The role of vitamin D deficiency in the pathogenesis of type 2 diabetes mellitus

Moreira, Tracy S.; Hamadeh, Mazen J.

doi:10.1016/j.eclnm.2010.05.001

Cited by 26 publications

(26 citation statements)

References 72 publications

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“…The demographic characteristics of the study population are shown in Table 1. The median value of duration of diabetes was 7 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12) years. The median levels of 25(OH)D and ESR were 20.6 (14.3-27.2) ng/mL and 17 (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28) mm/h, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…There are various data regarding how vitamin D affects glucose metabolism in patients with diabetes (3,21). In some studies, it has been demonstrated that there are vitamin D receptors in pancreatic beta cells, liver, skeletal muscles, and adipose tissue, and that vitamin D affects insulin synthesis, secretion, and sensitivity through these receptors (3,22,23).…”

Section: Discussionmentioning

confidence: 99%

“…The major points in the pathophysiology of this complex disease are impaired insulin secretion, insulin resistance, and systemic inflammation (2). Studies have shown that vitamin D may have an impact on all of these pathophysiological pathways (3,4). It has been found that vitamin D deficiency is related to increased risk of diabetes, impaired insulin secretion, and an increase in insulin resistance by affecting the glucose metabolism (5,6).…”

Section: Introductionmentioning

confidence: 99%

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e relationship between vitamin D de ciency and erythrocyte sedimentation rate in patients with diabetes

Kaya¹,

Akçay²,

Ertürk³

et al. 2018

Turk J Med Sci

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Background/aim: Vitamin D deficiency in diabetic patients has been shown to be associated with some inflammatory markers. However, its relationship with erythrocyte sedimentation rate (ESR) is still unknown. The aim of this study was to investigate the relationship between vitamin D deficiency and ESR in patients with type 2 diabetes mellitus (T2DM). Materials and methods:This cross-sectional study was conducted with 294 consecutive patients with T2DM. Serum levels of 25-hydroxyvitamin D, glycemic parameters, lipids, ESR, and C-reactive protein were measured. Patients were evaluated according to 25-hydroxyvitamin D levels as having vitamin D deficiency, vitamin D insufficiency, and vitamin D sufficiency.Results: ESR was found to be higher in patients with vitamin D deficiency than in patients who were vitamin D-sufficient (P < 0.001), and ESR was negatively correlated with 25-hydroxyvitamin D level (r = -0.265, P < 0.001). HbA1c and postprandial glucose levels were higher in patients with vitamin D deficiency than vitamin D-sufficient patients (P = 0.005 and P = 0.019, respectively). In receiver operating curve analysis, an ESR value of 14.5 mm/h had 70.1% sensitivity and 50.3% specificity for the prediction of vitamin D deficiency. Conclusion:The present study revealed that ESR is higher in T2DM patients with vitamin D deficiency than patients with sufficient vitamin D. There was an inverse association between ESR and vitamin D levels. Furthermore, vitamin D deficiency was related to poor glycemic control.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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e relationship between vitamin D de ciency and erythrocyte sedimentation rate in patients with diabetes

Kaya¹,

Akçay²,

Ertürk³

et al. 2018

Turk J Med Sci

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“…Hal ini karena tingginya asam dengan PUFA akan membentuk radikal lipid, radikal lemak bebas akan mengakibatkan terjadinya fosforilasi peroksil, dan berbagai senyawa aldehid (20). serin pada reseptor insulin jaringan target, sehingga akan mengurangi aktivitas insulin signaling pathway (GLUT-4) Stress oksidatif akibat tingginya ROS karena adanya yang berfungsi membawa glukosa dari reseptor insulin ke hiperglikemia kronis memicu terjadinya kerusakan DNA dalam sel (5 Semakin tinggi LDL serum maka resiko peningkatan MDA Protein susu menstimulasi pengeluaran dari asam amino semakin besar, karena sebagian besar fosfolipid LDL insulinotropik, IDF-1 (insulin-like-growth-factor 1), lapisan lipidnya berupa PUFA sehingga mudah teroksidasi hormon inkretin, dan GIP (glucose-dependent dan memicu terjadinya peroksidasi lipid (27). Korelasi yang insulinotropic polypeptide) yang dapat meningkatkan positif antara MDA dan LDL juga ditunjukkan pada sensitivitas insulin serta pengeluaran insulin (22).…”

Section: Perubahan Berat Badan Dan Asupan Pakan Tikus Selama Penelitiunclassified

Pengaruh Pemberian Susu Sapi Bubuk terhadap Kadar MDA Hepar pada Tikus Putih (Rattus Novergicus Strain Wistar) Jantan Model Diabetes Melitus Tipe 2

Kurniawan

Nugroho

Adi

2015

JKB

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ABSTRAKKata Kunci: Diabetes melitus tipe 2, ABSTRACT Keywords: C Susu sapi bubuk mengandung kalsium, dan vitamin D yang dapat mencegah peningkatan kadar Malondialdehyde (MDA) pada diabetes melltus tipe 2 melalui mekanisme perbaikan sekresi dan sensitivitas insulin. Susu sapi bubuk mampu menurunkan kondisi stress oksidatif pemicu peningkatan kadar MDA. Tujuan penelitian ini untuk mengetahui pengaruh pemberian susu sapi bubuk terhadap kadar MDA hepar pada tikus wistar model diabetes melitus tipe 2. Penelitian ini adalah penelitian eksperimental post test only control group design menggunakan 30 tikus wistar model diabetes melitus tipe 2. Selama 90 hari, kelompok perlakuan diberikan susu sapi bubuk 0,9g (P1); 1,8g (P2); dan 2,7g (P3) per hari. selanjutnya pada hari ke-91 dilakukan pengukuran kadar MDA dari jaringan hepar dengan spektrofotometer. Hasil menunjukkan terdapat pengaruh pemberian susu sapi bubuk dengan berbagai dosis terhadap kadar MDA jaringan hepar tikus (p=0,003), dengan dosis efektif adalah 1,8g/hari karena dapat mencegah peningkatan kadar MDA mendekati kelompok negatif. Malondialdehyde (MDA), susu sapi bubuk Cow milk powder which contains various components such as calcium and vitamin D can prevent the rise of Malondialdehyde (MDA) in diabetes mellitus

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“…10 However dietary intake accounts only for about 30% of the vitamin D obtained and is not biologically active 11 , therefore the main route for obtaining vitamin D is exposure to ultraviolet B sunlight at wavelengths between 290-315 nm that occur predominantly in the summer months. 12 The biologically active form of vitamin D is 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) that is produced in several steps. The most of vitamin D is obtained by skin in a UVB-induced process in which 7-dehydrocholesterol convert to vitamin D3 followed by two hydroxylations.…”

Section: Iranian Journalmentioning

confidence: 99%

Vitamin D and Multiple Sclerosis

Alappat

Awad

2012

Critical Reviews in Food Science and Nutrition

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The role of vitamin D deficiency in the pathogenesis of type 2 diabetes mellitus

Cited by 26 publications

References 72 publications

e relationship between vitamin D de ciency and erythrocyte sedimentation rate in patients with diabetes

e relationship between vitamin D de ciency and erythrocyte sedimentation rate in patients with diabetes

Pengaruh Pemberian Susu Sapi Bubuk terhadap Kadar MDA Hepar pada Tikus Putih (Rattus Novergicus Strain Wistar) Jantan Model Diabetes Melitus Tipe 2

Vitamin D and Multiple Sclerosis

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