The Role of Vitamin B6 in Women’s Health

Lee, Amy S. D.

doi:10.1016/j.cnur.2020.10.002

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…Vitamin B 6 deficiencies have been associated with low socioeconomic status ( Liu et al, 2019 ; Zhu et al, 2020 ), certain medications ( Lussana et al, 2003 ; Allen et al, 2015 ; Porter et al, 2019 ) and a range of diseases including inflammation ( Paul et al, 2013 ), diabetes ( Nix et al, 2015 ; Porter et al, 2019 ), cardiovascular disease ( Dhalla et al, 2013 ; Wei and Ji, 2020 ), and certain cancers ( Gylling et al, 2017 ). Lee (2021) reviews in detail vitamin B 6 deficiency and women’s health issues. In countries where vitamin B 6 status has been studied at the population level, 24% of Americans are at risk or deficient in vitamin B 6 ( Bird et al, 2017 ), rising to one-third in South Korea ( Kim and Cho, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Natural Variation in Vitamin B1 and Vitamin B6 Contents in Rice Germplasm

et al. 2022

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Insufficient dietary intake of micronutrients contributes to the onset of deficiencies termed hidden hunger—a global health problem affecting approximately 2 billion people. Vitamin B1 (thiamine) and vitamin B6 (pyridoxine) are essential micronutrients because of their roles as enzymatic cofactors in all organisms. Metabolic engineering attempts to biofortify rice endosperm—a poor source of several micronutrients leading to deficiencies when consumed monotonously—have led to only minimal improvements in vitamin B1 and B6 contents. To determine if rice germplasm could be exploited for biofortification of rice endosperm, we screened 59 genetically diverse accessions under greenhouse conditions for variation in vitamin B1 and vitamin B6 contents across three tissue types (leaves, unpolished and polished grain). Accessions from low, intermediate and high vitamin categories that had similar vitamin levels in two greenhouse experiments were chosen for in-depth vitamer profiling and selected biosynthesis gene expression analyses. Vitamin B1 and B6 contents in polished seeds varied almost 4-fold. Genes encoding select vitamin B1 and B6 biosynthesis de novo enzymes (THIC for vitamin B1, PDX1.3a–c and PDX2 for vitamin B6) were differentially expressed in leaves across accessions contrasting in their respective vitamin contents. These expression levels did not correlate with leaf and unpolished seed vitamin contents, except for THIC expression in leaves that was positively correlated with total vitamin B1 contents in polished seeds. This study expands our knowledge of diversity in micronutrient traits in rice germplasm and provides insights into the expression of genes for vitamin B1 and B6 biosynthesis in rice.

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Section: Introductionmentioning

confidence: 99%

Natural Variation in Vitamin B1 and Vitamin B6 Contents in Rice Germplasm

et al. 2022

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“…It is involved in numerous biochemical reactions in the body, including the metabolism of amino acids, the synthesis of neurotransmitters, and the regulation of gene expression. There is increasing evidence that VitB 6 is also used as a clinical drug for the treatment of various chronic diseases, [13,14] and may offer protection against these chronic diseases by inhibiting inflammation and oxidative stress. [15][16][17][18][19] The PK/PD of VitB 6 in rats can be influenced by several factors, including the dose and route of administration, the age and sex of the rats, and the presence of other drugs or disease conditions that can affect drug metabolism and clearance.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of vitamin B₆ against doxorubicin‐induced cardiotoxicity by modulating NHE1 expression

Sun,

Wang,

Gui

et al. 2023

J Biochem & Molecular Tox

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Doxorubicin (DOX) has been used to treat various types of cancer, but its application is limited due to its heart toxicity as well as other drawbacks. Chronic inhibition of Na+/H+ exchanger (NHE1) reduces heart failure and reduces the production of reactive oxygen species (ROS); vitamin B6 (VitB6) has been demonstrated to have a crucial role in antioxidant mechanism. So, this study was designed to explore the effect of VitB6 supplement on the DOX‐induced cardiotoxicity and to imply whether NHE1 is involved. Ultrasonic cardiogram analysis revealed that VitB6 supplement could alleviate DOX‐induced cardiotoxicity; hematoxylin and eosin (HE) and Masson's staining further confirmed this effect. Furthermore, VitB6 supplement exhibited significant antioxidative stress and antiapoptosis effect, which was evidenced by decreased serum malondialdehyde (MDA) content and increased serum superoxide dismutase (SOD) content, and decreased Bcl‐2‐associated X protein/B‐cell lymphoma‐2 ratio, respectively. Collectively, VitB6 supplement may exert antioxidative and antiapoptosis effects to improve cardiac function by decreasing NHE1 expression and improve DOX‐induced cardiotoxicity.

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“…Благотворно влияет на сердечно-сосудистую и нервную систему, помогает поддерживать в норме женское здоровье (стабилизирует баланс половых гормонов). [9]  Фолиевая кислота, или витамин B9 (19 мкг). Необходимый микроэлемент для будущих мам -помогает организму подготовиться к беременности, предупреждает развитие патологий плода [10] .…”

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Дынный Сок: 7 Полезных Свойств Для Организма

Шелестун Анна,

Елисеева Татьяна

2022

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Знаменитая конкурентка арбуза и близкая родственница огурца, головокружительно ароматная ложноягода, мякоть которой является не только вкусным, но и чрезвычайно полезным десертом. Конечно, речь идет о дыне, чья медовая мякоть является любимым лакомством многих малышей и взрослых, а также обладает многочисленными целебными свойствами. Сок бахчевых плодов не менее полезен для организма, хотя и не так популярен среди пользователей, как прочие фруктовые фреши. И совершенно зря!

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The Role of Vitamin B6 in Women’s Health

Cited by 3 publications

References 21 publications

Natural Variation in Vitamin B1 and Vitamin B6 Contents in Rice Germplasm

Natural Variation in Vitamin B1 and Vitamin B6 Contents in Rice Germplasm

Protective effect of vitamin B₆ against doxorubicin‐induced cardiotoxicity by modulating NHE1 expression

Дынный Сок: 7 Полезных Свойств Для Организма

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The Role of Vitamin B6 in Women’s Health

Cited by 3 publications

References 21 publications

Natural Variation in Vitamin B1 and Vitamin B6 Contents in Rice Germplasm

Natural Variation in Vitamin B1 and Vitamin B6 Contents in Rice Germplasm

Protective effect of vitamin B6 against doxorubicin‐induced cardiotoxicity by modulating NHE1 expression

Дынный Сок: 7 Полезных Свойств Для Организма

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Protective effect of vitamin B₆ against doxorubicin‐induced cardiotoxicity by modulating NHE1 expression