The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease

Nobile, Stefano; Tenace, Michela A.; Pappa, Helen

doi:10.3390/gidisord1010018

Cited by 6 publications

(4 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, vitamin D, beyond its classic role in calcium and bone homeostasis, plays a dynamic role in regulation of the immune system [17]. In the pathogenesis of immune-mediated diseases such as IBD, vitamin D is considered a paramount element [18,19]. Incidence of hypovitaminosis D is higher in patients with IBD (from 16% to 95%) than in the healthy population [20], and it is higher in patients with Crohn’s Disease than in those with Ulcerative Colitis [21].…”

Section: Introductionmentioning

confidence: 99%

The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD

et al. 2019

View full text Add to dashboard Cite

Hypovitaminosis D is frequently present in inflammatory bowel disease (IBD) with a higher incidence in Crohn’s disease (CD) than in Ulcerative Colitis (UC). Given the involvement of the alimentary tract, many factors can contribute to hypovitaminosis D. The aim of the study was to investigate the association of disease activity, body mass index (BMI) and phase angle with vitamin D deficiency in patients with IBD. A cross-sectional study was conducted on a cohort of 206 IBD patients (October 2016–September 2018). Of these patients, 32.6% were affected by hypovitaminosis D (CD: 38.6%; UC: 25.6%; p < 0.01). Negative and significant associations (p < 0.01) were found between BMI and vitamin D serum levels both in CD and UC patients. BMI represented a determinant of hypovitaminosis D (Odds Ratio (OR) = 1.12, p < 0.01) only in UC patients; phase angle was associated to hypovitaminosis D in both groups (CD: OR = 0.64, p < 0.05; UC: OR = 0.49, p < 0.01). Results of the present study confirm a higher incidence of hypovitaminosis D in patients with CD than in those with UC, and show that nutritional status plays a crucial role in the incidence of vitamin D deficiency in patients with IBD.

show abstract

Section: Introductionmentioning

confidence: 99%

The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Previous studies reported that the disease activity index score was significantly lower in the mice groups receiving low and high doses of vitamin D3 compared to the control group, and significantly lower in mice given high doses of vitamin D3 compared to the control group. 22 The IL-17 and IL-17R levels were significantly lower in mice given high doses of vitamin D3 compared to the low dose group. 23 This findings suggest that vitamin D may increase the chemotaxis and differentiation of Th1 cells by inhibiting IL-17/IL-17R signaling, thereby increasing immune function, and reducing IBD disease severity.…”

Section: Discussionmentioning

confidence: 89%

Role of vitamin D3 on IL-17 expression in colon and improvement of colonic mucosa in an inflammatory bowel disease mice model

Paramitha

Wibowo²

2022

View full text Add to dashboard Cite

Background Inflammatory bowel disease (IBD) is an inflammation due to a Th1/Th2 regulatory imbalance and a Th17/Treg transformation imbalance which then releases inflammatory mediators, such as interleukin-17. The administration of vitamin D has the potential to prevent the inflammation in IBD. Objective To evaluate a possible role of vitamin D3 in reducing IL-17 expression and colonic mucosal repair in an IBD mice model. Methods The study used male BALB/c mice, 8-10 weeks old, weighing 20-25 grams, divided randomly into five groups with 8 mices in each group. The experimental mice were given 5% dextran sulfate sodium (DSS) on days 1-7 to induce colitis, and then were given vitamin D3 on days 8-14. Group 1 was the control group; Group 2 was given 5% DSS; Group 3 was given 5% DSS and vitamin D3 0.2 mcg/25 g body weight; Group 4 was given 5% DSS and vitamin D3 0.4 mcg/25 g body weight; and Group 5 was given 5% DSS and vitamin D3 0.6 mcg/25 g body weight. On day 15, the mice underwent euthanasia and colonic retrieval. Parameters assessed were IL-17 expression (immunohistochemical, with monoclonal antibody against IL-17) and colonic histology improvement, using the mouse colitis histology index (MCHI) score. Results The IL-17 expression measured by immunohistochemistry increased significantly in only 5% DSS group. There was a significant decrease in MCHI scores in the groups given vitamin D3, where the greater the dose of vitamin D3 given, the lower the MCHI score. Interleukin-17 expression had positive strong correlation with MCHI (r=0.985; P=0.002) Conclusion The improvement of colonic mucosal damage based on MCHI score was significant in groups given vitamin D3. There is a significant correlation between IL-17 reduction and colonic mucosal repair in IBD mice.

show abstract

“…Moreover, single-nucleotide polymorphisms in the human VDR gene were reported to be associated with an elevated susceptibility to IBD [ 77 , 78 ]. The four most frequently studied are common VDR polymorphisms recognized by restriction enzymes: rs7975232 (c.1025-49 G > T, ApaI) and rs1544410 (c.1024 + 283 G > A, BsmI) at the 3′ flanking end of intron 8, rs731236 (c.1056 T > C, p.Ile352=, TaqI) at the 3′ flanking end of exon 9, and rs2228570 (c.2T > C, p.Met1Thr, FokI) at the 5′ end of exon 2 [ 79 , 80 ].…”

Section: Genetic Determinants Of Vitamin D Activity In Ibdsmentioning

confidence: 99%

Pleiotropic Effects of Vitamin D in Patients with Inflammatory Bowel Diseases

Szymczak-Tomczak

Ratajczak

Kaczmarek-Ryś

et al. 2022

JCM

View full text Add to dashboard Cite

The multifaceted activity of vitamin D in patients with inflammatory bowel disease (IBD) presents a challenge for further research in this area. Vitamin D is involved in the regulation of bone mineral metabolism, it participates in the regulation of the immune system, and it is an underlying factor in the pathogenesis of IBD. Additionally, vitamin D affects Th1 and Th2 lymphocytes, influencing the release of cytokines and inhibiting tumor necrosis factor (TNF) expression and the wnt/β-catenin pathway. As far as IBDs are concerned, they are associated with microbiota dysbiosis, abnormal inflammatory response, and micronutrient deficiency, including vitamin D hypovitaminosis. In turn, the biological activity of active vitamin D is regulated by the vitamin D receptor (VDR) which is associated with several processes related to IBD. Therefore, in terms of research on vitamin D supplementation in IBD patients, it is essential to understand the metabolic pathways and genetic determinants of vitamin D, as well as to identify the environmental factors they are subject to, not only in view of osteoporosis prevention and therapy, but primarily concerning modulating the course and supplementation of IBD pharmacotherapy.

show abstract

The Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Disease

Cited by 6 publications

References 59 publications

The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD

The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD

Role of vitamin D3 on IL-17 expression in colon and improvement of colonic mucosa in an inflammatory bowel disease mice model

Pleiotropic Effects of Vitamin D in Patients with Inflammatory Bowel Diseases

Contact Info

Product

Resources

About