The role of vitamin D in head and neck cancer

Izreig, Said; Hajek, Michael; Edwards, Heather; Mehra, Saral; Sasaki, Clarence T.; Judson, Benjamin L.; Rahmati, Rahmatullah

doi:10.1002/lio2.469

Cited by 9 publications

(10 citation statements)

References 103 publications

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“…In current study, there were more men than women (5,21), who were reported to have two-fold greater risk of developing HNC than women due to tobacco consumption, alcohol consumption, oropharyngeal cavity hygiene, and human papillomavirus (HR-HPV) infection (3,5,9). Most nasopharyngeal keratinizing squamous cell carcinoma was found in current study, while in other studies, different types of primary tumors and stages of cancer were focused.…”

Section: Discussionmentioning

confidence: 64%

“…(7) Vitamin D could increase T cell activation by increasing the expression of CD4, CD8, and CD69. (8,9) Vitamin D is mainly activated by the binding of 1alpha,25 Dihydroxyvitamin D (1,25(OH)D) (active form) or 25(OH) D (less active form) to the Vitamin D Receptor (VDR), including nuclear receptor members of regulatory genes, which have anti-inflammatory and anti-proliferation activities. (10)(11)(12) Routine examinations of vitamin D levels are often carried out to check the serumal 25(OH)D level, although the active form of vitamin D is 1,25(OH)D. This active form is produced predominantly by the kidneys.…”

Section: Introductionmentioning

confidence: 99%

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Serumal and Salivary 25(OH)D and 1,25(OH)D Levels of Head and Neck Cancer Patients

Sari

Laksmi

et al. 2021

Indones Biomed J

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BACKGROUND: Saliva has been suggested as a substitute of serum for the detection of 25 Dihydroxyvitamin D (25(OH)D) in healthy people. However, investigation of salivary 1,25(OH)D has not been clearly reported. Vitamin plays important roles in inhibiting cancer progression. Current study was conducted to investigate serumal and salivary 25(OH)D) and 1,25(OH)D levels of healthy and head and neck cancer (HNC) subjects.METHODS: Research were conducted at Haji Adam Malik Hospital, Medan, Indonesia. Forty HNC and 40 healthy subjects were recruited and selected based on inclusion and exclusion criteria. Medical records were documented, followed by anthropometric evaluation and serum and saliva collection. Laboratory investigation for 25(OH)D and 1,25(OH) was performed using Enzyme-linked immunosorbent assay (ELISA) methods.RESULTS: Significant serumal (p=0.002) and salivary (p=0.016) 25(OH)D mean level differences of HNC and normal groups were obtained. More serumal or salivary 25(OH)D deficient subjects were found in control group than those in HNC group. Meanwhile, serumal and salivary 1,25(OH)D mean levels of HNC group were not significantly different with the ones of control group. There were significant correlations of serumal-salivary 25(OH)D as well as serumal-salivary 1,25(OH)D levels in normal group.CONCLUSION: Serumal and salivary 25(OH)D and 1,25(OH)D levels of HNC group were relatively normal. Salivary 25(OH)D and 1,25(OH)D could be suggested as substitutes for serumal ones.KEYWORDS: vitamin D, 25(OH)D, 1,25(OH)D, head and neck cancer

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Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Serumal and Salivary 25(OH)D and 1,25(OH)D Levels of Head and Neck Cancer Patients

Sari

Laksmi

et al. 2021

Indones Biomed J

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“…Few studies indicate potential associations between vitamin D and HNC, and supplementation of micronutrients has been proposed to prevent several cancers. (61)(62)(63)(64)(65) HNSCC…”

Section: Micronutrient (Vitamins and Minerals Supplementation)mentioning

confidence: 99%

IAPEN INDIA Consensus Statement on Nutritional Management in Head and Neck Cancers

Timmanpyati¹,

Meenakshi²,

Canday³

et al. 2023

JNUTRES

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Nutritional support is an integral component in the treatment of head and neck cancers (HNC). Studies indicate 90% of HNC patients are at high risk of developing malnutrition. Chemo-radiation and surgery, the three common treatments used to treat HNC are highly susceptible to toxic side effects. Dysphagia is often underestimated in HNC patients. A prolonged impaired swallowing process can lead to severe morbidities like malnutrition, dehydration, aspiration, pneumonia, and even death. These complications have adverse effects on patients' QoL (Quality of Life) and mental health. These adverse reactions further complicate the nutritional status of the patients and the final treatment outcome, increasing morbidity and mortality. The consensus statements try to address nutritional issues and provide practical recommendations for practicing dieticians and clinicians. Keywords: Head and neck cancer guidelines, Nutrition in head and neck cancers, Consensus statements in nutrition in Head and neck cancers, IAPEN head and neck cancer guidelines

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“…Pu et al performed a meta-analysis evaluating Vit D3 exposure and HNC incidence and mortality, and the possible effects of VDR polymorphisms [ 164 ]. They reported an inverse association between the two aforementioned parameters and dietary or supplemental Vit D3 intake, which improved prognosis and quality of life [ 165 ].…”

Section: Vitamin D and Cancermentioning

confidence: 99%

The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies

et al. 2022

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Background: Vitamin D exerts multiple beneficial effects in humans, including neuronal, immune, and bone homeostasis and the regulation of cardiovascular functions. Recent studies correlate vitamin D with cancer cell growth and survival, but meta-analyses on this topic are often not consistent. Methods: A systematic search of the PubMed database and the Clinical Trial Register was performed to identify all potentially relevant English-language scientific papers containing original research articles on the effects of vitamin D on human health. Results: In this review, we analyzed the antioxidant and anti-inflammatory effects of vitamin D against acute and chronic diseases, focusing particularly on cancer, immune-related diseases, cardiomyophaties (including heart failure, cardiac arrhythmias, and atherosclerosis) and infectious diseases. Conclusions: Vitamin D significantly reduces the pro-oxidant systemic and tissue biomarkers involved in the development, progression, and recurrence of chronic cardiometabolic disease and cancer. The overall picture of this review provides the basis for new randomized controlled trials of oral vitamin D supplementation in patients with cancer and infectious, neurodegenerative, and cardiovascular diseases aimed at reducing risk factors for disease recurrence and improving quality of life.

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The role of vitamin D in head and neck cancer

Cited by 9 publications

References 103 publications

Serumal and Salivary 25(OH)D and 1,25(OH)D Levels of Head and Neck Cancer Patients

Serumal and Salivary 25(OH)D and 1,25(OH)D Levels of Head and Neck Cancer Patients

IAPEN INDIA Consensus Statement on Nutritional Management in Head and Neck Cancers

The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies

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