The role of vehicle metamorphosis on triamcinolone acetonide delivery to the skin from microemulsions

Fantini, Adriana; Padula, Cristina; Pescina, Silvia

doi:10.1016/j.ijpharm.2019.04.072

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…In the case of FFS, the formulation's metamorphosis or transformation upon application is the property of special interest, considering the fact that the formulation's characteristics change drastically after solvent displacement, enabling film generation. The importance of formulation metamorphosis was recently rediscovered by both regulatory [14] and research communities [16][17][18][19]. Apart from the obvious impact on dermal bioavailability, the transformation of the drug delivery system during and after application can markedly affect its substantivity and tactile properties [19].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Physico-Mechanical and In Vivo Assessment towards Factual Skin Performance Profile of Topical Polymeric Film-Forming Systems

et al. 2022

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Topical film-forming systems (FFS) change drastically after solvent displacement, therefore indicating their skin metamorphosis/transformation as a property of special regulatory and research interest. This paper deals with the lack of suitable characterization techniques, suggesting a set of methods able to provide a comprehensive notion of FFS skin performance. After screening the physico-chemical, mechanical and sensory properties of FFS and resulting films, an elaborate three-phase in vivo study was performed, covering skin irritation, friction and substantivity. Upon removal of 24-hour occlusion, no significant change in erythema index was observed, while the film-former type (cellulose ether, acrylate and/or vinyl polymer) affected transepidermal water loss (TEWL); hydrophobic methacrylate copolymer-based samples decreased TEWL by 40–50%, suggesting a semi-occlusive effect. Although both the tribological parameters related to the friction coefficient and the friction curve’s plateau provided valuable data, their analysis indicated the importance of the moment the plateau is reached as the onset of the secondary formulation, while the tertiary state is still best described by the completion of the film’s drying time. The final part of the in vivo study proved the high in-use substantivity of all samples but confirmed the optimal 4:1 ratio of hydrophobic cationic and hydrophilic polymers, as indicated during early physico-mechanical screening.

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Section: Introductionmentioning

confidence: 99%

Simultaneous Physico-Mechanical and In Vivo Assessment towards Factual Skin Performance Profile of Topical Polymeric Film-Forming Systems

et al. 2022

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“…Microemulsions (MEs) are isotropic thermodynamically stable lipid-based pharmaceutical systems with a high potential to increase drug skin permeation of drugs through the skin [10,11]. The second contribution developed imiquimod (IMQ)-loaded MEs based on phospholipids and oleic acid to enhance IMQ penetration into the epidermis.…”

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confidence: 99%