The Role of Vitamin D in Children with Recurrent Tonsillopharyngitis

Yıldız, İsmail; Ünüvar, Emin; Zeybek, Ümit; Toptaş, Bahar; Cacina, Canan; Toprak, Sadık; Kılıç, Ayşe; Aydın, Salih

doi:10.5222/j.child.2012.132

Cited by 9 publications

(25 citation statements)

References 18 publications

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“…6 Furthermore, genetic polymorphism in vitamin D receptors in immune cells that results in modulation of their functions has been indicated. 38 However, both the studies by Yildiz et al 5 and Aydın et al 21 showed insignificant differences between the patients with recurrent tonsillitis and the healthy controls in regards to vitamin D receptor polymorphisms. Nonetheless, it seems that annual frequency of tonsillitis increases in patients with Ff polymorphism in the FokI receptors.…”

Section: Discussionmentioning

confidence: 92%

“…The included studies investigated the vitamin D status (vitamin D deficiency/insufficiency) in both case and control groups. Aydın et al 21 and Nseir et al 23 indicated that the vitamin D deficiency/insufficiency was more prevalent in patients with recurrent tonsillitis as compared with the healthy group, whereas Yildiz et al 5 and Torretta et al 25 suggested that recurrent tonsillitis was not significantly associated with vitamin D deficiency/insufficiency status, as compared to controls. However, the summary ORs revealed that serum vitamin D status had a significant effect on recurrent tonsillitis (OR, 4.37; 95% CI, 2.78-6.88; P < .001; fixed-effect model; Figure 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…Although in some disease polymorphisms, characteristics of the vitamin D receptor gene have been described, the included studies failed to prove an association between the group of recurrent tonsillitis and the healthy control with respect to vitamin D receptor gene polymorphisms. 5,21…”

Section: Resultsmentioning

confidence: 99%

“…Nonetheless, it seems that annual frequency of tonsillitis increases in patients with Ff polymorphism in the FokI receptors. 5…”

Section: Discussionmentioning

confidence: 99%

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The Association Between Vitamin D Deficiency and Recurrent Tonsillitis: A Systematic Review and Meta‐analysis

Mirza

Alharbi

Marzouki

et al. 2020

Otolaryngol.--head neck surg.

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Objectives The role of vitamin D deficiency has been linked with recurrent upper respiratory tract infections, but its impact on the frequency of tonsillitis is not yet fully understood. The objective of this study is to determine the association between vitamin D deficiency and recurrent tonsillitis based on current literature. Data Source A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Data were collected from online medical databases (PubMed, MEDLINE, EMBASE, and Cochrane Collaboration Registry of Controlled Trials). Review Methods All studies addressing the association of vitamin D deficiency and recurrent tonsillitis prior to March 2019. The data were collected in different phases: screening review using search words and controlled vocabularies followed by detailed review of screened articles based on inclusion and exclusion criteria, then a full review that included screening the references of selected articles. Results Fifty-three studies were potentially eligible; of these, 4 publications met the inclusion criteria and were included in the quantitative synthesis. There was a statistically significant reduction of vitamin D levels in patients with recurrent tonsillitis as compared to healthy controls (mean difference, −10.71; 95% CI, −19.12 to −2.31; P = .01). The odds of vitamin D insufficiency were significantly higher in patients with recurrent tonsillitis as compared to the control group (odds ratio, 4.37; 95% CI, 2.78-6.88; P < .001). Conclusion Vitamin D deficiency was present in patients with recurrent tonsillitis and might be associated with an increase in the risk of recurrent tonsillitis. There is a need to explore these findings via clinical trials based on large populations.

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Section: Discussionmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Nonetheless, it seems that annual frequency of tonsillitis increases in patients with Ff polymorphism in the FokI receptors. 5…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Association Between Vitamin D Deficiency and Recurrent Tonsillitis: A Systematic Review and Meta‐analysis

Mirza

Alharbi

Marzouki

et al. 2020

Otolaryngol.--head neck surg.

View full text Add to dashboard Cite

show abstract

“…A study in school-aged children undergoing tonsillectomy due to breathing difficulty and/or recurrent tonsillitis found 78% to have 25(OH)D levels < 30 ng/ mL, and nearly 16% < 20 ng/mL [58]. Another study showed that children with recurrent episodes of tonsillopharyngitis over a 1-year period had serum 25(OH)D levels lower than healthy children [59]. Similarly, another study investigating serum 25(OH)D concentrations among children with recurrent tonsillitis observed again that 25(OH)D levels in candidates for tonsillectomy were significantly lower than those with less than three episodes per year [60].…”

Section: Pharyngotonsillitismentioning

confidence: 99%

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

2019

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Purpose Respiratory tract infections (RTIs) are a major cause of illness worldwide and the most common cause of hospitalization for pneumonia and bronchiolitis. These two diseases are the leading causes of morbidity and mortality among children under 5 years of age. Vitamin D is believed to have immunomodulatory effects on the innate and adaptive immune systems by modulating the expression of antimicrobial peptides, like cathelicidin, in response to both viral and bacterial stimuli. The aim of this review is to summarize the more recently published data with regard to potential associations of 25-hydroxyvitamin D [25(OH)D] with infectious respiratory tract diseases of childhood and the possible health benefits from vitamin D supplementation. Methods The literature search was conducted by using the PubMed, Scopus, and Google Scholar databases, with the following keywords: vitamin D, respiratory tract infection, tuberculosis, influenza, infancy, and childhood. Results Several studies have identified links between inadequate 25(OH)D concentrations and the development of upper or lower respiratory tract infections in infants and young children. Some of them also suggest that intervention with vitamin D supplements could decrease both child morbidity and mortality from such causes. Conclusions Most studies agree in that decreased vitamin D concentrations are prevalent among most infants and children with RTIs. Also, normal to high-serum 25(OH)D appears to have some beneficial influence on the incidence and severity of some, but not all, types of these infections. However, studies with vitamin D supplementation revealed conflicting results as to whether supplementation may be of benefit, and at what doses.

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Are Vitamin D Levels Associated With Risk of Deep Neck Infection?

et al. 2019

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Deep neck infection (DNI) refers to infections in spaces created by superficial and deep cervical fascia around the muscles and organs in the neck. Vitamin D is highly important for an effective immune system. Vitamin D receptors (VDR) have been identified in immune system cells, and particularly in T and B lymphocytes, macrophages, and dendritic cells. Vitamin D deficiency is thought to result in impaired immune response, decreased leukocyte chemotaxis, and an increased disposition to infection. The purpose of this study was to investigate whether vitamin D deficiency is an underlying occult factor in the development of DNI. Sixty-five patients aged 6 to 90, diagnosed with DNI, and 70 healthy age- and sex-compatible cases were included in the study. Serum levels of calcium, phosphorus, parathyroid hormone, and 25-hydroxy vitamin D (25(OH)D) were determined in each case. 25-hydroxy vitamin D levels above 20 ng/mL were regarded as normal, 12 to 20 ng/mL as insufficient, 5 to 12 ng/mL as deficient, and less than 5 ng/mL as severely deficient. Mean serum 25(OH)D levels were 10.4 (6.2) ng/mL in the patient group and 15.5 (6.4) ng/mL in the control group ( P < .01). This difference was statistically significant ( P < .01). Vitamin D was within normal limits in 9.2% (n = 6) of cases in the study group, insufficient in 29.2% (n = 19), deficient in 35.3% (n = 23), and severely deficient in 26.2% (n = 17). The equivalent values in the control group were 21.4% (n = 15), 48.5% (n = 34), 30% (n = 21), and 0% (n = 0). Serum 25(OH)D levels were significantly lower in patients with DNI compared to the healthy cases; 25(OH)D levels may be a factor in the development of DNI.

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The Role of Vitamin D in Children with Recurrent Tonsillopharyngitis

Cited by 9 publications

References 18 publications

The Association Between Vitamin D Deficiency and Recurrent Tonsillitis: A Systematic Review and Meta‐analysis

The Association Between Vitamin D Deficiency and Recurrent Tonsillitis: A Systematic Review and Meta‐analysis

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

Are Vitamin D Levels Associated With Risk of Deep Neck Infection?

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