The Role of Ultrasound in Modulating Interstitial Fluid Pressure in Solid Tumors for Improved Drug Delivery

Keller, Sara; Averkiou, Michalakis A.

doi:10.1021/acs.bioconjchem.1c00422

Cited by 17 publications

(5 citation statements)

References 83 publications

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“…This force has been shown to improve nanoparticle penetration through the tumor interstitium, especially when focused ultrasound is used (Afadzi et al, 2021; Baghirov et al, 2018; George et al, 2019; Mo et al, 2012). Other ultrasound methodologies (e.g., mechanical and thermal effects from focused ultrasound) have also been used to modulate tumor IFP to improve drug delivery (Keller & Averkiou, 2022). Thus, if the patient is not projected to have effective nanoparticle penetration into the tumor interstitium, tumor‐modulating strategies can be employed.…”

Section: Future Predictions With Ultrasound: a Robust Strategy For Tu...mentioning

confidence: 99%

Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound

Cooley,

Wegierak,

Exner

2024

WIREs Nanomed Nanobiotechnol

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Nanomedicine in oncology has not had the success in clinical impact that was anticipated in the early stages of the field's development. Ideally, nanomedicines selectively accumulate in tumor tissue and reduce systemic side effects compared to traditional chemotherapeutics. However, this has been more successful in preclinical animal models than in humans. The causes of this failure to translate may be related to the intra‐ and inter‐patient heterogeneity of the tumor microenvironment. Predicting whether a patient will respond positively to treatment prior to its initiation, through evaluation of characteristics like nanoparticle extravasation and retention potential in the tumor, may be a way to improve nanomedicine success rate. While there are many potential strategies to accomplish this, prediction and patient stratification via noninvasive medical imaging may be the most efficient and specific strategy. There have been some preclinical and clinical advances in this area using MRI, CT, PET, and other modalities. An alternative approach that has not been studied as extensively is biomedical ultrasound, including techniques such as multiparametric contrast‐enhanced ultrasound (mpCEUS), doppler, elastography, and super‐resolution processing. Ultrasound is safe, inexpensive, noninvasive, and capable of imaging the entire tumor with high temporal and spatial resolution. In this work, we summarize the in vivo imaging tools that have been used to predict nanoparticle distribution and treatment efficacy in oncology. We emphasize ultrasound imaging and the recent developments in the field concerning CEUS. The successful implementation of an imaging strategy for prediction of nanoparticle accumulation in tumors could lead to increased clinical translation of nanomedicines, and subsequently, improved patient outcomes.This article is categorized under: Diagnostic Tools In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery Emerging Technologies

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Section: Future Predictions With Ultrasound: a Robust Strategy For Tu...mentioning

confidence: 99%

Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound

Cooley,

Wegierak,

Exner

2024

WIREs Nanomed Nanobiotechnol

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“…To reduce TIFP in solid tumors, various strategies are being developed including: normalization of the integrity of tumor vessels using antibodies against VEGF in combination with cytotoxic therapy [22,77]. However, strategies aimed at reducing TIFP in tumors, require more detailed studies to improve their effectiveness [78][79][80][81][82]. Our attention was drawn to a method of delivering drugs to head tumors using the Ommaya reservoir [83].…”

Section: High Tumor Interstitial Fluid Pressure (Tifp)mentioning

confidence: 99%

Challenges and Opportunities Associated With Drug Delivery for the Treatment of Solid Tumors

Paresishvili,

Kakabadze

2023

Oncol Rev.

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In this review, we discuss the effectiveness of drug delivery system based on metal nanoparticles, and also, describe the problems associated with their delivery to tumor cells. Throughout recent years, more reports have appeared in the literature that demonstrate promising results for the treatment of various types of cancer using metal-based nanoparticles. Due to their unique physical and chemical properties, metal nanoparticles are effectively being used for the delivery of drug to the tumor cells, for cancer diagnosis and treatment. They can also be synthesized allowing the control of size and shape. However, the effectiveness of the metal nanoparticles for cancer treatment largely depends on their stability, biocompatibility, and ability to selectively affect tumor cells after their systemic or local administration. Another major problem associated with metal nanoparticles is their ability to overcome tumor tissue barriers such as atypical blood vessel structure, dense and rigid extracellular matrix, and high pressure of tumor interstitial fluid. The review also describes the design of tumor drug delivery systems that are based on metal nanoparticles. The mechanism of action of metal nanoparticles on cancer cells is also discussed. Considering the therapeutic safety and toxicity of metal nanoparticles, the prospects for their use for future clinical applications are being currently reviewed.

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“…[63][64][65][66] Compared with other stimulation conditions, ultrasonic triggering is noninvasive, safe, controllable, and economical, and thus deserves attention under novel triggering conditions. Currently, ultrasoundresponsive hydrogels, combining the characteristics of hydrogels and ultrasound, have made many outstanding achievements in biomedical applications, such as drug delivery, [67][68][69][70][71] biomedical imaging 64,72,73 and smart materials, [74][75][76][77] and shown increasingly powerful functions in biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Advances in ultrasound-responsive hydrogels for biomedical applications

2022

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The Role of Ultrasound in Modulating Interstitial Fluid Pressure in Solid Tumors for Improved Drug Delivery

Cited by 17 publications

References 83 publications

Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound

Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound

Challenges and Opportunities Associated With Drug Delivery for the Treatment of Solid Tumors

Advances in ultrasound-responsive hydrogels for biomedical applications

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