The Role of Ultrasound and Laboratory Methods of Studying Comorbid Conditions in Parkinson's Disease

Abstract

To study the effect of certain parameters of atherogenesis on the clinical manifestations of Parkinson's disease. Material and methods. A total of 84 patients were examined: 32 of them with BP and 52 without clinical signs of BP (comparison group). A method of duplex scanning of the extracranial region of the brachiocephalic arteries was applied using a Toshiba 500 ultrasound scanner using a linear sensor with a frequency of 12 MHz (Toshiba Aplio-2010). Results. As a result of this work, indicators were obtained indicating a lower level of total cholesterol and its fractions, as well as lower values of CMM thickness at the level of the bifurcation of the carotid arteries with a more rare occurrence of atherosclerotic plaques in the lumen of the vessels in the main group, unlike the comparison group. A direct correlation was established between the thickness of the CMI of the carotid arteries at the level of bifurcation on both sides, as well as between the level of LDL cholesterol and total cholesterol. Analysis of lipid metabolism and intima-media complex thickness in patients with varying degrees of severity of Parkinson's disease on the Hen-Yar scale revealed a statistically significant relationship between total cholesterol in the blood of patients with PD and the degree of motor manifestations of the Henn Yar scale. The maximum concentration of total cholesterol is noted in the mixed (acido-rigid-shivering) form of BP. Conclusion. Thus, the results of ultrasound and laboratory studies indicate a decrease in atherogenesis in Parkinson's disease, which suggests a decrease in the risk of atherosclerosis in this cohort of patients. Keywords: parkinson's disease, duplex scanning of the extracranial part of brachiocephalic arteries, atherosclerosis, thickness of intima-media.