The Role of Vitamin D in Small Animal Bone Metabolism

Zafalon, Rafael Vessecchi Amorim; Ruberti, Bruna; Rentas, Mariana Fragoso; Amaral, Andressa Rodrigues; Vendramini, Thiago Henrique Annibale; Chacar, Fernanda Chicharo; Kogika, Márcia Mery; Brunetto, Márcio Antônio

doi:10.3390/metabo10120496

Cited by 22 publications

(22 citation statements)

References 175 publications

(269 reference statements)

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“…Metabolomics can be applied to assess the therapeutic effect of drugs or dietary supplements on the recovery of an OP disorder. The effect of dietary Vitamin D on the bone metabolism of cats and dogs has been well reviewed [ 109 ]. The Icariin (IC) potential, a Chinese herbal bioactive molecule, in inducing bone differentiation has been proved previously [ 110 , 111 ].…”

Section: Metabolomics For Development Of Bone Disease Treatment Methodsmentioning

confidence: 99%

Metabolomics in Bone Research

2021

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Identifying the changes in endogenous metabolites in response to intrinsic and extrinsic factors has excellent potential to obtain an understanding of cells, biofluids, tissues, or organisms’ functions and interactions with the environment. The advantages provided by the metabolomics strategy have promoted studies in bone research fields, including an understanding of bone cell behaviors, diagnosis and prognosis of diseases, and the development of treatment methods such as implanted biomaterials. This review article summarizes the metabolism changes during osteogenesis, osteoclastogenesis, and immunoregulation in hard tissue. The second section of this review is dedicated to describing and discussing metabolite changes in the most relevant bone diseases: osteoporosis, bone injuries, rheumatoid arthritis, and osteosarcoma. We consolidated the most recent finding of the metabolites and metabolite pathways affected by various bone disorders. This collection can serve as a basis for future metabolomics-driven bone research studies to select the most relevant metabolites and metabolic pathways. Additionally, we summarize recent metabolic studies on metabolomics for the development of bone disease treatment including biomaterials for bone engineering. With this article, we aim to provide a comprehensive summary of metabolomics in bone research, which can be helpful for interdisciplinary researchers, including material engineers, biologists, and clinicians.

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Section: Metabolomics For Development Of Bone Disease Treatment Methodsmentioning

confidence: 99%

Metabolomics in Bone Research

2021

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“…Der Haupteffekt des Calcitriols ist die Aufrechterhaltung der Kalzium- und Phosphatkonzentration im Blut durch eine gesteigerte Knochenresorption 7 . Calcitriol stimuliert die Reabsorption von Kalzium und Phosphat an der Niere und fördert zudem die intestinale Kalziumaufnahme 5 , 7 .…”

Section: Physiologie Des Kalziumhaushaltsunclassified

Die feline idiopathische Hyperkalzämie – Ein Update zur Diagnostik und Therapie

Stoewe¹,

Wall²,

Mackus³

et al. 2022

kleintier konkret

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“…Vitamin D must be supplemented with the diet since puppies and kittens cannot convert dehydrocholesterol in the skin to a more active form of vitamin D [ 27 ]. In addition to calcium absorption, in the intestine, vitamin D also acts on phosphate absorption, influencing bone growth, mineralization and remodeling [ 28 ]. Calcium-phosphorus ratio is generally stable over time in a bitch’s colostrum and milk (1.5) and rises from colostrum to milk in queens [ 23 ].…”

Section: Composition and Physiological Properties Of Colostrummentioning

confidence: 99%

Nutritional and Functional Properties of Colostrum in Puppies and Kittens

Rossi

Lumbreras

Vagni

et al. 2021

Animals

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The present review aims toward a better understanding of the nutrition of newborn puppies and kittens. The post-natal period is very sensitive in dogs and cats, as in other animal species. During the first two weeks of life, puppies and kittens are at high risk of dehydration, hypothermia, and hypoglycemia, as well as infectious diseases as they start to acquire the physiological functions of the adult. Neonatal hepatic glycogen storage is low, and newborns depend on colostrum intake to survive. Colostrum provides immunoglobulins and other important substances such as lipids and carbohydrates. Immunoglobulins are central to the immunological link that occurs when the mother transfers passive immunity. The mechanism of transfer varies among mammalian species, but in this review, we focused our attention on dogs and cats. Furthermore, there are components of colostrum which, although their presence is not absolutely necessary, play an important role in nutrition. These components have received considerable interest because of their presumed safety and potential nutritional and therapeutic effects both in humans and animals; however, unfortunately, there are few recent studies in companion animals. Here, we have gathered the published articles that describe studies involving different species of animals, emphasizing companion animals. In particular, the purpose of this narrative of the nutritional and functional proprieties of queens’ and bitches’ colostrum.

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The Role of Vitamin D in Small Animal Bone Metabolism

Cited by 22 publications

References 175 publications

Metabolomics in Bone Research

Metabolomics in Bone Research

Die feline idiopathische Hyperkalzämie – Ein Update zur Diagnostik und Therapie

Nutritional and Functional Properties of Colostrum in Puppies and Kittens

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