The Role of Tumor Associated Macrophages in Hepatocellular Carcinoma

Huang, Yu; Ge, Weifeng; Zhou, Jiarong; Gao, Bo; Qian, Xiaohui; Wang, Weilin

doi:10.7150/jca.51346

Cited by 72 publications

(63 citation statements)

References 118 publications

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“…The microenvironment of solid tumors is characterized by a reactive stroma with an abundance of inflammatory mediators and leukocytes, dysregulated vessels, and proteolytic enzymes. TAMs, major players in the connection between inflammation and cancer, summarize a number of functions (e.g., promotion of tumor cell proliferation and angiogenesis, incessant matrix turnover, repression of adaptive immunity), which ultimately have an important impact on disease progression [ 4 , 6 ]. Thus, together with other myeloid-related cells present at the tumor site (Tie2 macrophages and MDSCs), TAMs represent an attractive target of novel biological therapies of tumors [ 4 , 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…TAMs, major players in the connection between inflammation and cancer, summarize a number of functions (e.g., promotion of tumor cell proliferation and angiogenesis, incessant matrix turnover, repression of adaptive immunity), which ultimately have an important impact on disease progression [ 4 , 6 ]. Thus, together with other myeloid-related cells present at the tumor site (Tie2 macrophages and MDSCs), TAMs represent an attractive target of novel biological therapies of tumors [ 4 , 6 ]. However, the underlying mechanism of TAM polarization in metastasis still remains undefined.…”

Section: Discussionmentioning

confidence: 99%

“…The poor outcome of patients with HCC is correlated with metastasis based on a unique immune response signature of the liver microenvironment [ 2 , 3 ]. Accumulating evidence has demonstrated that in many solid tumor microenvironments, tumor-associated macrophages (TAMs) play a key role in cancer development [ 4 , 5 , 6 , 7 ]. The findings of numerous, recent experimental studies indicate that the polarization of TAMs has an important role in tumorigenesis, including metastasis [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Role of the Inflammatory Response of RAW 264.7 Cells in the Metastasis of Novel Cancer Stem-Like Cells

et al. 2021

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Background and objectives: Tumor progression and the immune response are intricately linked. Additionally, the presence of macrophages in the microenvironment is essential for carcinogenesis, but regulation of the polarization of M1- and M2-like macrophages and their role in metastasis remain unclear. Based on previous studies, both reactive oxygen species (ROS) and the endoplasmic reticulum (ER) are emerging as key players in macrophage polarization. While it is known that cancers alter macrophage inflammatory responses to promote tumor progression, there is limited knowledge regarding how they affect the macrophage-dependent innate host defense. Materials and methods: We detected the levels of ROS, the ability of chemotaxis, the expressions of markers of M1-/M2-like macrophages in RAW264.7 in presence of T2- and T2C-conditioned medium. Results: The results of this study indicated that ROS levels were decreased in RAW 264.7 cells when cultured with T2C-conditioned medium, while there was an improvement in chemotaxis abilities. We also found that the M2-like macrophages were characterized by an elongated shape in RAW 264.7 cells cultured in T2C-conditioned medium, which had increased CD206 expression but decreased expression of CD86 and inducible nitric oxide synthase. Suppression of ER stress shifted polarized M1-like macrophages toward an M2-like phenotype in RAW 264.7 cells cultured in T2C-conditioned medium. Conclusions: Taken together, we conclude that the polarization of macrophages is associated with the alteration of cell shape, ROS accumulation, and ER stress.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of the Inflammatory Response of RAW 264.7 Cells in the Metastasis of Novel Cancer Stem-Like Cells

et al. 2021

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“…This is achieved by directly suppressing immunosurveillance by inhibiting the anti-tumor activity of infiltrating immune cells while facilitating the recruitment and sustaining the function of pro-tumoral immune cells that enhance metastatic progression. The extensive role of the TGF-β signaling pathway in regulating immune cell functions has been reviewed in detail elsewhere [149][150][151][152].…”

Section: Tgf-β and Tumor Microenvironmentmentioning

confidence: 99%

“…Here, we provide an overview of the main activities of TGF-β on macrophages, neutrophils, myeloid-derived suppressor cells (MDSCs), T cells, and cancer-associated fibroblasts that enhance tumor development and progression with some evidence for GI tumors. The contribution of the crosstalk between tumor cells and TAMs in GI tumor development and immune evasion has been reviewed in detail elsewhere [149][150][151][152].…”

Section: Tgf-β and Tumor Microenvironmentmentioning

confidence: 99%

The Multifaceted Role of TGF-β in Gastrointestinal Tumors

Sabbadini

Bertolini

Matteis

et al. 2021

Cancers

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Transforming growth factor-beta (TGF-β) is a secreted cytokine that signals via serine/threonine kinase receptors and SMAD effectors. Although TGF-β acts as a tumor suppressor during the early stages of tumorigenesis, it supports tumor progression in advanced stages. Indeed, TGF-β can modulate the tumor microenvironment by modifying the extracellular matrix and by sustaining a paracrine interaction between neighboring cells. Due to its critical role in cancer development and progression, a wide range of molecules targeting the TGF-β signaling pathway are currently under active clinical development in different diseases. Here, we focused on the role of TGF-β in modulating different pathological processes with a particular emphasis on gastrointestinal tumors.

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The role of tumor‐associated macrophages in hepatocellular carcinoma progression: A narrative review

Zhang,

Yu,

Zhao

et al. 2023

Cancer Medicine

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, with complex etiology and mechanism, and a high mortality rate. Tumor‐associated macrophages (TAMs) are an important part of the HCC tumor microenvironment. Studies in recent years have shown that TAMs are involved in multiple stages of HCC and are related to treatment and prognosis in HCC. The specific mechanisms between TAMs and HCC are gradually being revealed. This paper reviews recent advances in the mechanisms associated with TAMs in HCC, concentrating on an overview of effects of TAMs on drug resistance in HCC and the signaling pathways linked with HCC, providing clues for the treatment and prognosis determination of HCC.

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The Role of Tumor Associated Macrophages in Hepatocellular Carcinoma

Cited by 72 publications

References 118 publications

Role of the Inflammatory Response of RAW 264.7 Cells in the Metastasis of Novel Cancer Stem-Like Cells

Role of the Inflammatory Response of RAW 264.7 Cells in the Metastasis of Novel Cancer Stem-Like Cells

The Multifaceted Role of TGF-β in Gastrointestinal Tumors

The role of tumor‐associated macrophages in hepatocellular carcinoma progression: A narrative review

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