The role of viruses in idiopathic peripheral facial palsy and cellular immune response

The alteration of SHARPIN expression in the mouse brainstem during herpes simplex virus 1-induced facial palsy

“…According to our data SHARPIN mRNA and protein expression were distinctly increased and peaked at 2 days after facial paralysis, then declined to the normal level during the following 5 days. This trend was consistent with the progression and recovery of facial paralysis in mice [2,4,5]. Using SHARPINdeficient mice embryonic fibroblasts (MEFs), Belgnaoui et al observed an increased and prolonged antiviral response, as well as an impaired TNF-␣-induced NF-B activation.…”

“…This disease takes an acute course without seasonal or gender predilection and half of the patients would develop maximal paralysis within 2 days [2]. A viral etiology, reactivation of HSV-1, has gained popularity over a decade because of the isolation of HSV-1 genome from the facial nerve endoneurial fluid of patients suffering from Bell's palsy [3].…”

Paralysie faciale idiopathique de l’enfant

“…L'étiopathogénie de la PFI n'est pas complètement élucidée. L'hypothèse la plus souvent avancée est celle d'une réactivation de l'herpès simplex virus de type 1 (HSV-1) au niveau du ganglion géniculé [8][9][10]. Des études histologiques ont montré que cette réactivation était à l'origine de phénomènes inflammatoires locaux, de lésions de démyélinisation, et de dégénérescence du nerf facial [11].…”

Bell's Palsy Together With Scarlet Fever In A Child: A Rare Case

“…BP is the most common cause of unilateral facial paralysis and constitutes 60-75% of all cases of FNP [5,6]. Although the incidence of BP in children remains unknown, Peitersen reviewed 2,500 BP cases and reported the incidence for children below 15 years of age as 14% [6]. BP has a better prognosis for the patients below 20 years of age; however, the rate of complete recovery decreases by age [7].…”

“…BP is generally diagnosed via patient's history and the findings of physical examination, without any need for diagnostic imaging and routine laboratory testing [7]. BP is the most common cause of unilateral facial paralysis and constitutes 60-75% of all cases of FNP [5,6]. Although the incidence of BP in children remains unknown, Peitersen reviewed 2,500 BP cases and reported the incidence for children below 15 years of age as 14% [6].…”