The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders

Cutler, Roy G.; Camandola, Simonetta; Malott, Kelli F.; Edelhauser, Maria A.; Mattson, Mark P.

doi:10.2174/1568026615666150610143234

Cited by 36 publications

(23 citation statements)

References 82 publications

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“…Uric acid itself is an antioxidant 19,20. It has also been shown to be neuroprotective against the development of neurodegenerative diseases due to age 21. Although hyperuricemia is correlated with gout, nephropathy, and hypertension, inadequate levels of uric acid have been associated with neurological diseases, such as Parkinson, multiple sclerosis, and dementias.…”

Section: Discussionmentioning

confidence: 99%

Diuretics: A possible keystone in upholding cognitive health

DeLoach

Beall²

2018

Mental Health Clinician

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Introduction:Dementia encompasses diseases of progressive memory loss and neurological alterations, including Alzheimer disease. Hypertension is one risk factor proposed for development of Alzheimer disease. The objective is to evaluate the current literature for use of diuretics in the prevention of dementia.Methods:Literature was not considered if published before January 1, 2000, or after May 31, 2015. PubMed was used to locate sources. Four search terms were used to find data: Alzheimer disease, antihypertensive agents, diuretics, and dementia.Results:Four studies of efficacy of diuretic usage in the prevention against dementia met criteria. Potassium-sparing diuretics displayed risk reduction of Alzheimer disease and maintenance of cognitive function. Risk reduction was demonstrated when used alone (adjusted hazard ratio [aHR] 0.09, 95% confidence interval [CI] 0.01-0.41) as compared to use of other antihypertensives without potassium-sparing diuretics (aHR 0.76, 95% CI 0.49-1.15). Other antihypertensive drug classes did show some benefit, however. Diuretic and angiotensin receptor blocker users had a lower Alzheimer disease risk versus those with no antihypertensive use (hazard ratio 0.40, 95% CI 0.26-0.61) and (hazard ratio 0.37, 95% CI 0.19-0.72), respectively. Additionally, thiazide diuretics were also shown to reduce Alzheimer risk. Thiazide and potassium-sparing combination significantly reduced risk versus non-antihypertensive users (aHR 0.63, 95% CI 0.42-0.94).Discussion:Available research demonstrates an inverse association between diuretic use and the incident rate of dementia. Specifically, this has been found with thiazide and potassium-sparing diuretics when used alone or in combination. This review suggests that patients receiving diuretics for hypertension may receive an added neuroprotective effect.

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Section: Discussionmentioning

confidence: 99%

Diuretics: A possible keystone in upholding cognitive health

DeLoach

Beall²

2018

Mental Health Clinician

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“…However, high uric acid has also been associated with protection against neurodegenerative disorders (Cutler et al . ).…”

Section: Gout and Serum Uric Acidmentioning

confidence: 97%

“…Asymptomatic chronic hyperuricaemia is undesirable as it is a feature of the metabolic syndrome, with evidence of destructive skeletal changes and a role in the development of cardiovascular disease (Desideri et al 2014), non-alcoholic fatty liver disease (Sirota et al 2013), renal dysfunction and insulin resistance (Cirillo et al 2006). However, high uric acid has also been associated with protection against neurodegenerative disorders (Cutler et al 2015).…”

Section: Gout and Serum Uric Acidmentioning

confidence: 99%

Diet and gout – what is the role of purines?

Lockyer

Stanner

2016

Nutrition Bulletin

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Anecdotally, consumption of ‘rich’ foods and drinks, such as cheese and port, has been associated with the development of gout, a painful condition linked to high serum uric acid which normally affects joints in the extremities, such as toes. Risk factors for gout include obesity, genetics and use of certain medications, and men appear to be more at risk. In addition, sufferers report that certain foods trigger gout flares, although there is a paucity of evidence from randomised controlled trials investigating the effect of specific foods on circulating uric acid. Observational studies have consistently identified a positive relationship between gout and some, but not all, foods higher in compounds known as purines, which have been demonstrated to increase serum uric acid in their purified form under controlled conditions. This evidence indicates that foods which should be avoided or consumed infrequently by gout sufferers are offal, seafood and alcohol, especially beer, whereas dairy foods seem to be protective. Current dietary guidelines for the prevention and management of gout share common features and largely reflect international healthy eating guidelines, but differences exist in terms of reference to particular foods or nutrients such as fructose, vitamin C and cherries. More randomised controlled trials are needed to fully ascertain the effects of dietary components on gout risk and to generate more consistent guidelines.

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“…Some studies suggest that uric acid might protect against various neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. 5,6 How to initiate:…”

Section: Treatment Targets For Ultmentioning

confidence: 99%

Initiation of Urate Lowering Therapy (ULT)

Richard¹,

Anita²

2019

SFP

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Background: Mr Tan, 60, a smoker with diabetes mellitus (DM), hypertension and chronic kidney disease (CKD) Stage 3, and recurrent gout flares last five weeks of increasing intensity and duration. He assumes it is due to frequent travel and lack of exercise. He comes today for routine review of his chronic diseases. Current laboratory results are creatinine 106, eGFR 56, uric acid 490, HbA1c 7.3%, random hypocount 8.5 mmol/L. He is on glipizide 5mg bd, Metformin 250mg BD, Amlodipine 5mg OM. He complains of severe gout pain. He had always been reluctant to start definitive treatment which you had previously mentioned. What will you do next?

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The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders

Cited by 36 publications

References 82 publications

Diuretics: A possible keystone in upholding cognitive health

Diuretics: A possible keystone in upholding cognitive health

Diet and gout – what is the role of purines?

Initiation of Urate Lowering Therapy (ULT)

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