia did not facilitate an increase of SCE in the lymphocytes of the gastric cancer.

show abstract

“…Recommendations from the recent Maastricht III Consensus Report suggest H. pylori therapy initiation in patients with gastric and peptic ulcer disease, patients with atrophic gastritis, and first-degree relatives of patients with history of gastric cancer. In a study investigating whether risk of gastric cancer is modified in patients with gastritis, however, it was found that male gender and increasing age appeared to be associated with a reduction in the effectiveness of H. pylori treatment (Gulten et al, 2002).…”

Section: H Pylori Treatmentmentioning

confidence: 98%

Care of Older Adult Populations Diagnosed With Helicobacter pylori

Fromm¹

2009

Gastroenterology Nursing

View full text Add to dashboard Cite

Helicobacter pylori has been linked to development of peptic ulcers and increases the risk of developing gastric carcinoma. Currently, about half of the world's population is infected with H. pylori, many of whom are older adults. Older adult populations often have multiple comorbidities that may mask dyspeptic signs and symptoms. The role of H. pylori and infective signs vary by age, and the confusing symptoms in older adult populations may delay detection and treatment of H. pylori. In addition, time of detection and appropriate treatment is paramount to prevent gastric pathology. Clinicians need to recognize and understand the importance of risk factors, screening, detection, and treatment of H. pylori, particularly in older adults. Earlier detection and more aggressive, proactive clinical recognition of dyspeptic signs and symptoms may lead to earlier screening and diagnosis of H. pylori in older adult populations and help decrease the frequency of gastric metaplasia.

show abstract

The Role of Triple Therapy, Age, Gender and Smoking on the Genotoxic Effects of Helicobacter Pylori Infection

Cited by 6 publications

References 12 publications

Alteration of sister chromatid exchange frequencies in gastric cancer and chronic atrophic gastritis patients with and without H pylori infection

Alteration of sister chromatid exchange frequencies in gastric cancer and chronic atrophic gastritis patients with and without H pylori infection

The Frequency and Clinical Significance of Sister Chromatid Exchange in the Lymphocyte of Gastric Cancer Patient Exposed to Hypoxia

Care of Older Adult Populations Diagnosed With Helicobacter pylori

Contact Info

Product

Resources

About