The Role of Tumor Microenvironment in Mycosis Fungoides and Sézary Syndrome

Liu, Zhaorui; Wu, Xuesong; Hwang, Samuel T; Liu, Jie

doi:10.5021/ad.2021.33.6.487

Cited by 13 publications

(11 citation statements)

References 72 publications

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“…While the exact molecular events underlying CTCL progression remain poorly understood, prior research has reported that the tumor microenvironment (TME) plays a pivotal role [ 23 , 31 , 32 , 33 ]. During early stages, CD8+ resident memory T cells (T RM ) harboring cytotoxic capacity and a skewed T helper (Th) 1 immune response are predominantly observed in the skin microenvironment, while the number of neoplastic T cells remains relatively low [ 34 , 35 ] ( Figure 1 b).…”

Section: The Tumor Microenvironment (Tme) and Immune Response In Ctclmentioning

confidence: 99%

Spatially Guided and Single Cell Tools to Map the Microenvironment in Cutaneous T-Cell Lymphoma

Kalliara

Belfrage

Gullberg

et al. 2023

Cancers

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Mycosis fungoides (MF) and Sézary syndrome (SS) are two closely related clinical variants of cutaneous T-cell lymphomas (CTCL). Previously demonstrated large patient-to-patient and intra-patient disease heterogeneity underpins the importance of personalized medicine in CTCL. Advanced stages of CTCL are characterized by dismal prognosis, and the early identification of patients who will progress remains a clinical unmet need. While the exact molecular events underlying disease progression are poorly resolved, the tumor microenvironment (TME) has emerged as an important driver. In particular, the Th1-to-Th2 shift in the immune response is now commonly identified across advanced-stage CTCL patients. Herein, we summarize the role of the TME in CTCL evolution and the latest studies in deciphering inter- and intra-patient heterogeneity. We introduce spatially resolved omics as a promising technology to advance immune-oncology efforts in CTCL. We propose the combined implementation of spatially guided and single-cell omics technologies in paired skin and blood samples. Such an approach will mediate in-depth profiling of phenotypic and molecular changes in reactive immune subpopulations and malignant T cells preceding the Th1-to-Th2 shift and reveal mechanisms underlying disease progression from skin-limited to systemic disease that collectively will lead to the discovery of novel biomarkers to improve patient prognostication and the design of personalized treatment strategies.

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Section: The Tumor Microenvironment (Tme) and Immune Response In Ctclmentioning

confidence: 99%

Spatially Guided and Single Cell Tools to Map the Microenvironment in Cutaneous T-Cell Lymphoma

Kalliara

Belfrage

Gullberg

et al. 2023

Cancers

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“…T-cells from patients with MF express cutaneous lymphocyte antigen and the chemokine receptors of CCR-4 and CCR-10, whereas CCR-7 is seen in the tumor stage of MF. The patients' immune response changes throughout the disease progression as the early stage of MF is marked by an elevation in the TH1 cytokines and advanced stage is marked by TH2 (Liu et al, 2021). Risk factors in the development of MF include underlying malignant hemopathies and immunosuppressive states, which further support the microenvironment that allows for the proliferation of MF.…”

Section: Pathogenesismentioning

confidence: 99%

Mycosis Fungoides in Skin of Color

Rager

Lake

2022

Journal of the Dermatology Nurses' Association

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Mycosis fungoides is the most common primary cutaneous T-cell lymphoma. Although mycosis fungoides affects patients of all skin tones, mycosis fungoides has a higher incidence in patients with skin of color. Patients with skin of color who are diagnosed with mycosis fungoides have worse outcomes and poor prognosis compared with patients with lighter skin tones. Mycosis fungoides is difficult to diagnose in patients with skin of color as rare subtypes or clinical presentations are commonly seen in these populations. Increased awareness of the presentation of mycosis fungoides in skin of color and early detection could address the higher rates of morbidity and mortality in these populations.

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“…5,6 Progressive immune dysfunction is associated with tumour cell growth, with a shift from antitumorigenic tumour-associated macrophages to pro-tumorigenic tumour-associated macrophages. 7 It was emphasised that optimal therapies for MF and SS are likely to be those targeting malignant cells and/or restoring the Type 1 helper T cell/Type 2 helper T cell balance. [5][6][7] Cellular senescence plays a role in posttherapeutic outcomes in CTCL and other malignancies.…”

Section: Martine Bagot and Manuel Serranomentioning

confidence: 99%

“…7 It was emphasised that optimal therapies for MF and SS are likely to be those targeting malignant cells and/or restoring the Type 1 helper T cell/Type 2 helper T cell balance. [5][6][7] Cellular senescence plays a role in posttherapeutic outcomes in CTCL and other malignancies. Research data presented by Serrano (Institute for Research in Biomedicine, Barcelona, Spain) during the symposium explained that senescent cells are often able to avoid cancer immunotherapy by secreting immunosuppressive factors, and that, upon cessation of therapy, this environment permits the regrowth of tumour cells.…”

Section: Martine Bagot and Manuel Serranomentioning

confidence: 99%

An Overview of the EORTC-CLTG 2022 Congress

Humphry¹

2022

EMJ Oncol

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This year's European Organisation for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Tumours Group (CLTG) Annual Meeting was held in Madrid, Spain. Presentations covered a broad range of topics in the field of cutaneous lymphomas, from molecular mechanisms, through diagnostics and prediction of prognosis, to skin-directed and targeted therapies, combination therapies, and patient-reported outcomes.There was an overall feeling at the EORTC-CLTG meeting that further research is needed to better define the molecular basis for the different forms of cutaneous T cell lymphoma (CTCL), which will facilitate the development of novel treatments and therapeutic drug combinations. However, it was clear that significant progress had been made in understanding the biology behind CTCL, and that a broad range of therapies are available that provide symptomatic control in many patients.

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The Role of Tumor Microenvironment in Mycosis Fungoides and Sézary Syndrome

Cited by 13 publications

References 72 publications

Spatially Guided and Single Cell Tools to Map the Microenvironment in Cutaneous T-Cell Lymphoma

Spatially Guided and Single Cell Tools to Map the Microenvironment in Cutaneous T-Cell Lymphoma

Mycosis Fungoides in Skin of Color

An Overview of the EORTC-CLTG 2022 Congress

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