2006
DOI: 10.1016/j.pain.2006.03.011
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The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat

Abstract: Accumulating evidence has demonstrated that tumor necrosis factor-alpha (TNF-alpha) plays an important role in neuropathic pain. Recently, it has been shown that Lumbar 5 ventral root transection (L5 VRT) induces persistent mechanical allodynia and thermal hyperalgesia in bilateral hind paws. In the present study, the role of TNF-alpha in the L5 VRT model was investigated. We found that immunoreactivity (IR) of TNF-alpha and TNF receptor 1 (TNFR1) in ipsilateral (but not in contralateral) L4 and L5 dorsal root… Show more

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Cited by 210 publications
(209 citation statements)
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“…administration of 2 0 ,3 0 -dideoxycytidine (a nucleoside reverse transcriptase inhibitor) upregulates CXCL12 and CXCR4 in the lumbar DRG and spinal cord, and both are regulated by TNF-a [18]. Our previous study demonstrated that peripheral nerve injury upregulates TNF-a in the DRG and spinal neurons and astrocytes, while increased TNFR1 (one of the receptors for TNF-a) is primarily localized to neurons [29]. In the present study, the SNI-induced increase in CXCL12 was localized to spinal neurons.…”
Section: Tnf-a Might Mediate the Increased Cxcl12 Expression In The Dmentioning
confidence: 98%
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“…administration of 2 0 ,3 0 -dideoxycytidine (a nucleoside reverse transcriptase inhibitor) upregulates CXCL12 and CXCR4 in the lumbar DRG and spinal cord, and both are regulated by TNF-a [18]. Our previous study demonstrated that peripheral nerve injury upregulates TNF-a in the DRG and spinal neurons and astrocytes, while increased TNFR1 (one of the receptors for TNF-a) is primarily localized to neurons [29]. In the present study, the SNI-induced increase in CXCL12 was localized to spinal neurons.…”
Section: Tnf-a Might Mediate the Increased Cxcl12 Expression In The Dmentioning
confidence: 98%
“…To test the specificity of the anti-CXCL12 and anti-CXCR4 antibodies, we used a pre-incubation method [28,29]. The anti-CXCL12 antibody was pre-incubated with 10 lg/mL CXCL12 (5-fold that of the anti-CXCL12 antibody) at 4°C for 1 h, and then the pre-incubated antibody was applied to spinal cord sections to detect the immunoreactivity (IR) of CXCL12 by immunohistochemistry.…”
Section: Immunohistochemistrymentioning
confidence: 99%
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“…The pain-related behavioral tests were performed according to our previously described methods [26,27] . All rats were acclimated to the testing environment for at least (the constant 13 refers to the cutoff time).…”
Section: Nociception Testsmentioning
confidence: 99%
“…Immunohistochemistry was done following our previous procedures [26,27] . Briefl y, after 5 or 7 days of i.t.…”
Section: Immunohistochemistrymentioning
confidence: 99%