The Role of Vitamin D in Obese Children with Non-Alcoholic Fatty Liver Disease and Associated Metabolic Syndrome

Stepan, Mioara Desdemona; Vintilescu, Ştefăniţa Bianca; Streaţă, Ioana; Podeanu, Mihaela Andreea; Florescu, Dan Nicolae

doi:10.3390/nu15092113

Cited by 9 publications

(5 citation statements)

References 67 publications

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“…Unfortunately, the analysis of the effect of BNC on the bioavailability of vitamin D for rats was beyond the scope of this study. As has been repeatedly shown in clinical observations, deficiency of this vitamin is an important etiological factor in the development of non-alcoholic fatty liver disease [41] and metabolic syndrome [42]; in particular, the latter is reflected in the growth of LDL cholesterol levels in agreement with our observations (see Figure 5c). Deficiency of vitamin B 12 [43] and lipoic acid [44,45] can also disturb lipid metabolism and lead to excess fat accumulation in the liver; this is considered the initial study of steatohepatitis.…”

Section: Discussionsupporting

confidence: 93%

Toxicological Characteristics of Bacterial Nanocellulose in an In Vivo Experiment—Part 1: The Systemic Effects

Shipelin,

Skiba,

Budaeva

et al. 2024

Nanomaterials

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Bacterial nanocellulose (BNC) is being considered as a potential replacement for microcrystalline cellulose as a food additive and a source of dietary fiber due to its unique properties. However, studies on the risks of consuming BNC in food are limited, and it is not yet approved for use in food in the US, EU, and Russia. Aim: This study aims to perform a toxicological and hygienic assessment of the safety of BNC in a subacute 8-week administration in rats. Methods: BNC was administered to male Wistar rats in doses of 0, 1.0, 10.0, and 100 mg/kg body weight for 8 weeks. Various parameters such as anxiety levels, cognitive function, organ masses, blood serum and liver biochemistry, oxidative stress markers, vitamin levels, antioxidant gene expression, and liver and kidney histology were evaluated. Results: Low and medium doses of BNC increased anxiety levels and liver glutathione, while high doses led to elevated LDL cholesterol, creatinine, and uric acid levels. Liver tissue showed signs of degeneration at high doses. BNC did not significantly affect vitamin levels. Conclusion: The adverse effects of BNC are either not dose-dependent or fall within normal physiological ranges. Any effects on rats are likely due to micronutrient deficiencies or impacts on intestinal microbiota.

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Section: Discussionsupporting

confidence: 93%

Toxicological Characteristics of Bacterial Nanocellulose in an In Vivo Experiment—Part 1: The Systemic Effects

Shipelin,

Skiba,

Budaeva

et al. 2024

Nanomaterials

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“…In the realm of treating MAFLD with vitamin D, significant strides have been made. Studies across various regions ( 69 , 70 ) and populations ( 71 , 72 ) have shown that increased vitamin D levels may help prevent MAFLD. Different dosages of vitamin D exhibit varying degrees of improvement in MAFLD ( 33 , 73 ).…”

Section: Vitamins and Mafldmentioning

confidence: 99%

Exploring the interactions between metabolic dysfunction-associated fatty liver disease and micronutrients: from molecular mechanisms to clinical applications

Liu,

Qin,

Chen

et al. 2024

Front. Nutr.

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Metabolic (dysfunction)-associated fatty liver disease (MAFLD) has emerged as a significant global health concern, representing a major cause of liver disease worldwide. This condition spans a spectrum of histopathologic stages, beginning with simple fatty liver (MAFL), characterized by over 5% fat accumulation, and advancing to metabolic (dysfunction)-associated steatohepatitis, potentially leading to hepatocellular carcinoma. Despite extensive research, there remains a substantial gap in effective therapeutic interventions. This condition’s progression is closely tied to micronutrient levels, crucial for biological functions like antioxidant activities and immune efficiency. The levels of these micronutrients exhibit considerable variability among individuals with MAFLD. Moreover, the extent of deficiency in these nutrients can vary significantly throughout the different stages of MAFLD, with disease progression potentially exacerbating these deficiencies. This review focuses on the role of micronutrients, particularly vitamins A, D, E, and minerals like iron, copper, selenium, and zinc, in MAFLD’s pathophysiology. It highlights how alterations in the homeostasis of these micronutrients are intricately linked to the pathophysiological processes of MAFLD. Concurrently, this review endeavors to harness the existing evidence to propose novel therapeutic strategies targeting these vitamins and minerals in MAFLD management and offers new insights into disease mechanisms and treatment opportunities in MAFLD.

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“…Obesity is a cause of many diseases and metabolic dysfunctions, which are part of the so-called metabolic syndrome. The prophylaxis and adjuvant therapies for obesity necessitate the use of appropriate phytochemicals, e.g., vitamins and antioxidants [22,23]. Ellagic acid inhibits the expression of the gene responsible for white adipocytes in rat adipose tissue.…”

Section: Anti-obesity Propertiesmentioning

confidence: 99%

Rubi idaei fructus as a Source of Bioactive Chemical Compounds with an Important Role in Human Health and Comparison of the Antioxidant Potential of Fruits and Juice of Three Repeat-Fruiting Rubus idaeus L. Cultivars

Chwil,

Matraszek-Gawron,

Kostryco

2023

Metabolites

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Rubi idaei fructus is a source of nutritionally important bioactive chemical compounds, mainly antioxidants, which strengthen the immune system and can be used in the prophylaxis and adjuvant therapies of many oxidative stress-induced diseases. There are no literature reports presenting a comprehensive comparative analysis of the antioxidant activity and nutritionally relevant metabolites contained in the fruits of repeat-fruiting raspberry cultivars, which are commonly grown in Europe. The aim of this study was to carry out a comparative analysis of the antioxidant potential (Folin–Ciocalteu, DPPH, FRAP), the content of selected primary and secondary metabolites, and the qualitative and quantitative composition of amino acids and fatty acids in the fruits of R. idaeus cv. ‘Pokusa’, ‘Polana’, and ‘Polka’. The fruits of the analyzed cultivars have a low caloric value (171–219 kcal/100 g); low content of available carbohydrates (6–6.6%) and total carbohydrates (3.4–4.8%); and high levels of dietary fiber (4.7–5.8%), vitamin C (22.8–27 mg/100 g), anthocyanins (25.1–29.6 mg/100 g), and flavonoids (0.5–2.6 mg/100 g). The fruits were found to contain valuable unsaturated fatty acids (35–60%), especially MUFAs with dominant oleic, elaidic, palmitic, and erucic acids and PUFAs (α-linolenic, eicosapentaenoic, and linoleic acids). MUFAs from the ω-9 group accounted for 12–18%, whereas the content of PUFAs from the ω-3 and ω-6 groups was in the range of 15–23 and 6–21%, respectively. Exogenous amino acids, accounting for 56–62%, were dominated by leucine, phenylalanine, and lysine. The following order of the total polyphenolic content was established in the fresh fruit juice from the analyzed cultivars: ‘Pokusa’ < ‘Polana’ < ‘Polka’. The different antioxidant capacity assays used in the study confirmed the high antioxidant potential of the fruits and fresh juice from the three R. idaeus cultivars. This indicates that raspberry fruits can serve as a source of nutrients and can be used as a valuable supplement in a healthy human diet and a raw material in the pharmaceutical and cosmetic industries.

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The Role of Vitamin D in Obese Children with Non-Alcoholic Fatty Liver Disease and Associated Metabolic Syndrome

Cited by 9 publications

References 67 publications

Toxicological Characteristics of Bacterial Nanocellulose in an In Vivo Experiment—Part 1: The Systemic Effects

Toxicological Characteristics of Bacterial Nanocellulose in an In Vivo Experiment—Part 1: The Systemic Effects

Exploring the interactions between metabolic dysfunction-associated fatty liver disease and micronutrients: from molecular mechanisms to clinical applications

Rubi idaei fructus as a Source of Bioactive Chemical Compounds with an Important Role in Human Health and Comparison of the Antioxidant Potential of Fruits and Juice of Three Repeat-Fruiting Rubus idaeus L. Cultivars

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