The role of vancomycin-soaking of the graft in anterior cruciate ligament reconstruction

Abstract

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Analysis of reconstitution process, stability, stability of intravenous antibiotics in hospitalised patients in a private hospital

“…Sterility tests were carried out on samples of reconstituted products of intravenous antibiotic preparations (Ghert et al, 2022). In this study, the most widely used antibiotic is the third-generation cephalosporin group, so sterility testing was carried out at the Palembang Health Laboratory Center (BBLK), which showed that the results of ceftriaxone intravenous antibiotic preparation products reconstituted by one of the private hospitals in Palembang with limited facilities and aseptic techniques that are not optimal to produce preparations that are free of microorganisms (sterile) (Rodriguez-Merchan and Ribbans, 2022). This is because the work of ceftriaxone antibiotics is to inhibit and kill germs.…”

Wrap It! Preventive Antimicrobial Treatment Shows No Negative Effects on Tenocytes and Tendons—A Comprehensive Approach

“…The cost-effectiveness is due to the low price of vancomycin and the simplicity of the procedure. Rodriguez-Merchan and Ribbans summarized the knowledge on the in vitro and in vivo studies performed on the vancomycin soaking procedure in their current concept review [ 39 ]. They concluded that, beside the published level III studies, prospective clinical trials are necessary to answer questions such as if this treatment should be used universally in all ACLRs, if incubation time might have an effect and if the vancomycin concentration might be adapted.…”

Lokale Antibiotikatherapie in der Orthopädie und Unfallchirurgie

“…So zeigt die Kombination aus dem hydrophilen Gentamicinsulfat mit dem hydrophoberen Gentamicin-Crobefat Vorteile bez. der Freisetzungskinetik [44,45] Die Anwendung wird durch Editorials, Reviews und Metaanalysen gestützt, die eine deutliche Risikoreduktion hinsichtlich eines Auftretens von Infektionen zeigen [63,64,65,66]. Da keine weitreichenden RCTs zu diesem Thema existieren und die Erkenntnisse vor allem auf Beobachtungsstudien basieren, halten sich Zweifel bez.…”

“…with regards to the occurrence of infections [63,64,65,66]. Since there are no RCTs with comprehensive evidence on this topic and findings are mainly based on observational studies, doubts have been voiced about the possible long-term damage to the implant, the development of resistance, and the risk-benefit ratio (with infection rates in aseptic procedures <1% [64]), which limits their overall use [67].…”