The role of urogenital infection in the development of reproductive system disorders in minor children

Abstract

BACKGROUND:Vaginitis and urinary tract infections are common diseases among minors suffering from reproductive system disorders. AIM:To assess the state of vaginal microflora and features of neurohormonal status in adolescent patients with recurrent uro­genital inflammatory diseases. MATERIAL AND METHODS:130teenage girls aged 16–18years were examined, the following groups were identified: first— 34patients with vaginitis and urinary tract infection; the second— 32patients with urinary tract infection, the third— 34patients with vaginitis without urinary tract infection, the fourth— 30teenage girls without vaginitis and urinary tract infection. An assessment of vaginal microbiota and individual parameters of neurohormonal status was carried out. The distribution of variables was checked for normality using the Kolmogorov–Smirnov test; for a normal distribution, the Student t-test; for anon-normal distribution, the Mann–Whitney U test. The significance of differences in relative values was assessed using Fisher and χ2tests. Results were considered statistically significant at p0.05. RESULTS:It was found that in patients of the first group, in comparison with girls from other groups, there were fewer lactobacilli colonies (3.79±0.19genome equivalents/sample; p1–2=0.019, p1–3=0.012, p1–4=0.010), the relative indicator of biota was greater (0.81±0.12; p1–2=0.020; p1–3=0.011; p1–4=0.007). The growth ofCandida spp. colonies 103genome equivalents/sample was detected (82.4%; р1–2=0.021, р1–3=0.011, р1–4=0.002).There was an increase in the concentrations of cortisol (655.7±104.23nmol/l; р1–3=0.021, р1–4=0.024, р1–2=0.032), adrenaline (14.5±3.12nmol/l, р1–3=0.028, р1–4=0.030, р1–2=0.029), decrease in norepinephrine level (1.4±0.11nmol/l, р1–3=0.021, р1–4=0.023, р1–2=0.020), menstrual cycle disorders (85.3%; p1–2=0.024, p1–3=0.019). CONCLUSION:In adolescent girls with recurrent urogenital inflammatory diseases, dysbiotic changes in the vaginal microflora, increased levels of stress hormones, and reproductive system disorders were revealed.