The Role of Vaccines in Combating Antimicrobial Resistance

Jansen, Kathrin U.; Gruber, William C.; Simon, Raphael; Wassil, James; Anderson, Annaliesa S.

doi:10.1007/978-3-030-58259-3_10

Cited by 4 publications

(3 citation statements)

References 300 publications

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“…Thus, the lack of available vaccines for several pathogens is due to the pathogens' complex structure and the obstacles often encountered during the clinical trial experiment. Research on the virulence and pathogenesis of these pathogens and the immunological signature during and after pathogens' invasion will offer the needed support for vaccine formulation and design [19,140,202,210]. Although much has been learned in these areas over the last few years, more remains to be done.…”

Section: Global Issues Future Perspectives and Recommendationsmentioning

confidence: 99%

“…Strategies should be implemented to ensure worldwide access to licensed vaccines, especially in developing countries. There is still room for a faster rollout of vaccines and more efficient logistics to ensure the delivery of the vaccines to all quarters, even in remote areas of developing nations [202]. Consequently, adequate funding is also needed.…”

Section: Global Issues Future Perspectives and Recommendationsmentioning

confidence: 99%

“…Consequently, adequate funding is also needed. The importance of vaccination for AMR reduction should also be incorporated into continuing medical education programs at the grassroots and tertiary level—this could help improve licensed vaccine coverage [7, 19, 202, 203]. Several challenges in maximising licensed vaccines persist.…”

Section: Global Issues Future Perspectives and Recommendationsmentioning

confidence: 99%

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Vaccine development for bacterial pathogens: Advances, challenges and prospects

Elibe

Sharndama

Anyaegbunam

et al. 2023

Tropical Med Int Health

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The advent and use of antimicrobials have played a key role in treating potentially life-threatening infectious diseases, improving health, and saving the lives of millions of people worldwide. However, the emergence of multidrug resistant (MDR) pathogens has been a significant health challenge that has compromised the ability to prevent and treat a wide range of infectious diseases that were once treatable. Vaccines offer potential as a promising alternative to fight against antimicrobial resistance (AMR) infectious diseases. Vaccine technologies include reverse vaccinology, structural biology methods, nucleic acid (DNA and mRNA) vaccines, generalised modules for membrane antigens, bioconjugates/glycoconjugates, nanomaterials and several other emerging technological advances that are offering a potential breakthrough in the development of efficient vaccines against pathogens. This review covers the opportunities and advancements in vaccine discovery and development targeting bacterial pathogens. We reflect on the impact of the already-developed vaccines targeting bacterial pathogens and the potential of those currently under different stages of preclinical and clinical trials. More importantly, we critically and comprehensively analyse the challenges while highlighting the key indices for future vaccine prospects. Finally, the issues and concerns of AMR for low-income countries (sub-Saharan Africa) and the challenges with vaccine integration, discovery and development in this region are critically evaluated. K E Y W O R D Santimicrobial resistant bacteria, bacterial vaccines, emerging vaccine technologies, infectious diseases, lowand middle-income countries, vaccines

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Section: Global Issues Future Perspectives and Recommendationsmentioning

confidence: 99%

Section: Global Issues Future Perspectives and Recommendationsmentioning

confidence: 99%

Section: Global Issues Future Perspectives and Recommendationsmentioning

confidence: 99%

See 1 more Smart Citation

Vaccine development for bacterial pathogens: Advances, challenges and prospects

Elibe

Sharndama

Anyaegbunam

et al. 2023

Tropical Med Int Health

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The impact of human vaccines on bacterial antimicrobial resistance. A review

et al. 2021

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At present, the dramatic rise in antimicrobial resistance (AMR) among important human bacterial pathogens is reaching a state of global crisis threatening a return to the pre-antibiotic era. AMR, already a significant burden on public health and economies, is anticipated to grow even more severe in the coming decades. Several licensed vaccines, targeting both bacterial ( Haemophilus influenzae type b, Streptococcus pneumoniae , Salmonella enterica serovar Typhi) and viral (influenza virus, rotavirus) human pathogens, have already proven their anti-AMR benefits by reducing unwarranted antibiotic consumption and antibiotic-resistant bacterial strains and by promoting herd immunity. A number of new investigational vaccines, with a potential to reduce the spread of multidrug-resistant bacterial pathogens, are also in various stages of clinical development. Nevertheless, vaccines as a tool to combat AMR remain underappreciated and unfortunately underutilized. Global mobilization of public health and industry resources is key to maximizing the use of licensed vaccines, and the development of new prophylactic vaccines could have a profound impact on reducing AMR.

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The role of vaccines in combating antimicrobial resistance (AMR) bacteria

Alghamdi

2021

Saudi Journal of Biological Sciences

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Most pathogens have developed an intrinsic capacity to thrive by developing resistance to antimicrobial compounds utilized in treatment. Antimicrobial resistance arises when microbial agents such as bacteria, viruses, fungi, and parasites alter their behaviour to make current conventional medicines inefficient. Vaccination is one of the most effective strategies to fight antimicrobial resistance. Vaccines, unlike drugs, are less likely to produce resistance since they are precise to their target illnesses. Vaccines against infectious agents such as Streptococcus pneumoniae and Haemophilus influenzae have already been shown to reduce tolerance to antimicrobial medications; however, vaccines against some antimicrobial-resistant pathogens such as Vibrio cholerae, Salmonella typhi, Escherichia coli, nosocomial infections, and pulmonary and diarrheal disease viruses require more research and development. This paper describes vaccine roles in combatting antimicrobial resistance, quantifies the overall advantages of vaccination as an anti-antimicrobial resistance approach, analyzes existing antimicrobial vaccines and those currently under development, and emphasizes some of the obstacles and prospects of vaccine research and development.

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The Role of Vaccines in Combating Antimicrobial Resistance

Cited by 4 publications

References 300 publications

Vaccine development for bacterial pathogens: Advances, challenges and prospects

Vaccine development for bacterial pathogens: Advances, challenges and prospects

The impact of human vaccines on bacterial antimicrobial resistance. A review

The role of vaccines in combating antimicrobial resistance (AMR) bacteria

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