The role of ubiquinones in the regulation of lipid metabolism in rat thymocytes

Новоселова, Е. Г.

doi:10.1016/0014-5793(89)80661-1

Cited by 6 publications

(1 citation statement)

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“…A significant decrease in cholesterol synthesis and a subsequent drop in the cholesterol concentration of the cellular membranes were observed in rats fed a diet supplemented with ubiquinone Q 9 . Additionally, the inhibition of cholesterol synthesis in lymphocytes cultivated in vitro with coenzyme Q 9 was demonstrated [29, 30]. Interestingly, our data indicated that the preintervention with dietary antioxidants decreased the magnitude of the inflammatory response, but diet did not amplify the effect of IKK Inhibitor XII.…”

Section: Discussionmentioning

confidence: 72%

Anti-Inflammatory Effects of IKK Inhibitor XII, Thymulin, and Fat-Soluble Antioxidants in LPS-Treated Mice

Новоселова

Хренов

Глушкова

et al. 2014

Mediators of Inflammation

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The present study was designed to compare the anti-inflammatory effects of several agents applied in vivo, namely, a synthetic inhibitor of the NF-κB cascade, fat-soluble antioxidants, and the thymic peptide thymulin. Cytokine response in LPS-treated mice was analysed in tandem with the following parameters: the synthesis of inducible forms of the heat shock proteins HSP72 and HSP90α; activity of the NF-κB and SAPK/JNK signalling pathways; and TLR4 expression. Inflammation-bearing Balb/c male mice were pretreated with an inhibitor of IKK-α/β kinases (IKK Inhibitor XII); with thymulin; with dietary coenzyme Q9, α-tocopherol, and β-carotene; or with combinations of the inhibitor and peptide or antioxidants. Comparable anti-inflammatory effects were observed in inflammation-bearing mice treated separately with thymulin or with dietary antioxidants administered daily for two weeks before LPS treatment. When LPS-injected mice were treated with the inhibitor and antioxidants together, neither plasma cytokines, signal proteins, nor heat shock proteins recovered more efficiently than when mice were treated with these agents separately. In contrast to antioxidant diet, the thymulin was shown to increase the effect of IKK Inhibitor XII in preventing IKK activation in LPS-treated mice.

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Section: Discussionmentioning

confidence: 72%