The role of vitamin D in children with recurrent Tonsillopharyngitis

Yıldız, İsmail; Ünüvar, Emin; Zeybek, Ümit; Toptaş, Bahar; Cacina, Canan; Toprak, Sadık; Kılıç, Ayşe; Aydın, Salih

doi:10.1186/1824-7288-38-25

Cited by 29 publications

(38 citation statements)

References 22 publications

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“…An ideal study should encompass vitamin D level measurements at the same seasonal period. Although our laboratory test results are consistent with the studies conducted worldwide, we obtained different results from other studies of Yıldız et al 29 and Aydın et al 7 which were carried out among the Turkish children. This may have been due to our ignoring the seasonal changes, laboratory testing and also not measuring VDR polymorphism.…”

Section: Discussioncontrasting

confidence: 52%

Relationship Between Serum Vitamin D Levels and Childhood Recurrent Tonsillitis

Elbistanlı¹,

Güneş²,

Yeğin³

et al. 2017

Otolaryngol Open J

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Section: Discussioncontrasting

confidence: 52%

Relationship Between Serum Vitamin D Levels and Childhood Recurrent Tonsillitis

Elbistanlı¹,

Güneş²,

Yeğin³

et al. 2017

Otolaryngol Open J

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“…Detection of vitamin D receptors in many tissues of the body has led to the conduction of new studies on the functions, and correlations of vitamin D which plays an important role in the bone-mineral metabolism with various disease states [11]. Vitamin D exerts its effects through activation of vitamin D receptors which regulate transcriptions of target genes responsible for biological effects of its active form 1,25 (OH)2 D [12].…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D levels in children with recurrent tonsillopharyngitis

Collak

Bozaykut

Demirel

et al. 2014

North Clin Istanbul

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OBJECTIVE:In this study, we aimed to compare vitamin D levels of children with recurrent tonsillopharingitis and healthy controls, and investigate the relationship between sociodemographic characteristics and serum vitamin D levels.METHODS:Children with recurrent tonsillopharingitis and healthy controls aged between 2, and 12 years who consulted to the outpatient clinics of Zeynep Kamil Maternity and Children’s Diseases Training and Research Hospital from January to October 2012 were included in this study. Serum 25 (OH) vitamin D levels were studied by tandem mass spectroscopy (tandem ms) method. Risk factors which might be associated with vitamin D levels were questioned. Ethical aproval was obtained from the Ethics Committee of Zeynep Kamil Maternity and Children’s Diseases Training and Research Hospital and informed consent from the parents of the children.RESULTS:A total of 147 children; 74 (50.3%) patients and 73 (49.7%) controls were included in our study. Age, gender and demographic characteristics did not differ significantly between the two groups. Vitamin D levels in patients with recurrent tonsillopharingitis and controls were 19.7±8.7 ng/ml and 23.6±9.2 ng/ml, respectively (p<0.01). Although duration of vitamin D usage was shorter in children with recurrent tonsillopharingitis, this difference was not statistically significant (p>0.05).CONCLUSION:Vitamin D levels in children with ≥7 recurrent episodes of tonsillophargitis within the preceeding year were significantly lower compared to the control group. We believe that serum vitamin D levels should be checked in children with recurrent tonsillopharingitis and deficiencies should be treated.

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“…The average serum 25(OH)D level was 142.7±68.1 nmollL in the children with recurrent pharyngotonsillitis, and 192.3±56.l nmol/L in the control group (p<0.01). Although there was no significant betweengroup difference in vitamin D receptor gene polymorphisms, 4.7% of the children with recurrent pharyngotonsillitis had serum 25(OH)D levels of <50 nmollL as against none in the control group (14).…”

Section: Pharyngotonsillitismentioning

confidence: 99%

“…Finally, another study measured serum 25(OH)D levels and evaluated VitDR gene polymorphisms in 84 children with recurrent pharyngotonsillitis and 71 healthy children aged 2-10 years (14). The average serum 25(OH)D level was 142.7±68.1 nmollL in the children with recurrent pharyngotonsillitis, and 192.3±56.l nmol/L in the control group (p<0.01).…”

Section: Pharyngotonsillitismentioning

confidence: 99%

Role of Vitamin D in Children with Respiratory Tract Infection

Esposito

Baggi

Bianchini

et al. 2013

Int J Immunopathol Pharmacol

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It has recently been shown that vitamin D (VitD) plays an important role in host defences, inflammation and immunity. We reviewed PubMed and selected all of the studies published over the last 15 years concerning vun deficiency and VitD supplementation in children with respiratory tract infections.Our analysis showed that VitD seems to be very important because of its part in the complexity of the immune system. However, there are few pediatric studies and most have various limitations. First of all, the literature mainly refers to studies concerning the prevalence of VitD insufficiency and deficiency in specific pathologies. Secondly, it is extremely difficult to identify a common specific range of normal, insufficient and deficient VitD levels. Thirdly, the available studies of VitD supplementation often combined VitD with the use of other micronutrients, thus obscuring the role of VitD itself. Finally, different doses have been used for VitD supplementation. These observations clearly highlight the fact that further studies are needed to evaluate the impact ofVitD deficiency and insufficiency in terms ofthe epidemiology and outcomes of pediatric respiratory tract infection, and whether VitD supplementation favours a positive outcome.Vitamin D (VitD) is a fat-soluble vitamin that has long been known to play a role in calcium homeostasis and bone metabolism (1). The chemical structure ofthe lateral chains ofthe two natural forms of VitD (D2 derived from plants, and D3 derived from humans and animals) are slightly different, and this causes them to bind differently to their carrier proteins. However, the biological activity of their active metabolic products is very similar. Both can be obtained from diet or from sunlight conversion of skin 7-dehydrocholesterol (1). In order to become active, VitD undergoes two different hydroxylations: the first (in position 25) mainly takes place in the liver and involves the mitochondrial 25-hydroxylase enzyme; the second takes place in the proximal kidney tubule and involves the mitochondrial cytochrome P450 enzyme 25-hydroxyvitamin-D-Ia-hydroxylase (1). Most ofthe final product ofVitD is transported in the blood by albumin and vitamin binding proteins, and thus reaches the numerous target tissues with VitD receptors (VitDRs) found throughout the human body. Once it has performed its function, VitD is inactivated by means of 25 (OH)D-24-hydroxylasis into the inactive 24,25-hydroxyvitamin D (1).VitD is essential for the correct development of mineralised bone (1). In the case of a calciumpoor diet, calcitriols interact with the VitDRs on osteoblasts to induce the expression of the RANK cytokine which, by means of various intracellular messages stimulates maturation of osteoclasts and

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The role of vitamin D in children with recurrent Tonsillopharyngitis

Cited by 29 publications

References 22 publications

Relationship Between Serum Vitamin D Levels and Childhood Recurrent Tonsillitis

Relationship Between Serum Vitamin D Levels and Childhood Recurrent Tonsillitis

Serum vitamin D levels in children with recurrent tonsillopharyngitis

Role of Vitamin D in Children with Respiratory Tract Infection

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