The Role of Verb Fluency in the Detection of Early Cognitive Impairment in Alzheimer’s Disease

Alegret, Montserrat; Peretó, Mar; Pérez, Alba; Valero, Sergi; Espinosa, Ana; Ortega, Gemma; Hernández, Isabel; Mauleón, Ana; Rosende-Roca, Maiteé; Vargas, Liliana; Rodríguez-Gómez, Octavio; Abdelnour, Carla; Berthier, Marcelo L.; Bak, Thomas H.; Ruiz, Agustín; Tárraga, Lluís; Boada, Merçé

doi:10.3233/jad-170826

Cited by 41 publications

(38 citation statements)

References 61 publications

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“…For instance, verb fluency (originally referred to as action fluency; see Piatt et al, 1999 for validity;Woods et al, 2005 for normative data) appears sensitive to cognitive deficits stemming from frontal-striatal impairments (Kochhann et al, 2018). Indeed, individuals with mild cognitive impairment (MCI) or subjective cognitive decline (SCD) have been found to show impaired verb fluency performance (Östberg et al, 2005Forlenza et al, 2012;Alegret et al, 2018;Macoir et al, 2019) as have individuals with Alzheimer's disease (AD; Östberg et al, 2007;McDowd et al, 2011;Beber et al, 2015;Dubois et al, 2016;Alegret et al, 2018) and individuals with Parkinson's disease (PD) dementia (Piatt et al, 1999). Verb fluency tasks have also been used to predict dementia severity (e.g., Lai and Lin, 2013) and aid in the differential diagnosis of frontotemporal lobar degeneration (FTLD) vs.…”

Section: Introductionmentioning

confidence: 99%

Neural Correlates of Verb Fluency Performance in Cognitively Healthy Older Adults and Individuals With Dementia: A Pilot fMRI Study

Paek

Murray

Newman

2020

Front. Aging Neurosci.

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Currently there are ∼6 million Americans who are affected by dementia. Verbal fluency tasks have been commonly and frequently utilized to document the disease progression in many forms of dementia. Verb fluency has been found to display substantial potential to detect and monitor the cognitive declines of individuals with dementia who have fronto-striatal involvement. The neural substrates underlying verb fluency task performance, however, have remained unclear so far, especially in individuals with dementia. Therefore, in the current study, brain activation patterns of seven individuals with dementia and nine healthy older adults were investigated using functional MRI. The participants performed in the scanner an overt, subject-paced verb fluency task, representative of fluency tasks used in clinical settings. The brain activation patterns during the verb fluency task were compared between the two groups, and a correlational analysis was conducted to determine the neural correlates of verb fluency performance. The results suggest that compared to healthy older adults, individuals with dementia demonstrated poorer verb fluency performance and showed higher activation in specific neural regions, such as the bilateral frontal lobe. In addition, the correlational analysis revealed that poorer verb fluency performance lead to increased activation in certain cortical and subcortical areas, including left hippocampus and right supramarginal gyrus. The current findings are consistent with previous neurophysiological findings related to semantic (noun) fluency performance in older adults and individuals with dementia and add to the empirical evidence that supports the role of the frontal lobe and hippocampus in verb retrieval and search. Declines in verb fluency performance cannot only be used as a cognitive marker, but also represent neuropathological changes due to the neurodegenerative disease.

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Section: Introductionmentioning

confidence: 99%

Neural Correlates of Verb Fluency Performance in Cognitively Healthy Older Adults and Individuals With Dementia: A Pilot fMRI Study

Paek

Murray

Newman

2020

Front. Aging Neurosci.

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“…However, there is potential for future work examining longitudinal associations. For example, processing speed and executive function have been shown to be more sensitive to cognitive decline among Hispanic/Latino adults compared with Whites [43,44]. The present study provides initial evidence on factors associated with enhanced executive functioning and processing speed, but further investigation is warranted.…”

Section: Discussionmentioning

confidence: 68%

The cross‐sectional association of cognitive stimulation factors and cognitive function among Latino adults in Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Vásquez

Tarraf

Doza

et al. 2019

A&D Transl Res & Clin Interv

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IntroductionHigher cognitive stimulation (CS) is associated with improved cognition. Sources of CS among Hispanics/Latinos are understudied.MethodsIn the Hispanic Community Health Study/Study of Latinos 2008 to 2011 (n = 9438), we used finite mixture models to generate latent CS profiles, and multivariate linear regressions to examine associations with cognition in Hispanic/Latino adults (45–74 years). CS included education, occupation, social network, and acculturation. Cognitive measures included the Six-Item Screener, Brief-Spanish English Verbal Learning Test Sum and Recall, Controlled Oral Word Association Test, Digit Symbol Substitution, and Global Cognition.ResultsTwo CS profiles emerged, and were labeled “typical” and “enhanced.” The enhanced CS profile (22%) had more family connections, bicultural engagements, skilled/professional occupations, education, and higher cognitive scores.DiscussionAn enhanced CS profile emerged from contextual and culturally relevant factors, and was associated with higher cognitive scores across all measures. This provides initial evidence on how factors coalesce to shape cognitive protection in Hispanics/Latinos.

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“…(2) Chinese Version Verbal Learning Test (CVVLT), in which the proposed cutoff point of total score between HC and dementia was 20/21 (Chang et al, 2010); (3) Logic Memory (LM) Test of Wechsler Memory Scale, which has been shown to be a sensitive measure for detecting MCI and AD (Rabin et al, 2009); (4) Boston Naming Test, whose normative data from geriatric performance has been established (Jefferson et al, 2007); (5) Rey-Osterrieth Complex Figure Test, with the proposed cutoff score delayed recall subscale between HC and MCI of 18/19 (Takayama, 2010); (6) Trail Making Test Part A and B, whose psychometric properties have also been established in Chinese version (Wei et al, 2018); (7) Digit Span Forward and Backward Test (Muangpaisan et al, 2010); and (8) Verbal Fluency Test, with the proposed cutoff score between HC and those with cognitive impairments (MCI and mild dementia) of 16/17 (Alegret et al, 2018). Apolipoprotein E ε4 (APOE 4) genotyping was also performed in all subjects.…”

Section: Neuropsychological Testingmentioning

confidence: 99%

Dysfunction of Inferior Parietal Lobule During Sensory Gating in Patients With Amnestic Mild Cognitive Impairment

Cheng

Hsiao²,

Hsieh

et al. 2020

Front. Aging Neurosci.

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Patients with amnestic mild cognitive impairment (aMCI) demonstrate significant cognitive deficits, especially in the memory aspect. The memory deficiency might be attributed to the difficulties in the inhibitory function to suppress redundant stimuli. Sensory gating (SG) refers to the attenuation of neural responses to the second identical stimulus in a paired-click paradigm, in which auditory stimuli are delivered in pairs with inter-stimulus intervals (ISI) of 500 ms and inter-pair intervals of 6-8 s. It is considered as an electrophysiological signal to reflect the brain's automatic response to gate out repetitive sensory inputs. However, there has been no study systematically investigating SG function in aMCI patients. Thus, the present study used magnetoencephalography (MEG) to record neuromagnetic responses to a paired-click paradigm in 23 healthy controls (HC) and 26 aMCI patients. The Stimulus 2/Stimulus 1 (S2/S1) amplitude ratio was used to represent the SG function. Compared to HC, aMCI patients showed M50 SG deficits in the left inferior frontal gyrus (IFG) and right inferior parietal lobule (IPL). M100 SG defects were also observed in the right IPL. Based on the ROIs showing significant between-group SG differences, we found that a more deficient M50 SG function in the right IPL was associated with poorer performance in the immediate recall of Logic Memory (LM), Chinese Version Verbal Learning Test (CVVLT) and Digit Span Backward (DSB) Test. Furthermore, the M50 SG ratios of the right IPL together with the neuropsychological performance of LM and CVVLT demonstrated very good accuracy in the discrimination of aMCI from HC. In conclusion, compared to HC, aMCI patients showed a significant SG deficit in the right IPL, which was correlated with the auditory short-term memory function. We suggest the combination of SG in the right IPL, LM and CVVLT to be sensitive indicators to differentiate aMCI patients from HC.

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The Role of Verb Fluency in the Detection of Early Cognitive Impairment in Alzheimer’s Disease

Cited by 41 publications

References 61 publications

Neural Correlates of Verb Fluency Performance in Cognitively Healthy Older Adults and Individuals With Dementia: A Pilot fMRI Study

Neural Correlates of Verb Fluency Performance in Cognitively Healthy Older Adults and Individuals With Dementia: A Pilot fMRI Study

The cross‐sectional association of cognitive stimulation factors and cognitive function among Latino adults in Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Dysfunction of Inferior Parietal Lobule During Sensory Gating in Patients With Amnestic Mild Cognitive Impairment

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